Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1107/genes/?format=api
{ "data": [ { "type": "Gene", "id": "AKR1C4", "attributes": { "go_molecular_function": [ "['electron transfer activity', 'ketosteroid monooxygenase activity', 'chlordecone reductase activity', 'testosterone 17-beta-dehydrogenase (NADP+) activity', 'androsterone dehydrogenase activity', '17-beta-hydroxysteroid dehydrogenase (NADP+) activity', 'steroid dehydrogenase activity', 'D-threo-aldose 1-dehydrogenase activity', 'oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor', '17-beta-hydroxysteroid dehydrogenase (NAD+) activity', 'dihydrotestosterone 17-beta-dehydrogenase activity', 'bile acid transmembrane transporter activity', '5alpha-androstane-3beta,17beta-diol dehydrogenase activity', 'bile acid binding', 'alditol:NADP+ 1-oxidoreductase activity', 'retinal dehydrogenase activity', 'testosterone dehydrogenase (NAD+) activity', 'aldo-keto reductase (NADP) activity', 'androstan-3-alpha,17-beta-diol dehydrogenase activity']" ], "pathway_id": [ "kegg_path:hsa00120", "kegg_path:hsa00140", "kegg_path:hsa01100", "R-HSA-1430728", "R-HSA-162582", "R-HSA-192105", "R-HSA-193368", "R-HSA-193775", "R-HSA-193807", "R-HSA-194068", "R-HSA-196854", "R-HSA-2187338", "R-HSA-372790", "R-HSA-388396", "R-HSA-418594", "R-HSA-556833", "R-HSA-6806667", "R-HSA-8957322", "R-HSA-975634", "kegg_path:hsa00120", "kegg_path:hsa00140", "kegg_path:hsa01100", "R-HSA-1430728", "R-HSA-162582", "R-HSA-192105", "R-HSA-193368", "R-HSA-193775", "R-HSA-193807", "R-HSA-194068", "R-HSA-196854", "R-HSA-2187338", "R-HSA-372790", "R-HSA-388396", "R-HSA-418594", "R-HSA-556833", "R-HSA-6806667", "R-HSA-8957322", "R-HSA-975634" ], "essential_gene": null, "status": "CU", "uniprot_acc": "P17516", "ensembl_id": "None", "entrez_id": "ENSG00000198610", "chromosome_number": "10", "lastmodified": "2023-05-16T12:02:33.621158" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "3228" }, { "type": "SmallVariant", "id": "3244" }, { "type": "SmallVariant", "id": "3291" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AKR1C4/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AKR1C4/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "1079" }, { "type": "GeneCombination", "id": "1087" }, { "type": "GeneCombination", "id": "1107" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AKR1C4/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AKR1C4/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/AKR1C4/?format=api" } }, { "type": "Gene", "id": "GPRC6A", "attributes": { "go_molecular_function": [ "['G protein-coupled receptor activity']" ], "pathway_id": [ "kegg_path:hsa04621", "R-HSA-162582", "R-HSA-372790", "R-HSA-388396", "R-HSA-416476", "R-HSA-420499", "R-HSA-500792" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q5T6X5", "ensembl_id": "None", "entrez_id": "ENSG00000173612", "chromosome_number": "6", "lastmodified": "2023-05-16T12:02:33.486621" }, "relationships": { "variant_set": { "meta": { "count": 7 }, "data": [ { "type": "SmallVariant", "id": "3157" }, { "type": "SmallVariant", "id": "3183" }, { "type": "SmallVariant", "id": "3186" }, { "type": "SmallVariant", "id": "3202" }, { "type": "SmallVariant", "id": "3204" }, { "type": "SmallVariant", "id": "3239" }, { "type": "SmallVariant", "id": "3312" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GPRC6A/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GPRC6A/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 11 }, "data": [ { "type": "GeneCombination", "id": "1053" }, { "type": "GeneCombination", "id": "1063" }, { "type": "GeneCombination", "id": "1064" }, { "type": "GeneCombination", "id": "1069" }, { "type": "GeneCombination", "id": "1070" }, { "type": "GeneCombination", "id": "1085" }, { "type": "GeneCombination", "id": "1102" }, { "type": "GeneCombination", "id": "1105" }, { "type": "GeneCombination", "id": "1107" }, { "type": "GeneCombination", "id": "1111" }, { "type": "GeneCombination", "id": "1114" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GPRC6A/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GPRC6A/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GPRC6A/?format=api" } }, { "type": "Gene", "id": "MAP3K1", "attributes": { "go_molecular_function": [ "['protein kinase activity', 'zinc ion binding', 'protein kinase binding', 'protein serine/threonine kinase activity', 'ATP binding', 'MAP kinase kinase kinase activity', 'protein serine kinase activity', 'protein binding', 'protein serine/threonine/tyrosine kinase activity']" ], "pathway_id": [ "kegg_path:hsa04010", "kegg_path:hsa04120", "kegg_path:hsa04530", "kegg_path:hsa04622", "kegg_path:hsa04722", "kegg_path:hsa04912", "kegg_path:hsa04935", "kegg_path:hsa05161", "kegg_path:hsa05166", "R-HSA-166016", "R-HSA-166058", "R-HSA-168138", "R-HSA-168142", "R-HSA-168176", "R-HSA-168179", "R-HSA-168181", "R-HSA-168188", "R-HSA-168249", "R-HSA-168256", "R-HSA-168898", "R-HSA-168928", "R-HSA-181438", "R-HSA-2454202", "R-HSA-2871796", "R-HSA-933542", "R-HSA-975138", "R-HSA-975155", "R-HSA-975871" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q13233", "ensembl_id": "None", "entrez_id": "ENSG00000095015", "chromosome_number": "5", "lastmodified": "2021-10-18T11:00:44.832050" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "1696" }, { "type": "SmallVariant", "id": "2167" }, { "type": "SmallVariant", "id": "3161" }, { "type": "SmallVariant", "id": "3173" }, { "type": "SmallVariant", "id": "3289" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAP3K1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAP3K1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "554" }, { "type": "GeneCombination", "id": "737" }, { "type": "GeneCombination", "id": "1055" }, { "type": "GeneCombination", "id": "1060" }, { "type": "GeneCombination", "id": "1107" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAP3K1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAP3K1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MAP3K1/?format=api" } }, { "type": "Gene", "id": "ROR2", "attributes": { "go_molecular_function": [ "['Wnt-protein binding', 'mitogen-activated protein kinase kinase kinase binding', 'ATP binding', 'frizzled binding', 'protein binding', 'metal ion binding', 'coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway', 'protein serine/threonine/tyrosine kinase activity', 'transmembrane receptor protein tyrosine kinase activity']" ], "pathway_id": [ "kegg_path:hsa04310", "R-HSA-162582", "R-HSA-195721", "R-HSA-3858494", "R-HSA-4086400", "R-HSA-5140745" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q01974", "ensembl_id": "None", "entrez_id": "ENSG00000169071", "chromosome_number": "9", "lastmodified": "2021-10-18T11:00:44.743625" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "1531" }, { "type": "SmallVariant", "id": "1664" }, { "type": "SmallVariant", "id": "1669" }, { "type": "SmallVariant", "id": "3288" }, { "type": "SmallVariant", "id": "3313" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ROR2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ROR2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "491" }, { "type": "GeneCombination", "id": "541" }, { "type": "GeneCombination", "id": "543" }, { "type": "GeneCombination", "id": "1107" }, { "type": "GeneCombination", "id": "1114" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ROR2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ROR2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ROR2/?format=api" } }, { "type": "Gene", "id": "SLC29A3", "attributes": { "go_molecular_function": [ "['nucleoside transmembrane transporter activity', 'protein binding']" ], "pathway_id": [ "kegg_path:hsa05034", "R-HSA-1643685", "R-HSA-382551", "R-HSA-425397", "R-HSA-425407", "R-HSA-5619063", "R-HSA-5619102", "R-HSA-5619115", "R-HSA-83936" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q9BZD2", "ensembl_id": "None", "entrez_id": "ENSG00000198246", "chromosome_number": "10", "lastmodified": "2023-05-16T12:02:33.525136" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "3169" }, { "type": "SmallVariant", "id": "3179" }, { "type": "SmallVariant", "id": "3281" }, { "type": "SmallVariant", "id": "3290" }, { "type": "SmallVariant", "id": "3326" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SLC29A3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SLC29A3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "1058" }, { "type": "GeneCombination", "id": "1061" }, { "type": "GeneCombination", "id": "1104" }, { "type": "GeneCombination", "id": "1107" }, { "type": "GeneCombination", "id": "1117" }, { "type": "GeneCombination", "id": "1121" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SLC29A3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SLC29A3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SLC29A3/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 5 } }