Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1255/genes/?format=api
{ "data": [ { "type": "Gene", "id": "PKD1", "attributes": { "go_molecular_function": [ "['protein kinase binding', 'protein binding', 'transmembrane transporter binding', 'protein domain specific binding', 'calcium channel activity', 'carbohydrate binding', 'Wnt-activated receptor activity']" ], "pathway_id": [ "R-HSA-1852241", "R-HSA-5617833", "R-HSA-5620916", "R-HSA-5620920" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P98161", "ensembl_id": "None", "entrez_id": "ENSG00000008710", "chromosome_number": "16", "lastmodified": "2021-10-18T11:00:44.534851" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "636" }, { "type": "SmallVariant", "id": "2081" }, { "type": "SmallVariant", "id": "3615" }, { "type": "SmallVariant", "id": "3709" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PKD1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PKD1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "215" }, { "type": "GeneCombination", "id": "720" }, { "type": "GeneCombination", "id": "1255" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PKD1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PKD1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PKD1/?format=api" } }, { "type": "Gene", "id": "POR", "attributes": { "go_molecular_function": [ "['NADPH-hemoprotein reductase activity', 'nitric oxide dioxygenase activity', 'hydrolase activity', 'enzyme binding', 'oxidoreductase activity', 'NADP binding', 'flavin adenine dinucleotide binding', 'electron transfer activity', 'protein binding', 'cytochrome-b5 reductase activity, acting on NAD(P)H', 'iron-cytochrome-c reductase activity', 'FMN binding']" ], "pathway_id": [ "R-HSA-1430728", "R-HSA-211859", "R-HSA-211897", "R-HSA-211945", "R-HSA-1430728", "R-HSA-211859", "R-HSA-211897", "R-HSA-211945" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P16435", "ensembl_id": "None", "entrez_id": "ENSG00000127948", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:44.656385" }, "relationships": { "variant_set": { "meta": { "count": 7 }, "data": [ { "type": "SmallVariant", "id": "707" }, { "type": "SmallVariant", "id": "1205" }, { "type": "SmallVariant", "id": "2166" }, { "type": "SmallVariant", "id": "2178" }, { "type": "SmallVariant", "id": "3205" }, { "type": "SmallVariant", "id": "3315" }, { "type": "SmallVariant", "id": "3708" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/POR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/POR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 7 }, "data": [ { "type": "GeneCombination", "id": "226" }, { "type": "GeneCombination", "id": "385" }, { "type": "GeneCombination", "id": "737" }, { "type": "GeneCombination", "id": "742" }, { "type": "GeneCombination", "id": "1070" }, { "type": "GeneCombination", "id": "1115" }, { "type": "GeneCombination", "id": "1255" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/POR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/POR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/POR/?format=api" } }, { "type": "Gene", "id": "SOX9", "attributes": { "go_molecular_function": [ "['chromatin binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'beta-catenin binding', 'pre-mRNA intronic binding', 'sequence-specific double-stranded DNA binding', 'cis-regulatory region sequence-specific DNA binding', 'sequence-specific DNA binding', 'protein binding', 'bHLH transcription factor binding', 'DNA-binding transcription activator activity, RNA polymerase II-specific', 'DNA-binding transcription factor activity', 'protein kinase A catalytic subunit binding', 'DNA-binding transcription factor activity, RNA polymerase II-specific']" ], "pathway_id": [ "kegg_path:hsa04024", "R-HSA-1266738", "R-HSA-162582", "R-HSA-195721", "R-HSA-201681", "R-HSA-212436", "R-HSA-3769402", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878166", "R-HSA-9690406" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P48436", "ensembl_id": "None", "entrez_id": "ENSG00000125398", "chromosome_number": "17", "lastmodified": "2023-05-16T12:02:32.822287" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "2778" }, { "type": "SmallVariant", "id": "3711" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SOX9/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SOX9/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "929" }, { "type": "GeneCombination", "id": "1255" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SOX9/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SOX9/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SOX9/?format=api" } }, { "type": "Gene", "id": "SRCAP", "attributes": { "go_molecular_function": [ "['DNA binding', 'histone binding', 'histone acetyltransferase activity', 'protein binding', 'transcription coactivator activity', 'helicase activity', 'ATP hydrolysis activity', 'ATP binding']" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "Q6ZRS2", "ensembl_id": "None", "entrez_id": "ENSG00000080603", "chromosome_number": "16", "lastmodified": "2024-02-29T15:02:21.010445" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3710" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SRCAP/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SRCAP/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "1255" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SRCAP/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SRCAP/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SRCAP/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }