Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/172/genes/?format=api
{ "data": [ { "type": "Gene", "id": "DSC2", "attributes": { "go_molecular_function": [ "['cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication', 'calcium ion binding', 'protein binding']" ], "pathway_id": [ "kegg_path:hsa05412", "R-HSA-1266738", "R-HSA-6805567", "R-HSA-6809371" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q02487", "ensembl_id": "None", "entrez_id": "ENSG00000134755", "chromosome_number": "18", "lastmodified": "2021-10-18T11:00:44.944986" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "523" }, { "type": "SmallVariant", "id": "1404" }, { "type": "SmallVariant", "id": "3766" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/DSC2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/DSC2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "172" }, { "type": "GeneCombination", "id": "441" }, { "type": "GeneCombination", "id": "1275" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/DSC2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/DSC2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/DSC2/?format=api" } }, { "type": "Gene", "id": "DSG2", "attributes": { "go_molecular_function": [ "metal ion binding", "calcium ion binding" ], "pathway_id": [ "R-HSA-75153", "R-HSA-6805567", "kegg_path:hsa05412", "R-HSA-6809371", "R-HSA-1266738", "R-HSA-5357801", "R-HSA-109581", "R-HSA-111465", "R-HSA-351906" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q14126", "ensembl_id": "ENSG00000046604", "entrez_id": "1829", "chromosome_number": "18", "lastmodified": "2021-10-18T11:00:44.528431" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "524" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/DSG2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/DSG2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "172" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/DSG2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/DSG2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/DSG2/?format=api" } }, { "type": "Gene", "id": "MYH6", "attributes": { "go_molecular_function": [ "protein kinase binding", "ATP binding", "actin filament binding", "calmodulin binding", "microfilament motor activity", "myosin phosphatase activity" ], "pathway_id": [ "kegg_path:hsa04261", "kegg_path:hsa05414", "kegg_path:hsa04919", "R-HSA-390522", "kegg_path:hsa04260", "kegg_path:hsa05416", "R-HSA-397014", "kegg_path:hsa04022", "kegg_path:hsa05410" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P13533", "ensembl_id": "ENSG00000197616", "entrez_id": "4624", "chromosome_number": "14", "lastmodified": "2021-10-18T11:00:44.639203" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "522" }, { "type": "SmallVariant", "id": "2170" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MYH6/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MYH6/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "172" }, { "type": "GeneCombination", "id": "738" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MYH6/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MYH6/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MYH6/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2024 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }