Gene Combination List
This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.
GET /api/genecombinations/?format=api
{ "data": [ { "type": "GeneCombination", "id": "1", "attributes": { "gene_relationship": [ "Involved in the same disease", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:45.218167" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI001" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "ALAD" }, { "type": "Gene", "id": "CPO" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/1/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/1/?format=api" } }, { "type": "GeneCombination", "id": "2", "attributes": { "gene_relationship": [ "Involved in the same disease", "Same pathway" ], "protein_interactions": [], "common_pathways": [ "MicroRNAs in cancer", "Signal Transduction" ], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:00:45.251046" }, "relationships": { "combination_set": { "meta": { "count": 2 }, "data": [ { "type": "Combination", "id": "OLI002" }, { "type": "Combination", "id": "OLI003" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/2/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/2/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "BMPR2" }, { "type": "Gene", "id": "NOTCH3" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/2/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/2/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/2/?format=api" } }, { "type": "GeneCombination", "id": "3", "attributes": { "gene_relationship": [ "Involved in the same disease", "Same pathway" ], "protein_interactions": [], "common_pathways": [ "Disease" ], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:00:45.328638" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI004" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/3/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/3/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "ABCC8" }, { "type": "Gene", "id": "NOTCH3" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/3/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/3/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/3/?format=api" } }, { "type": "GeneCombination", "id": "4", "attributes": { "gene_relationship": [ "Involved in the same disease" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 0, "lastmodified": "2021-10-18T11:00:45.364003" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI005" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/4/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/4/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "ABCC8" }, { "type": "Gene", "id": "SARS2" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/4/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/4/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/4/?format=api" } }, { "type": "GeneCombination", "id": "5", "attributes": { "gene_relationship": [ "Involved in the same disease" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 0, "lastmodified": "2021-10-18T11:00:45.401203" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI006" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/5/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/5/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "SMAD1" }, { "type": "Gene", "id": "TBX4" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/5/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/5/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/5/?format=api" } }, { "type": "GeneCombination", "id": "6", "attributes": { "gene_relationship": [ "Affecting the same tissue", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 3, "lastmodified": "2021-10-18T11:00:45.442527" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI007" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/6/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/6/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "ADD3" }, { "type": "Gene", "id": "KAT2B" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/6/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/6/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/6/?format=api" } }, { "type": "GeneCombination", "id": "7", "attributes": { "gene_relationship": [ "Involved in the same disease", "Affecting the same tissue", "Relevant pathways for phenotype", "Same pathway", "Similar function" ], "protein_interactions": [], "common_pathways": [ "Sodium-coupled phosphate cotransporters", "Transport of inorganic cations/anions and amino acids/oligopeptides", "Disease", "SLC-mediated transmembrane transport", "Transport of small molecules", "secretion and action", "SLC transporter disorders", "Type II Na+/Pi cotransporters", "Parathyroid hormone synthesis", "Disorders of transmembrane transporters" ], "genecomb_metascore": 3, "lastmodified": "2021-10-18T11:00:45.477145" }, "relationships": { "combination_set": { "meta": { "count": 3 }, "data": [ { "type": "Combination", "id": "OLI008" }, { "type": "Combination", "id": "OLI1790" }, { "type": "Combination", "id": "OLI1791" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/7/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/7/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "SLC34A1" }, { "type": "Gene", "id": "SLC34A3" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/7/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/7/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/7/?format=api" } }, { "type": "GeneCombination", "id": "8", "attributes": { "gene_relationship": [ "Involved in the same disease", "Directly interacting", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 3, "lastmodified": "2021-10-18T11:00:45.516609" }, "relationships": { "combination_set": { "meta": { "count": 4 }, "data": [ { "type": "Combination", "id": "OLI009" }, { "type": "Combination", "id": "OLI010" }, { "type": "Combination", "id": "OLI011" }, { "type": "Combination", "id": "OLI012" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/8/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/8/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "CYP1B1" }, { "type": "Gene", "id": "TEK" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/8/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/8/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/8/?format=api" } }, { "type": "GeneCombination", "id": "9", "attributes": { "gene_relationship": [ "Involved in the same disease", "Affecting the same tissue" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:00:45.632482" }, "relationships": { "combination_set": { "meta": { "count": 2 }, "data": [ { "type": "Combination", "id": "OLI013" }, { "type": "Combination", "id": "OLI060" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/9/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/9/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "GJB2" }, { "type": "Gene", "id": "TMPRSS3" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/9/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/9/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/9/?format=api" } }, { "type": "GeneCombination", "id": "10", "attributes": { "gene_relationship": [ "Involved in the same disease", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:00:45.660586" }, "relationships": { "combination_set": { "meta": { "count": 2 }, "data": [ { "type": "Combination", "id": "OLI014" }, { "type": "Combination", "id": "OLI1164" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/10/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/10/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "PROKR2" }, { "type": "Gene", "id": "WDR11" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/10/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/10/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/10/?format=api" } }, { "type": "GeneCombination", "id": "11", "attributes": { "gene_relationship": [ "Directly interacting", "Involved in the same disease", "Relevant pathways for phenotype", "Same pathway", "Similar function" ], "protein_interactions": [ "(ATP6V0A4, ATP6V1B1)" ], "common_pathways": [ "Signaling by Receptor Tyrosine Kinases", "Synaptic vesicle cycle", "Phagosome", "Metabolic pathways", "Transport of small molecules", "Oxidative phosphorylation", "Immune System", "Ion channel transport", "Transferrin endocytosis and recycling", "Rheumatoid arthritis", "Iron uptake and transport", "Innate Immune System", "Collecting duct acid secretion", "ROS and RNS production in phagocytes", "Vibrio cholerae infection", "Epithelial cell signaling in Helicobacter pylori infection", "Insulin receptor recycling", "Human papillomavirus infection", "Signaling by Insulin receptor", "Signal Transduction" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:45.688645" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI015" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/11/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/11/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "ATP6V0A4" }, { "type": "Gene", "id": "ATP6V1B1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/11/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/11/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/11/?format=api" } }, { "type": "GeneCombination", "id": "12", "attributes": { "gene_relationship": [ "Involved in the same disease", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:00:45.725710" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI016" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/12/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/12/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "ANO5" }, { "type": "Gene", "id": "COL6A2" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/12/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/12/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/12/?format=api" } }, { "type": "GeneCombination", "id": "13", "attributes": { "gene_relationship": [ "Involved in the same disease", "Affecting the same tissue" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:00:45.754415" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI017" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/13/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/13/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "ANO5" }, { "type": "Gene", "id": "SGCA" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/13/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/13/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/13/?format=api" } }, { "type": "GeneCombination", "id": "14", "attributes": { "gene_relationship": [ "Involved in the same disease", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:00:45.783619" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI018" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/14/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/14/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "RNF216" }, { "type": "Gene", "id": "SRA1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/14/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/14/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/14/?format=api" } }, { "type": "GeneCombination", "id": "16", "attributes": { "gene_relationship": [ "Involved in the same disease", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:00:45.841380" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI020" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/16/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/16/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "CHD7" }, { "type": "Gene", "id": "PROP1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/16/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/16/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/16/?format=api" } }, { "type": "GeneCombination", "id": "17", "attributes": { "gene_relationship": [ "Affecting the same tissue", "Directly interacting", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [ "(GDNF, RET)" ], "common_pathways": [ "MAPK family signaling cascades", "Nervous system development", "Calcium signaling pathway", "RET signaling", "Axon guidance", "RAF/MAP kinase cascade", "Developmental Biology", "Signal Transduction" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:45.869803" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI021" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/17/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/17/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "GDNF" }, { "type": "Gene", "id": "RET" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/17/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/17/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/17/?format=api" } }, { "type": "GeneCombination", "id": "18", "attributes": { "gene_relationship": [ "Involved in the same disease", "Affecting the same tissue", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [], "common_pathways": [], "genecomb_metascore": 1, "lastmodified": "2021-10-18T11:00:45.899516" }, "relationships": { "combination_set": { "meta": { "count": 2 }, "data": [ { "type": "Combination", "id": "OLI022" }, { "type": "Combination", "id": "OLI1732" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/18/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/18/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "SQSTM1" }, { "type": "Gene", "id": "TIA1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/18/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/18/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/18/?format=api" } }, { "type": "GeneCombination", "id": "19", "attributes": { "gene_relationship": [ "Involved in the same disease", "Affecting the same tissue", "Colocalization", "Same pathway", "Similar function" ], "protein_interactions": [], "common_pathways": [ "Neurexins and neuroligins", "Protein-protein interactions at synapses", "Neuronal System", "Cell adhesion molecules" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:45.928322" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI023" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/19/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/19/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "NRXN1" }, { "type": "Gene", "id": "NRXN2" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/19/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/19/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/19/?format=api" } }, { "type": "GeneCombination", "id": "20", "attributes": { "gene_relationship": [ "Involved in the same disease", "Directly interacting", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [ "(MSH6, MUTYH)" ], "common_pathways": [], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:00:45.956431" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI024" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/20/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/20/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "MSH6" }, { "type": "Gene", "id": "MUTYH" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/20/relationships/genes?format=api", "related": 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