Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/221/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ADCY5", "attributes": { "go_molecular_function": [ "phosphorus-oxygen lyase activity", "adenylate cyclase activity" ], "pathway_id": [ "kegg_path:hsa04611", "kegg_path:hsa04213", "kegg_path:hsa04727", "R-HSA-163685", "kegg_path:hsa04912", "kegg_path:hsa04913", "R-HSA-9660821", "kegg_path:hsa04921", "kegg_path:hsa05034", "kegg_path:hsa04723", "R-HSA-170670", "R-HSA-372790", "R-HSA-445717", "R-HSA-9006925", "kegg_path:hsa04926", "kegg_path:hsa05032", "kegg_path:hsa05414", "kegg_path:hsa04916", "kegg_path:hsa04114", "kegg_path:hsa04914", "kegg_path:hsa01100", "R-HSA-418597", "kegg_path:hsa04062", "kegg_path:hsa04714", "R-HSA-112315", "kegg_path:hsa04923", "R-HSA-382551", "kegg_path:hsa04972", "R-HSA-381676", "R-HSA-5358351", "kegg_path:hsa04927", "R-HSA-1489509", "R-HSA-422356", "kegg_path:hsa04261", "R-HSA-112040", "R-HSA-112043", "kegg_path:hsa04270", "kegg_path:hsa04713", "kegg_path:hsa04970", "R-HSA-111931", "R-HSA-1643685", "kegg_path:hsa04935", "R-HSA-400042", "kegg_path:hsa04371", "kegg_path:hsa04725", "kegg_path:hsa04728", "R-HSA-111997", "R-HSA-111996", "kegg_path:hsa01522", "R-HSA-418594", "R-HSA-432040", "R-HSA-5663205", "kegg_path:hsa04928", "kegg_path:hsa05163", "R-HSA-9664433", "kegg_path:hsa05166", "R-HSA-991365", "R-HSA-164378", "R-HSA-162582", "R-HSA-163359", "R-HSA-163615", "R-HSA-5610787", "kegg_path:hsa04540", "kegg_path:hsa04726", "kegg_path:hsa04915", "R-HSA-977443", "kegg_path:hsa04976", "kegg_path:hsa05030", "kegg_path:hsa05200", "kegg_path:hsa04724", "R-HSA-9658195", "kegg_path:hsa04024", "kegg_path:hsa04925", "R-HSA-9664323", "kegg_path:hsa00230", "kegg_path:hsa04072", "kegg_path:hsa04918", "kegg_path:hsa04971", "R-HSA-1430728", "kegg_path:hsa05012", "kegg_path:hsa04911", "R-HSA-112314", "R-HSA-388396", "kegg_path:hsa04211", "kegg_path:hsa05031", "R-HSA-112316", "kegg_path:hsa04022", "R-HSA-111933", "R-HSA-111885", "R-HSA-418555", "kegg_path:hsa04934", "kegg_path:hsa04750", "R-HSA-170660", "kegg_path:hsa04924", "R-HSA-977444", "R-HSA-9662851", "kegg_path:hsa04015" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "O95622", "ensembl_id": "ENSG00000173175", "entrez_id": "111", "chromosome_number": "3", "lastmodified": "2021-10-18T11:00:44.808066" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "684" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ADCY5/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ADCY5/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "221" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ADCY5/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ADCY5/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ADCY5/?format=api" } }, { "type": "Gene", "id": "AHNAK", "attributes": { "go_molecular_function": [ "cadherin binding", "structural molecule activity conferring elasticity", "protein binding" ], "pathway_id": [ "kegg_path:hsa05132" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q09666", "ensembl_id": "ENSG00000124942", "entrez_id": "79026", "chromosome_number": "11", "lastmodified": "2021-10-18T11:00:44.772399" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "685" }, { "type": "SmallVariant", "id": "686" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AHNAK/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AHNAK/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "221" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AHNAK/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AHNAK/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/AHNAK/?format=api" } }, { "type": "Gene", "id": "ANG", "attributes": { "go_molecular_function": [ "protein binding", "endoribonuclease activity" ], "pathway_id": [ "R-HSA-446728", "R-HSA-418990", "kegg_path:hsa05014", "R-HSA-421270", "R-HSA-1500931" ], "essential_gene": null, "status": "CU", "uniprot_acc": "P03950", "ensembl_id": "ENSG00000214274", "entrez_id": "283", "chromosome_number": "14", "lastmodified": "2021-10-18T11:00:44.872102" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "532" }, { "type": "SmallVariant", "id": "542" }, { "type": "SmallVariant", "id": "681" }, { "type": "SmallVariant", "id": "1382" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ANG/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ANG/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "178" }, { "type": "GeneCombination", "id": "184" }, { "type": "GeneCombination", "id": "221" }, { "type": "GeneCombination", "id": "435" }, { "type": "GeneCombination", "id": "458" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ANG/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ANG/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ANG/?format=api" } }, { "type": "Gene", "id": "ATP7A", "attributes": { "go_molecular_function": [ "protein binding", "P-type monovalent copper transporter activity", "cuprous ion binding", "ATP binding", "copper-dependent protein binding", "copper ion binding" ], "pathway_id": [ "R-HSA-2262752", "R-HSA-936837", "R-HSA-6803544", "R-HSA-8953897", "R-HSA-3299685", "R-HSA-983712", "R-HSA-2262752", "R-HSA-936837", "R-HSA-6803544", "R-HSA-168256", "kegg_path:hsa04978", "R-HSA-8953897", "R-HSA-6803157", "kegg_path:hsa01524", "R-HSA-3299685", "R-HSA-983712", "R-HSA-168249", "kegg_path:hsa04978", "R-HSA-382551", "kegg_path:hsa01524", "R-HSA-168256", "kegg_path:hsa04978", "R-HSA-6803157", "kegg_path:hsa01524", "kegg_path:hsa04978", "R-HSA-168249", "R-HSA-382551", "kegg_path:hsa01524" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q04656", "ensembl_id": "ENSG00000165240", "entrez_id": "538", "chromosome_number": "X", "lastmodified": "2021-10-18T11:00:44.281268" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "687" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ATP7A/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ATP7A/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "221" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ATP7A/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ATP7A/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ATP7A/?format=api" } }, { "type": "Gene", "id": "KIAA1755", "attributes": { "go_molecular_function": [], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "Q5JYT7", "ensembl_id": "ENSG00000149633", "entrez_id": "85449", "chromosome_number": "20", "lastmodified": "2021-10-18T11:00:44.649590" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "682" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/KIAA1755/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/KIAA1755/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "221" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/KIAA1755/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/KIAA1755/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/KIAA1755/?format=api" } }, { "type": "Gene", "id": "KMT2C", "attributes": { "go_molecular_function": [ "['DNA binding', 'histone binding', 'protein binding', 'RNA binding', 'transcription coactivator activity', 'histone methyltransferase activity (H3-K4 specific)', 'acyltransferase activity', 'metal ion binding', 'histone methyltransferase activity']" ], "pathway_id": [ "kegg_path:hsa00310", "kegg_path:hsa01100", "R-HSA-1266738", "R-HSA-212436", "R-HSA-3214841", "R-HSA-3247509", "R-HSA-4839726", "R-HSA-5617472", "R-HSA-5619507", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878171", "R-HSA-8936459" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q8NEZ4", "ensembl_id": "None", "entrez_id": "ENSG00000055609", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:44.497998" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "683" }, { "type": "SmallVariant", "id": "3622" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/KMT2C/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/KMT2C/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "221" }, { "type": "GeneCombination", "id": "1218" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/KMT2C/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/KMT2C/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/KMT2C/?format=api" } }, { "type": "Gene", "id": "MYOM1", "attributes": { "go_molecular_function": [ "protein binding", "actin filament binding", "kinase binding", "protein homodimerization activity", "structural constituent of muscle", "identical protein binding" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "P52179", "ensembl_id": "ENSG00000101605", "entrez_id": "8736", "chromosome_number": "18", "lastmodified": "2021-10-18T11:00:44.595925" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "688" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MYOM1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MYOM1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "221" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MYOM1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MYOM1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MYOM1/?format=api" } }, { "type": "Gene", "id": "POU2F1", "attributes": { "go_molecular_function": [ "protein binding", "sequence-specific DNA binding" ], "pathway_id": [ "R-HSA-449147", "R-HSA-8939211", "R-HSA-9018519", "R-HSA-74160", "R-HSA-6785807", "R-HSA-74158", "R-HSA-162582", "R-HSA-168256", "R-HSA-749476", "R-HSA-1280215", "R-HSA-73857", "kegg_path:hsa05168", "R-HSA-76046", "R-HSA-6807505", "R-HSA-76071", "R-HSA-9006931" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P14859", "ensembl_id": "ENSG00000143190", "entrez_id": "5451", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.893363" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "643" }, { "type": "SmallVariant", "id": "689" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/POU2F1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/POU2F1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "216" }, { "type": "GeneCombination", "id": "221" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/POU2F1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/POU2F1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/POU2F1/?format=api" } }, { "type": "Gene", "id": "SOD1", "attributes": { "go_molecular_function": [ "['zinc ion binding', 'small GTPase binding', 'superoxide dismutase activity', 'protein binding', 'protein phosphatase 2B binding', 'copper ion binding', 'chaperone binding', 'identical protein binding']" ], "pathway_id": [ "kegg_path:hsa04146", "kegg_path:hsa04213", "kegg_path:hsa05014", "kegg_path:hsa05016", "kegg_path:hsa05020", "kegg_path:hsa05022", "R-HSA-109582", "R-HSA-114608", "R-HSA-1280215", "R-HSA-168256", "R-HSA-2262752", "R-HSA-3299685", "R-HSA-447115", "R-HSA-449147", "R-HSA-76002", "R-HSA-76005", "R-HSA-8950505", "R-HSA-8953897", "R-HSA-9020591" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P00441", "ensembl_id": "None", "entrez_id": "ENSG00000142168", "chromosome_number": "21", "lastmodified": "2021-10-18T11:00:44.427208" }, "relationships": { "variant_set": { "meta": { "count": 22 }, "data": [ { "type": "SmallVariant", "id": "1693" }, { "type": "SmallVariant", "id": "525" }, { "type": "SmallVariant", "id": "527" }, { "type": "SmallVariant", "id": "541" }, { "type": "SmallVariant", "id": "638" }, { "type": "SmallVariant", "id": "693" }, { "type": "SmallVariant", "id": "936" }, { "type": "SmallVariant", "id": "937" }, { "type": "SmallVariant", "id": "1379" }, { "type": "SmallVariant", "id": "1428" }, { "type": "SmallVariant", "id": "1709" }, { "type": "SmallVariant", "id": "2035" }, { "type": "SmallVariant", "id": "2039" }, { "type": "SmallVariant", "id": "2050" }, { "type": "SmallVariant", "id": "2189" }, { "type": "SmallVariant", "id": "3418" }, { "type": "SmallVariant", "id": "3426" }, { "type": "SmallVariant", "id": "3432" }, { "type": "SmallVariant", "id": "3446" }, { "type": "SmallVariant", "id": "3600" }, { "type": "SmallVariant", "id": "3603" }, { "type": "SmallVariant", "id": "3605" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SOD1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SOD1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 36 }, "data": [ { "type": "GeneCombination", "id": "173" }, { "type": "GeneCombination", "id": "174" }, { "type": "GeneCombination", "id": "184" }, { "type": "GeneCombination", "id": "216" }, { "type": "GeneCombination", "id": "217" }, { "type": "GeneCombination", "id": "218" }, { "type": "GeneCombination", "id": "219" }, { "type": "GeneCombination", "id": "220" }, { "type": "GeneCombination", "id": "221" }, { "type": "GeneCombination", "id": "222" }, { "type": "GeneCombination", "id": "223" }, { "type": "GeneCombination", "id": "297" }, { "type": "GeneCombination", "id": "298" }, { "type": "GeneCombination", "id": "434" }, { "type": "GeneCombination", "id": "451" }, { "type": "GeneCombination", "id": "552" }, { "type": "GeneCombination", "id": "559" }, { "type": "GeneCombination", "id": "561" }, { "type": "GeneCombination", "id": "562" }, { "type": "GeneCombination", "id": "699" }, { "type": "GeneCombination", "id": "700" }, { "type": "GeneCombination", "id": "701" }, { "type": "GeneCombination", "id": "702" }, { "type": "GeneCombination", "id": "706" }, { "type": "GeneCombination", "id": "727" }, { "type": "GeneCombination", "id": "726" }, { "type": "GeneCombination", "id": "725" }, { "type": "GeneCombination", "id": "724" }, { "type": "GeneCombination", "id": "723" }, { "type": "GeneCombination", "id": "722" }, { "type": "GeneCombination", "id": "721" }, { "type": "GeneCombination", "id": "747" }, { "type": "GeneCombination", "id": "1151" }, { "type": "GeneCombination", "id": "1154" }, { "type": "GeneCombination", "id": "1158" }, { "type": "GeneCombination", "id": "1212" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SOD1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SOD1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SOD1/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 9 } }