Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/401/genes/?format=api
{ "data": [ { "type": "Gene", "id": "GLIS3", "attributes": { "go_molecular_function": [ "['RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'DNA-binding transcription activator activity, RNA polymerase II-specific', 'DNA-binding transcription factor activity, RNA polymerase II-specific', 'protein binding', 'metal ion binding', 'DNA-binding transcription repressor activity, RNA polymerase II-specific']" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q8NEA6", "ensembl_id": "None", "entrez_id": "ENSG00000107249", "chromosome_number": "9", "lastmodified": "2021-10-18T11:00:44.803335" }, "relationships": { "variant_set": { "meta": { "count": 10 }, "data": [ { "type": "SmallVariant", "id": "1016" }, { "type": "SmallVariant", "id": "1233" }, { "type": "SmallVariant", "id": "1235" }, { "type": "SmallVariant", "id": "1236" }, { "type": "SmallVariant", "id": "1242" }, { "type": "SmallVariant", "id": "1259" }, { "type": "SmallVariant", "id": "1265" }, { "type": "SmallVariant", "id": "2352" }, { "type": "SmallVariant", "id": "3129" }, { "type": "SmallVariant", "id": "3146" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GLIS3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GLIS3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 8 }, "data": [ { "type": "GeneCombination", "id": "325" }, { "type": "GeneCombination", "id": "393" }, { "type": "GeneCombination", "id": "394" }, { "type": "GeneCombination", "id": "396" }, { "type": "GeneCombination", "id": "401" }, { "type": "GeneCombination", "id": "403" }, { "type": "GeneCombination", "id": "794" }, { "type": "GeneCombination", "id": "1046" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GLIS3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GLIS3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GLIS3/?format=api" } }, { "type": "Gene", "id": "PAX8", "attributes": { "go_molecular_function": [ "['thyroid-stimulating hormone receptor activity', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'DNA-binding transcription activator activity, RNA polymerase II-specific', 'transcription cis-regulatory region binding', 'DNA-binding transcription factor activity, RNA polymerase II-specific', 'DNA binding', 'sequence-specific double-stranded DNA binding', 'protein binding', 'DNA-binding transcription factor activity']" ], "pathway_id": [ "kegg_path:hsa04918", "kegg_path:hsa05200", "kegg_path:hsa05202", "kegg_path:hsa05216", "kegg_path:hsa04918", "kegg_path:hsa05200", "kegg_path:hsa05202", "kegg_path:hsa05216" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q06710", "ensembl_id": "None", "entrez_id": "ENSG00000125618", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.940585" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1255" }, { "type": "SmallVariant", "id": "1258" }, { "type": "SmallVariant", "id": "2379" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PAX8/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PAX8/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "400" }, { "type": "GeneCombination", "id": "401" }, { "type": "GeneCombination", "id": "808" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PAX8/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PAX8/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PAX8/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2024 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 2 } }