Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/770/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ATM", "attributes": { "go_molecular_function": [ "DNA-dependent protein kinase activity", "protein binding", "identical protein binding", "protein serine/threonine kinase activity", "DNA binding", "1-phosphatidylinositol-3-kinase activity", "protein serine/threonine/tyrosine kinase activity", "protein N-terminus binding", "ATP binding", "protein serine kinase activity", "protein-containing complex binding" ], "pathway_id": [ "kegg_path:hsa04210", "R-HSA-2559583", "kegg_path:hsa05202", "kegg_path:hsa05206", "R-HSA-1474165", "kegg_path:hsa01524", "R-HSA-5693565", "R-HSA-5693568", "kegg_path:hsa04064", "kegg_path:hsa04068", "R-HSA-5693537", "kegg_path:hsa05170", "R-HSA-73857", "R-HSA-69580", "kegg_path:hsa05165", "R-HSA-5693616", "R-HSA-9663891", "R-HSA-5685938", "R-HSA-912446", "kegg_path:hsa04115", "R-HSA-6803204", "R-HSA-6803207", "R-HSA-3371556", "R-HSA-5693606", "R-HSA-212436", "R-HSA-1640170", "R-HSA-3371453", "kegg_path:hsa04115", "R-HSA-5693548", "R-HSA-349425", "R-HSA-5693607", "kegg_path:hsa05165", "R-HSA-5633007", "R-HSA-5693554", "R-HSA-6804757", "R-HSA-69615", "R-HSA-6804756", "R-HSA-73894", "R-HSA-6806003", "kegg_path:hsa04110", "R-HSA-5693571", "R-HSA-6804760", "R-HSA-69541", "R-HSA-9664873", "kegg_path:hsa04110", "R-HSA-2559586", "R-HSA-5693538", "R-HSA-69563", "kegg_path:hsa05166", "R-HSA-8953897", "R-HSA-1500620", "R-HSA-5633008", "R-HSA-5693532", "R-HSA-6796648", "R-HSA-74160", "kegg_path:hsa04218", "kegg_path:hsa03440", "kegg_path:hsa05131", "R-HSA-2262752", "kegg_path:hsa04218", "R-HSA-3700989", "R-HSA-5685942", "kegg_path:hsa05131", "kegg_path:hsa03440", "R-HSA-1632852", "R-HSA-69481", "kegg_path:hsa05166", "R-HSA-9612973", "R-HSA-5693579", "kegg_path:hsa05170", "R-HSA-69473", "kegg_path:hsa04064", "kegg_path:hsa04068", "kegg_path:hsa05206", "R-HSA-69620", "kegg_path:hsa01524", "R-HSA-5693567", "kegg_path:hsa05202", "kegg_path:hsa04210" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q13315", "ensembl_id": "ENSG00000149311", "entrez_id": "472", "chromosome_number": "11", "lastmodified": "2022-08-04T14:14:58.235652" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "2253" }, { "type": "SmallVariant", "id": "2294" }, { "type": "SmallVariant", "id": "2313" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ATM/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ATM/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "760" }, { "type": "GeneCombination", "id": "770" }, { "type": "GeneCombination", "id": "777" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ATM/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ATM/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ATM/?format=api" } }, { "type": "Gene", "id": "NCOR2", "attributes": { "go_molecular_function": [ "Notch binding", "protein binding", "DNA binding", "glucocorticoid receptor binding", "protein N-terminus binding", "transcription corepressor activity", "histone deacetylase binding", "chromatin binding", "retinoid X receptor binding", "protein-containing complex binding" ], "pathway_id": [ "R-HSA-2644603", "R-HSA-2894858", "R-HSA-157118", "R-HSA-9697154", "R-HSA-2173793", "R-HSA-9029569", "R-HSA-170834", "kegg_path:hsa05169", "R-HSA-1643685", "R-HSA-2173795", "R-HSA-9675151", "R-HSA-3247509", "R-HSA-9022692", "R-HSA-1266738", "R-HSA-3214815", "R-HSA-400206", "R-HSA-212436", "R-HSA-5663205", "R-HSA-9006931", "R-HSA-2122947", "R-HSA-2990846", "R-HSA-3108232", "R-HSA-556833", "R-HSA-9024446", "R-HSA-9005891", "R-HSA-350054", "R-HSA-5663202", "R-HSA-74160", "R-HSA-9022537", "R-HSA-9609690", "R-HSA-597592", "R-HSA-9006936", "kegg_path:hsa04330", "R-HSA-4839726", "R-HSA-162582", "R-HSA-1980143", "R-HSA-9609646", "R-HSA-383280", "R-HSA-1430728", "R-HSA-73857", "R-HSA-8986944", "R-HSA-1989781", "R-HSA-9623433", "R-HSA-2894862", "R-HSA-9005895", "R-HSA-3899300", "R-HSA-381340", "R-HSA-392499", "R-HSA-2644602", "R-HSA-2644606" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9Y618", "ensembl_id": "ENSG00000196498", "entrez_id": "9612", "chromosome_number": "12", "lastmodified": "2022-08-04T14:14:58.085323" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "2122" }, { "type": "SmallVariant", "id": "2258" }, { "type": "SmallVariant", "id": "2270" }, { "type": "SmallVariant", "id": "2295" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NCOR2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NCOR2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "731" }, { "type": "GeneCombination", "id": "761" }, { "type": "GeneCombination", "id": "763" }, { "type": "GeneCombination", "id": "770" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NCOR2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NCOR2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NCOR2/?format=api" } }, { "type": "Gene", "id": "POLG", "attributes": { "go_molecular_function": [ "protease binding", "protein binding", "DNA-directed DNA polymerase activity", "DNA binding", "chromatin binding", "3'-5' exonuclease activity" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P54098", "ensembl_id": "ENSG00000140521", "entrez_id": "5428", "chromosome_number": "15", "lastmodified": "2021-10-18T11:00:44.585795" }, "relationships": { "variant_set": { "meta": { "count": 7 }, "data": [ { "type": "SmallVariant", "id": "235" }, { "type": "SmallVariant", "id": "272" }, { "type": "SmallVariant", "id": "1996" }, { "type": "SmallVariant", "id": "2229" }, { "type": "SmallVariant", "id": "2296" }, { "type": "SmallVariant", "id": "2297" }, { "type": "SmallVariant", "id": "2308" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/POLG/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/POLG/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "86" }, { "type": "GeneCombination", "id": "687" }, { "type": "GeneCombination", "id": "755" }, { "type": "GeneCombination", "id": "770" }, { "type": "GeneCombination", "id": "773" }, { "type": "GeneCombination", "id": "775" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/POLG/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/POLG/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/POLG/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }