Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1253/genes/?format=api
{ "data": [ { "type": "Gene", "id": "CHD7", "attributes": { "go_molecular_function": [ "['chromatin binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'protein binding', 'ATP hydrolysis activity', 'DNA helicase activity', 'promoter-specific chromatin binding', 'ATP binding']" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9P2D1", "ensembl_id": "None", "entrez_id": "ENSG00000171316", "chromosome_number": "8", "lastmodified": "2021-10-18T11:00:44.704701" }, "relationships": { "variant_set": { "meta": { "count": 70 }, "data": [ { "type": "SmallVariant", "id": "39" }, { "type": "SmallVariant", "id": "275" }, { "type": "SmallVariant", "id": "708" }, { "type": "SmallVariant", "id": "771" }, { "type": "SmallVariant", "id": "772" }, { "type": "SmallVariant", "id": "974" }, { "type": "SmallVariant", "id": "1158" }, { "type": "SmallVariant", "id": "1215" }, { "type": "SmallVariant", "id": "1495" }, { "type": "SmallVariant", "id": "1830" }, { "type": "SmallVariant", "id": "1853" }, { "type": "SmallVariant", "id": "1860" }, { "type": "SmallVariant", "id": "1882" }, { "type": "SmallVariant", "id": "1899" }, { "type": "SmallVariant", "id": "1905" }, { "type": "SmallVariant", "id": "1911" }, { "type": "SmallVariant", "id": "1912" }, { "type": "SmallVariant", "id": "1954" }, { "type": "SmallVariant", "id": "1968" }, { "type": "SmallVariant", "id": "2078" }, { "type": "SmallVariant", "id": "2401" }, { "type": "SmallVariant", "id": "2403" }, { "type": "SmallVariant", "id": "2494" }, { "type": "SmallVariant", "id": "2496" }, { "type": "SmallVariant", "id": "2500" }, { "type": "SmallVariant", "id": "2509" }, { "type": "SmallVariant", "id": "2518" }, { "type": "SmallVariant", "id": "2659" }, { "type": "SmallVariant", "id": "2661" }, { "type": "SmallVariant", "id": "2668" }, { "type": "SmallVariant", "id": "2674" }, { "type": "SmallVariant", "id": "2679" }, { "type": "SmallVariant", "id": "2702" }, { "type": "SmallVariant", "id": "2704" }, { "type": "SmallVariant", "id": "2706" }, { "type": "SmallVariant", "id": "2716" }, { "type": "SmallVariant", "id": "2720" }, { "type": "SmallVariant", "id": "2772" }, { "type": "SmallVariant", "id": "2818" }, { "type": "SmallVariant", "id": "2822" }, { "type": "SmallVariant", "id": "2823" }, { "type": "SmallVariant", "id": "2828" }, { "type": "SmallVariant", "id": "2837" }, { "type": "SmallVariant", "id": "2838" }, { "type": "SmallVariant", "id": "2841" }, { "type": "SmallVariant", "id": "2887" }, { "type": "SmallVariant", "id": "2932" }, { "type": "SmallVariant", "id": "2941" }, { "type": "SmallVariant", "id": "2945" }, { "type": "SmallVariant", "id": "2951" }, { "type": "SmallVariant", "id": "2952" }, { "type": "SmallVariant", "id": "2973" }, { "type": "SmallVariant", "id": "2986" }, { "type": "SmallVariant", "id": "3001" }, { "type": "SmallVariant", "id": "3005" }, { "type": "SmallVariant", "id": "3197" }, { "type": "SmallVariant", "id": "3223" }, { "type": "SmallVariant", "id": "3264" }, { "type": "SmallVariant", "id": "3321" }, { "type": "SmallVariant", "id": "3358" }, { "type": "SmallVariant", "id": "3359" }, { "type": "SmallVariant", "id": "3363" }, { "type": "SmallVariant", "id": "3376" }, { "type": "SmallVariant", "id": "3381" }, { "type": "SmallVariant", "id": "3384" }, { "type": "SmallVariant", "id": "3386" }, { "type": "SmallVariant", "id": "3472" }, { "type": "SmallVariant", "id": "3473" }, { "type": "SmallVariant", "id": "3475" }, { "type": "SmallVariant", "id": "3703" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CHD7/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CHD7/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 52 }, "data": [ { "type": "GeneCombination", "id": "16" }, { "type": "GeneCombination", "id": "98" }, { "type": "GeneCombination", "id": "227" }, { "type": "GeneCombination", "id": "242" }, { "type": "GeneCombination", "id": "371" }, { "type": "GeneCombination", "id": "387" }, { "type": "GeneCombination", "id": "478" }, { "type": "GeneCombination", "id": "618" }, { "type": "GeneCombination", "id": "627" }, { "type": "GeneCombination", "id": "634" }, { "type": "GeneCombination", "id": "636" }, { "type": "GeneCombination", "id": "639" }, { "type": "GeneCombination", "id": "643" }, { "type": "GeneCombination", "id": "661" }, { "type": "GeneCombination", "id": "666" }, { "type": "GeneCombination", "id": "675" }, { "type": "GeneCombination", "id": "891" }, { "type": "GeneCombination", "id": "718" }, { "type": "GeneCombination", "id": "819" }, { "type": "GeneCombination", "id": "845" }, { "type": "GeneCombination", "id": "847" }, { "type": "GeneCombination", "id": "818" }, { "type": "GeneCombination", "id": "885" }, { "type": "GeneCombination", "id": "606" }, { "type": "GeneCombination", "id": "888" }, { "type": "GeneCombination", "id": "892" }, { "type": "GeneCombination", "id": "899" }, { "type": "GeneCombination", "id": "312" }, { "type": "GeneCombination", "id": "846" }, { "type": "GeneCombination", "id": "939" }, { "type": "GeneCombination", "id": "941" }, { "type": "GeneCombination", "id": "944" }, { "type": "GeneCombination", "id": "945" }, { "type": "GeneCombination", "id": "949" }, { "type": "GeneCombination", "id": "956" }, { "type": "GeneCombination", "id": "974" }, { "type": "GeneCombination", "id": "978" }, { "type": "GeneCombination", "id": "980" }, { "type": "GeneCombination", "id": "982" }, { "type": "GeneCombination", "id": "990" }, { "type": "GeneCombination", "id": "1002" }, { "type": "GeneCombination", "id": "1003" }, { "type": "GeneCombination", "id": "1078" }, { "type": "GeneCombination", "id": "1080" }, { "type": "GeneCombination", "id": "1088" }, { "type": "GeneCombination", "id": "1097" }, { "type": "GeneCombination", "id": "1117" }, { "type": "GeneCombination", "id": "850" }, { "type": "GeneCombination", "id": "1165" }, { "type": "GeneCombination", "id": "1166" }, { "type": "GeneCombination", "id": "1167" }, { "type": "GeneCombination", "id": "1253" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CHD7/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CHD7/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CHD7/?format=api" } }, { "type": "Gene", "id": "GLI2", "attributes": { "go_molecular_function": [ "['zinc ion binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'sequence-specific double-stranded DNA binding', 'sequence-specific DNA binding', 'protein binding', 'DNA-binding transcription factor activity', 'promoter-specific chromatin binding', 'DNA-binding transcription factor activity, RNA polymerase II-specific']" ], "pathway_id": [ "kegg_path:hsa04340", "kegg_path:hsa04390", "kegg_path:hsa05200", "kegg_path:hsa05217", "R-HSA-162582", "R-HSA-212436", "R-HSA-5358351", "R-HSA-5610783", "R-HSA-5610787", "R-HSA-5632684", "R-HSA-5635851", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878166", "R-HSA-8941284", "R-HSA-8941326", "kegg_path:hsa04340", "kegg_path:hsa04390", "kegg_path:hsa05200", "kegg_path:hsa05217" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P10070", "ensembl_id": "None", "entrez_id": "ENSG00000074047", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.515380" }, "relationships": { "variant_set": { "meta": { "count": 14 }, "data": [ { "type": "SmallVariant", "id": "725" }, { "type": "SmallVariant", "id": "735" }, { "type": "SmallVariant", "id": "1217" }, { "type": "SmallVariant", "id": "1281" }, { "type": "SmallVariant", "id": "2493" }, { "type": "SmallVariant", "id": "2512" }, { "type": "SmallVariant", "id": "2514" }, { "type": "SmallVariant", "id": "3164" }, { "type": "SmallVariant", "id": "3199" }, { "type": "SmallVariant", "id": "3201" }, { "type": "SmallVariant", "id": "3213" }, { "type": "SmallVariant", "id": "3229" }, { "type": "SmallVariant", "id": "3265" }, { "type": "SmallVariant", "id": "3487" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GLI2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GLI2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 16 }, "data": [ { "type": "GeneCombination", "id": "232" }, { "type": "GeneCombination", "id": "235" }, { "type": "GeneCombination", "id": "407" }, { "type": "GeneCombination", "id": "387" }, { "type": "GeneCombination", "id": "844" }, { "type": "GeneCombination", "id": "852" }, { "type": "GeneCombination", "id": "853" }, { "type": "GeneCombination", "id": "1056" }, { "type": "GeneCombination", "id": "1068" }, { "type": "GeneCombination", "id": "1069" }, { "type": "GeneCombination", "id": "1081" }, { "type": "GeneCombination", "id": "1098" }, { "type": "GeneCombination", "id": "1102" }, { "type": "GeneCombination", "id": "1173" }, { "type": "GeneCombination", "id": "1074" }, { "type": "GeneCombination", "id": "1253" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GLI2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GLI2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GLI2/?format=api" } }, { "type": "Gene", "id": "MYO7A", "attributes": { "go_molecular_function": [ "['calmodulin binding', 'spectrin binding', 'protein binding', 'protein domain specific binding', 'microfilament motor activity', 'actin filament binding', 'ATP binding']" ], "pathway_id": [ "R-HSA-162582", "R-HSA-2187338", "R-HSA-2453902", "R-HSA-372790", "R-HSA-388396", "R-HSA-418594", "R-HSA-162582", "R-HSA-2187338", "R-HSA-2453902", "R-HSA-372790", "R-HSA-388396", "R-HSA-418594" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q13402", "ensembl_id": "None", "entrez_id": "ENSG00000137474", "chromosome_number": "11", "lastmodified": "2021-10-18T11:00:44.573189" }, "relationships": { "variant_set": { "meta": { "count": 28 }, "data": [ { "type": "SmallVariant", "id": "509" }, { "type": "SmallVariant", "id": "206" }, { "type": "SmallVariant", "id": "207" }, { "type": "SmallVariant", "id": "211" }, { "type": "SmallVariant", "id": "213" }, { "type": "SmallVariant", "id": "218" }, { "type": "SmallVariant", "id": "221" }, { "type": "SmallVariant", "id": "503" }, { "type": "SmallVariant", "id": "507" }, { "type": "SmallVariant", "id": "720" }, { "type": "SmallVariant", "id": "727" }, { "type": "SmallVariant", "id": "728" }, { "type": "SmallVariant", "id": "737" }, { "type": "SmallVariant", "id": "747" }, { "type": "SmallVariant", "id": "748" }, { "type": "SmallVariant", "id": "759" }, { "type": "SmallVariant", "id": "1323" }, { "type": "SmallVariant", "id": "1324" }, { "type": "SmallVariant", "id": "1975" }, { "type": "SmallVariant", "id": "2233" }, { "type": "SmallVariant", "id": "2235" }, { "type": "SmallVariant", "id": "2237" }, { "type": "SmallVariant", "id": "2239" }, { "type": "SmallVariant", "id": "2241" }, { "type": "SmallVariant", "id": "2243" }, { "type": "SmallVariant", "id": "2245" }, { "type": "SmallVariant", "id": "3704" }, { "type": "SmallVariant", "id": "3712" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MYO7A/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MYO7A/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 16 }, "data": [ { "type": "GeneCombination", "id": "75" }, { "type": "GeneCombination", "id": "76" }, { "type": "GeneCombination", "id": "77" }, { "type": "GeneCombination", "id": "78" }, { "type": "GeneCombination", "id": "80" }, { "type": "GeneCombination", "id": "236" }, { "type": "GeneCombination", "id": "240" }, { "type": "GeneCombination", "id": "168" }, { "type": "GeneCombination", "id": "238" }, { "type": "GeneCombination", "id": "231" }, { "type": "GeneCombination", "id": "233" }, { "type": "GeneCombination", "id": "412" }, { "type": "GeneCombination", "id": "758" }, { "type": "GeneCombination", "id": "757" }, { "type": "GeneCombination", "id": "1256" }, { "type": "GeneCombination", "id": "1253" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MYO7A/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MYO7A/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MYO7A/?format=api" } }, { "type": "Gene", "id": "VDR", "attributes": { "go_molecular_function": [ "['DNA binding', 'zinc ion binding', 'vitamin D response element binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'lithocholic acid receptor activity', 'retinoid X receptor binding', 'nuclear receptor activity', 'protein binding', 'calcitriol binding', 'DNA-binding transcription factor activity', 'lithocholic acid binding', 'DNA-binding transcription factor activity, RNA polymerase II-specific']" ], "pathway_id": [ "kegg_path:hsa04928", "kegg_path:hsa04961", "kegg_path:hsa04978", "kegg_path:hsa05152", "R-HSA-1430728", "R-HSA-196791", "R-HSA-212436", "R-HSA-2990846", "R-HSA-3108232", "R-HSA-383280", "R-HSA-392499", "R-HSA-4090294", "R-HSA-556833", "R-HSA-597592", "R-HSA-73857", "R-HSA-74160", "R-HSA-8957322" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P11473", "ensembl_id": "None", "entrez_id": "ENSG00000111424", "chromosome_number": "12", "lastmodified": "2024-02-29T15:02:20.992970" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3705" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/VDR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/VDR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "1253" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/VDR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/VDR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/VDR/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }