Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1098/genes/?format=api
{ "data": [ { "type": "Gene", "id": "FOXP1", "attributes": { "go_molecular_function": [ "['core promoter sequence-specific DNA binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'DNA-binding transcription repressor activity, RNA polymerase II-specific', 'protein self-association', 'DNA-binding transcription factor activity, RNA polymerase II-specific', 'sequence-specific double-stranded DNA binding', 'protein binding', 'metal ion binding', 'identical protein binding', 'androgen receptor binding']" ], "pathway_id": [ "kegg_path:hsa05206", "kegg_path:hsa05206" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "A0A0B4J2F3", "ensembl_id": "None", "entrez_id": "ENSG00000114861", "chromosome_number": "3", "lastmodified": "2023-05-16T12:02:32.502054" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "3208" }, { "type": "SmallVariant", "id": "2639" }, { "type": "SmallVariant", "id": "3266" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FOXP1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FOXP1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "879" }, { "type": "GeneCombination", "id": "1072" }, { "type": "GeneCombination", "id": "1098" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FOXP1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FOXP1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FOXP1/?format=api" } }, { "type": "Gene", "id": "GLI2", "attributes": { "go_molecular_function": [ "['zinc ion binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'sequence-specific double-stranded DNA binding', 'sequence-specific DNA binding', 'protein binding', 'DNA-binding transcription factor activity', 'promoter-specific chromatin binding', 'DNA-binding transcription factor activity, RNA polymerase II-specific']" ], "pathway_id": [ "kegg_path:hsa04340", "kegg_path:hsa04390", "kegg_path:hsa05200", "kegg_path:hsa05217", "R-HSA-162582", "R-HSA-212436", "R-HSA-5358351", "R-HSA-5610783", "R-HSA-5610787", "R-HSA-5632684", "R-HSA-5635851", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878166", "R-HSA-8941284", "R-HSA-8941326", "kegg_path:hsa04340", "kegg_path:hsa04390", "kegg_path:hsa05200", "kegg_path:hsa05217" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P10070", "ensembl_id": "None", "entrez_id": "ENSG00000074047", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.515380" }, "relationships": { "variant_set": { "meta": { "count": 14 }, "data": [ { "type": "SmallVariant", "id": "725" }, { "type": "SmallVariant", "id": "735" }, { "type": "SmallVariant", "id": "1217" }, { "type": "SmallVariant", "id": "1281" }, { "type": "SmallVariant", "id": "2493" }, { "type": "SmallVariant", "id": "2512" }, { "type": "SmallVariant", "id": "2514" }, { "type": "SmallVariant", "id": "3164" }, { "type": "SmallVariant", "id": "3199" }, { "type": "SmallVariant", "id": "3201" }, { "type": "SmallVariant", "id": "3213" }, { "type": "SmallVariant", "id": "3229" }, { "type": "SmallVariant", "id": "3265" }, { "type": "SmallVariant", "id": "3487" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GLI2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GLI2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 16 }, "data": [ { "type": "GeneCombination", "id": "232" }, { "type": "GeneCombination", "id": "235" }, { "type": "GeneCombination", "id": "407" }, { "type": "GeneCombination", "id": "387" }, { "type": "GeneCombination", "id": "844" }, { "type": "GeneCombination", "id": "852" }, { "type": "GeneCombination", "id": "853" }, { "type": "GeneCombination", "id": "1056" }, { "type": "GeneCombination", "id": "1068" }, { "type": "GeneCombination", "id": "1069" }, { "type": "GeneCombination", "id": "1081" }, { "type": "GeneCombination", "id": "1098" }, { "type": "GeneCombination", "id": "1102" }, { "type": "GeneCombination", "id": "1173" }, { "type": "GeneCombination", "id": "1074" }, { "type": "GeneCombination", "id": "1253" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GLI2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GLI2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GLI2/?format=api" } }, { "type": "Gene", "id": "HS6ST1", "attributes": { "go_molecular_function": [ "['heparan sulfate 6-O-sulfotransferase activity', 'protein binding', 'sulfotransferase activity']" ], "pathway_id": [ "kegg_path:hsa00534", "R-HSA-1430728", "R-HSA-1630316", "R-HSA-1638091", "R-HSA-2022928", "R-HSA-71387" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "O60243", "ensembl_id": "None", "entrez_id": "ENSG00000136720", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.274137" }, "relationships": { "variant_set": { "meta": { "count": 10 }, "data": [ { "type": "SmallVariant", "id": "783" }, { "type": "SmallVariant", "id": "807" }, { "type": "SmallVariant", "id": "853" }, { "type": "SmallVariant", "id": "1415" }, { "type": "SmallVariant", "id": "2498" }, { "type": "SmallVariant", "id": "2670" }, { "type": "SmallVariant", "id": "2779" }, { "type": "SmallVariant", "id": "2839" }, { "type": "SmallVariant", "id": "2969" }, { "type": "SmallVariant", "id": "3267" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HS6ST1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HS6ST1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 10 }, "data": [ { "type": "GeneCombination", "id": "245" }, { "type": "GeneCombination", "id": "252" }, { "type": "GeneCombination", "id": "444" }, { "type": "GeneCombination", "id": "847" }, { "type": "GeneCombination", "id": "889" }, { "type": "GeneCombination", "id": "929" }, { "type": "GeneCombination", "id": "944" }, { "type": "GeneCombination", "id": "263" }, { "type": "GeneCombination", "id": "989" }, { "type": "GeneCombination", "id": "1098" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HS6ST1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HS6ST1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/HS6ST1/?format=api" } }, { "type": "Gene", "id": "HSD17B6", "attributes": { "go_molecular_function": [ "['17-beta-hydroxysteroid dehydrogenase (NADP+) activity', 'androstan-3-alpha,17-beta-diol dehydrogenase activity', '5alpha-androstane-3beta,17beta-diol dehydrogenase activity', 'testosterone 17-beta-dehydrogenase (NADP+) activity', 'testosterone dehydrogenase (NAD+) activity', '17-beta-hydroxysteroid dehydrogenase (NAD+) activity', 'NAD-retinol dehydrogenase activity', 'electron transfer activity', 'oxidoreductase activity', 'catalytic activity', 'androsterone dehydrogenase activity']" ], "pathway_id": [ "kegg_path:hsa00140", "kegg_path:hsa00830", "kegg_path:hsa01100", "kegg_path:hsa01240", "kegg_path:hsa00140", "kegg_path:hsa00830", "kegg_path:hsa01100", "kegg_path:hsa01240", "R-HSA-162582", "R-HSA-2187338", "R-HSA-2453902", "R-HSA-372790", "R-HSA-388396", "R-HSA-418594" ], "essential_gene": null, "status": "CU", "uniprot_acc": "O14756", "ensembl_id": "None", "entrez_id": "ENSG00000025423", "chromosome_number": "12", "lastmodified": "2023-05-16T12:02:33.587797" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "3207" }, { "type": "SmallVariant", "id": "3227" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HSD17B6/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HSD17B6/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "1072" }, { "type": "GeneCombination", "id": "1079" }, { "type": "GeneCombination", "id": "1098" }, { "type": "GeneCombination", "id": "1101" }, { "type": "GeneCombination", "id": "1116" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HSD17B6/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HSD17B6/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/HSD17B6/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }