Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/827/genes/?format=api
{ "data": [ { "type": "Gene", "id": "CFTR", "attributes": { "go_molecular_function": [ "intracellularly ATP-gated chloride channel activity", "ATPase-coupled transmembrane transporter activity", "protein binding", "ATP hydrolysis activity", "chloride transmembrane transporter activity", "enzyme binding", "isomerase activity", "ATPase-coupled inorganic anion transmembrane transporter activity", "Sec61 translocon complex binding", "chaperone binding", "bicarbonate transmembrane transporter activity", "chloride channel inhibitor activity", "PDZ domain binding", "chloride channel activity", "chloride channel regulator activity", "ATP binding", "ABC-type transporter activity" ], "pathway_id": [ "R-HSA-5619084", "R-HSA-5627083", "R-HSA-9615710", "R-HSA-194315", "R-HSA-162582", "R-HSA-5678895", "R-HSA-9663891", "kegg_path:hsa04976", "kegg_path:hsa04976", "R-HSA-597592", "kegg_path:hsa04152", "kegg_path:hsa05110", "kegg_path:hsa04152", "kegg_path:hsa05110", "kegg_path:hsa04024", "kegg_path:hsa04024", "R-HSA-195258", "R-HSA-9613829", "R-HSA-5619115", "R-HSA-5653656", "R-HSA-8856828", "kegg_path:hsa04971", "kegg_path:hsa04971", "R-HSA-5688426", "R-HSA-382551", "kegg_path:hsa04530", "kegg_path:hsa04972", "kegg_path:hsa04530", "kegg_path:hsa04972", "R-HSA-382556", "R-HSA-9646399", "R-HSA-8856825", "kegg_path:hsa02010", "kegg_path:hsa02010", "R-HSA-1643685", "R-HSA-392499", "R-HSA-1632852", "R-HSA-199991", "R-HSA-9612973", "R-HSA-5689880" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P13569", "ensembl_id": "ENSG00000001626", "entrez_id": "1080", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:44.472577" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "1759" }, { "type": "SmallVariant", "id": "1761" }, { "type": "SmallVariant", "id": "1763" }, { "type": "SmallVariant", "id": "2451" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CFTR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CFTR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "580" }, { "type": "GeneCombination", "id": "581" }, { "type": "GeneCombination", "id": "582" }, { "type": "GeneCombination", "id": "827" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CFTR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CFTR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CFTR/?format=api" } }, { "type": "Gene", "id": "SHOX", "attributes": { "go_molecular_function": [ "protein binding", "DNA-binding transcription factor activity, RNA polymerase II-specific", "DNA-binding transcription activator activity, RNA polymerase II-specific", "sequence-specific double-stranded DNA binding", "sequence-specific DNA binding" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "O15266", "ensembl_id": "ENSG00000185960", "entrez_id": "6473", "chromosome_number": "X", "lastmodified": "2022-08-04T14:14:58.402497" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "2452" }, { "type": "SmallVariant", "id": "2462" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SHOX/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SHOX/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "827" }, { "type": "GeneCombination", "id": "831" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SHOX/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SHOX/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SHOX/?format=api" } }, { "type": "Gene", "id": "ZNF263", "attributes": { "go_molecular_function": [ "protein binding", "DNA-binding transcription factor activity, RNA polymerase II-specific", "transcription cis-regulatory region binding", "DNA-binding transcription repressor activity, RNA polymerase II-specific", "metal ion binding", "sequence-specific double-stranded DNA binding", "DNA-binding transcription factor activity", "sequence-specific DNA binding", "RNA polymerase II cis-regulatory region sequence-specific DNA binding" ], "pathway_id": [ "R-HSA-74160", "R-HSA-73857", "R-HSA-212436" ], "essential_gene": null, "status": "CU", "uniprot_acc": "O14978", "ensembl_id": "ENSG00000006194", "entrez_id": "10127", "chromosome_number": "16", "lastmodified": "2022-08-04T14:14:59.825311" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2453" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ZNF263/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ZNF263/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "827" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ZNF263/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ZNF263/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ZNF263/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }