Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/937/genes/?format=api
{ "data": [ { "type": "Gene", "id": "GAL3ST2", "attributes": { "go_molecular_function": [ "['galactose 3-O-sulfotransferase activity', 'galactosylceramide sulfotransferase activity', 'protein binding', 'sulfotransferase activity']" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "Q9H3Q3", "ensembl_id": "None", "entrez_id": "ENSG00000154252", "chromosome_number": "2", "lastmodified": "2023-05-16T12:02:32.952665" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "2811" }, { "type": "SmallVariant", "id": "2812" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GAL3ST2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GAL3ST2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "937" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GAL3ST2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GAL3ST2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GAL3ST2/?format=api" } }, { "type": "Gene", "id": "HMCN1", "attributes": { "go_molecular_function": [ "['extracellular matrix structural constituent', 'calcium ion binding', 'protein binding']" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "Q96RW7", "ensembl_id": "None", "entrez_id": "ENSG00000143341", "chromosome_number": "1", "lastmodified": "2023-05-16T12:02:32.958047" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "2813" }, { "type": "SmallVariant", "id": "2814" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HMCN1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HMCN1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "937" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HMCN1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HMCN1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/HMCN1/?format=api" } }, { "type": "Gene", "id": "SIGLEC6", "attributes": { "go_molecular_function": [ "['sialic acid binding', 'carbohydrate binding', 'protein binding']" ], "pathway_id": [ "R-HSA-1280218", "R-HSA-168256", "R-HSA-198933" ], "essential_gene": null, "status": "CU", "uniprot_acc": "O43699", "ensembl_id": "None", "entrez_id": "ENSG00000105492", "chromosome_number": "19", "lastmodified": "2023-05-16T12:02:32.963630" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2815" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SIGLEC6/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SIGLEC6/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "937" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SIGLEC6/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SIGLEC6/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SIGLEC6/?format=api" } }, { "type": "Gene", "id": "STAT1", "attributes": { "go_molecular_function": [ "['tumor necrosis factor receptor binding', 'protein phosphatase 2A binding', 'DNA-binding transcription factor activity, RNA polymerase II-specific', 'double-stranded DNA binding', 'protein binding', 'histone binding', 'identical protein binding', 'DNA-binding transcription factor activity', 'transcription coactivator binding', 'ubiquitin-like protein ligase binding', 'nuclear receptor binding', 'RNA polymerase II transcription regulatory region sequence-specific DNA binding', 'histone acetyltransferase binding', 'cadherin binding', 'RNA polymerase II core promoter sequence-specific DNA binding', 'protein homodimerization activity', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'enzyme binding', 'CCR5 chemokine receptor binding', 'transcription corepressor binding', 'promoter-specific chromatin binding']" ], "pathway_id": [ "kegg_path:hsa04062", "kegg_path:hsa04217", "kegg_path:hsa04380", "kegg_path:hsa04620", "kegg_path:hsa04621", "kegg_path:hsa04625", "kegg_path:hsa04630", "kegg_path:hsa04658", "kegg_path:hsa04659", "kegg_path:hsa04917", "kegg_path:hsa04919", "kegg_path:hsa04933", "kegg_path:hsa04935", "kegg_path:hsa05140", "kegg_path:hsa05145", "kegg_path:hsa05152", "kegg_path:hsa05160", "kegg_path:hsa05161", "kegg_path:hsa05162", "kegg_path:hsa05164", "kegg_path:hsa05165", "kegg_path:hsa05167", "kegg_path:hsa05168", "kegg_path:hsa05169", "kegg_path:hsa05171", "kegg_path:hsa05200", "kegg_path:hsa05212", "kegg_path:hsa05235", "kegg_path:hsa05321", "R-HSA-1059683", "R-HSA-1169408", "R-HSA-1169410", "R-HSA-1226099", "R-HSA-1280215", "R-HSA-1433557", "R-HSA-157118", "R-HSA-162582", "R-HSA-1643685", "R-HSA-168256", "R-HSA-1839117", "R-HSA-1839124", "R-HSA-186763", "R-HSA-186797", "R-HSA-212436", "R-HSA-447115", "R-HSA-449147", "R-HSA-451927", "R-HSA-5655302", "R-HSA-5663202", "R-HSA-6783589", "R-HSA-6785807", "R-HSA-73857", "R-HSA-74160", "R-HSA-8854691", "R-HSA-8878166", "R-HSA-8939902", "R-HSA-8984722", "R-HSA-8985947", "R-HSA-9006934", "R-HSA-9012852", "R-HSA-9013508", "R-HSA-9020956", "R-HSA-9020958", "R-HSA-913531", "R-HSA-9669938", "R-HSA-9670439", "R-HSA-9671555", "R-HSA-9673767", "R-HSA-9673770", "R-HSA-982772" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P42224", "ensembl_id": "None", "entrez_id": "ENSG00000115415", "chromosome_number": "2", "lastmodified": "2023-05-16T12:02:32.946501" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "2808" }, { "type": "SmallVariant", "id": "2816" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/STAT1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/STAT1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "937" }, { "type": "GeneCombination", "id": "938" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/STAT1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/STAT1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/STAT1/?format=api" } }, { "type": "Gene", "id": "TTN", "attributes": { "go_molecular_function": [ "['enzyme binding', 'calmodulin binding', 'structural constituent of muscle', 'protein serine/threonine/tyrosine kinase activity', 'actinin binding', 'muscle alpha-actinin binding', 'protein kinase binding', 'telethonin binding', 'actin filament binding', 'identical protein binding', 'calcium ion binding', 'structural molecule activity conferring elasticity', 'protein serine kinase activity', 'ATP binding', 'protein tyrosine kinase activity', 'protein self-association', 'protein binding', 'protease binding', 'protein serine/threonine kinase activity']" ], "pathway_id": [ "kegg_path:hsa05410", "kegg_path:hsa05414", "R-HSA-109582", "R-HSA-114608", "R-HSA-390522", "R-HSA-397014", "R-HSA-76002", "R-HSA-76005" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "A0A0A0MTS7", "ensembl_id": "None", "entrez_id": "ENSG00000155657", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.407776" }, "relationships": { "variant_set": { "meta": { "count": 20 }, "data": [ { "type": "SmallVariant", "id": "449" }, { "type": "SmallVariant", "id": "450" }, { "type": "SmallVariant", "id": "452" }, { "type": "SmallVariant", "id": "453" }, { "type": "SmallVariant", "id": "455" }, { "type": "SmallVariant", "id": "462" }, { "type": "SmallVariant", "id": "463" }, { "type": "SmallVariant", "id": "1451" }, { "type": "SmallVariant", "id": "2019" }, { "type": "SmallVariant", "id": "2782" }, { "type": "SmallVariant", "id": "2785" }, { "type": "SmallVariant", "id": "2809" }, { "type": "SmallVariant", "id": "2810" }, { "type": "SmallVariant", "id": "3529" }, { "type": "SmallVariant", "id": "3534" }, { "type": "SmallVariant", "id": "3560" }, { "type": "SmallVariant", "id": "3570" }, { "type": "SmallVariant", "id": "3760" }, { "type": "SmallVariant", "id": "3762" }, { "type": "SmallVariant", "id": "3764" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TTN/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TTN/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 16 }, "data": [ { "type": "GeneCombination", "id": "148" }, { "type": "GeneCombination", "id": "149" }, { "type": "GeneCombination", "id": "150" }, { "type": "GeneCombination", "id": "153" }, { "type": "GeneCombination", "id": "463" }, { "type": "GeneCombination", "id": "695" }, { "type": "GeneCombination", "id": "930" }, { "type": "GeneCombination", "id": "931" }, { "type": "GeneCombination", "id": "937" }, { "type": "GeneCombination", "id": "1190" }, { "type": "GeneCombination", "id": "1191" }, { "type": "GeneCombination", "id": "1198" }, { "type": "GeneCombination", "id": "1202" }, { "type": "GeneCombination", "id": "1272" }, { "type": "GeneCombination", "id": "1273" }, { "type": "GeneCombination", "id": "1274" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TTN/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TTN/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/TTN/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 5 } }