Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1061/genes/?format=api
{ "data": [ { "type": "Gene", "id": "FLNA", "attributes": { "go_molecular_function": [ "['RNA binding', 'Fc-gamma receptor I complex binding', 'small GTPase binding', 'actin filament binding', 'protein kinase C binding', 'transmembrane transporter binding', 'cadherin binding', 'potassium channel regulator activity', 'kinase binding', 'G protein-coupled receptor binding', 'protein binding', 'GTPase binding', 'protein homodimerization activity', 'DNA-binding transcription factor binding']" ], "pathway_id": [ "kegg_path:hsa04010", "kegg_path:hsa04510", "kegg_path:hsa05132", "kegg_path:hsa05205", "R-HSA-109582", "R-HSA-114608", "R-HSA-1169410", "R-HSA-1280215", "R-HSA-1500931", "R-HSA-162582", "R-HSA-168256", "R-HSA-194315", "R-HSA-195258", "R-HSA-430116", "R-HSA-446353", "R-HSA-446728", "R-HSA-5627123", "R-HSA-76002", "R-HSA-76005", "R-HSA-8983711", "R-HSA-913531", "kegg_path:hsa04010", "kegg_path:hsa04510", "kegg_path:hsa05132", "kegg_path:hsa05205", "kegg_path:hsa04010", "kegg_path:hsa04510", "kegg_path:hsa05132", "kegg_path:hsa05205", "kegg_path:hsa04010", "kegg_path:hsa04510", "kegg_path:hsa05132", "kegg_path:hsa05205", "R-HSA-109582", "R-HSA-114608", "R-HSA-1169410", "R-HSA-1280215", "R-HSA-1500931", "R-HSA-162582", "R-HSA-168256", "R-HSA-194315", "R-HSA-195258", "R-HSA-430116", "R-HSA-446353", "R-HSA-446728", "R-HSA-5627123", "R-HSA-76002", "R-HSA-76005", "R-HSA-8983711", "R-HSA-913531", "kegg_path:hsa04010", "kegg_path:hsa04510", "kegg_path:hsa05132", "kegg_path:hsa05205", "kegg_path:hsa04010", "kegg_path:hsa04510", "kegg_path:hsa05132", "kegg_path:hsa05205" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P21333", "ensembl_id": "None", "entrez_id": "ENSG00000196924", "chromosome_number": "X", "lastmodified": "2021-10-18T11:00:44.390873" }, "relationships": { "variant_set": { "meta": { "count": 6 }, "data": [ { "type": "SmallVariant", "id": "767" }, { "type": "SmallVariant", "id": "1298" }, { "type": "SmallVariant", "id": "3177" }, { "type": "SmallVariant", "id": "3241" }, { "type": "SmallVariant", "id": "3277" }, { "type": "SmallVariant", "id": "3314" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FLNA/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FLNA/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "240" }, { "type": "GeneCombination", "id": "410" }, { "type": "GeneCombination", "id": "1061" }, { "type": "GeneCombination", "id": "1086" }, { "type": "GeneCombination", "id": "1102" }, { "type": "GeneCombination", "id": "1114" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FLNA/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FLNA/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FLNA/?format=api" } }, { "type": "Gene", "id": "GLI3", "attributes": { "go_molecular_function": [ "['chromatin binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'beta-catenin binding', 'metal ion binding', 'histone acetyltransferase binding', 'sequence-specific double-stranded DNA binding', 'DNA-binding transcription factor activity, RNA polymerase II-specific', 'mediator complex binding', 'protein binding', 'RNA polymerase II transcription regulatory region sequence-specific DNA binding', 'histone deacetylase binding', 'DNA-binding transcription factor activity']" ], "pathway_id": [ "kegg_path:hsa04024", "kegg_path:hsa04340", "kegg_path:hsa05200", "kegg_path:hsa05217", "R-HSA-162582", "R-HSA-212436", "R-HSA-5358351", "R-HSA-5610785", "R-HSA-5610787", "R-HSA-5632684", "R-HSA-5635851", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878166", "R-HSA-8940973", "R-HSA-8941326" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P10071", "ensembl_id": "None", "entrez_id": "ENSG00000106571", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:44.894304" }, "relationships": { "variant_set": { "meta": { "count": 16 }, "data": [ { "type": "SmallVariant", "id": "726" }, { "type": "SmallVariant", "id": "731" }, { "type": "SmallVariant", "id": "732" }, { "type": "SmallVariant", "id": "741" }, { "type": "SmallVariant", "id": "900" }, { "type": "SmallVariant", "id": "916" }, { "type": "SmallVariant", "id": "1300" }, { "type": "SmallVariant", "id": "2769" }, { "type": "SmallVariant", "id": "2834" }, { "type": "SmallVariant", "id": "2847" }, { "type": "SmallVariant", "id": "2889" }, { "type": "SmallVariant", "id": "2963" }, { "type": "SmallVariant", "id": "3180" }, { "type": "SmallVariant", "id": "3214" }, { "type": "SmallVariant", "id": "3230" }, { "type": "SmallVariant", "id": "3324" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GLI3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GLI3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 16 }, "data": [ { "type": "GeneCombination", "id": "236" }, { "type": "GeneCombination", "id": "232" }, { "type": "GeneCombination", "id": "234" }, { "type": "GeneCombination", "id": "287" }, { "type": "GeneCombination", "id": "279" }, { "type": "GeneCombination", "id": "410" }, { "type": "GeneCombination", "id": "926" }, { "type": "GeneCombination", "id": "942" }, { "type": "GeneCombination", "id": "957" }, { "type": "GeneCombination", "id": "986" }, { "type": "GeneCombination", "id": "1061" }, { "type": "GeneCombination", "id": "1081" }, { "type": "GeneCombination", "id": "1115" }, { "type": "GeneCombination", "id": "1118" }, { "type": "GeneCombination", "id": "1120" }, { "type": "GeneCombination", "id": "1074" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GLI3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GLI3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GLI3/?format=api" } }, { "type": "Gene", "id": "NIPBL", "attributes": { "go_molecular_function": [ "['protein N-terminus binding', 'chromatin binding', 'chromo shadow domain binding', 'mediator complex binding', 'protein C-terminus binding', 'protein binding', 'promoter-specific chromatin binding', 'histone deacetylase binding']" ], "pathway_id": [ "R-HSA-1640170", "R-HSA-2470946", "R-HSA-68884", "R-HSA-68886", "R-HSA-69278" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q6KC79", "ensembl_id": "None", "entrez_id": "ENSG00000164190", "chromosome_number": "5", "lastmodified": "2023-05-16T12:02:33.550141" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "3178" }, { "type": "SmallVariant", "id": "3331" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NIPBL/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NIPBL/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "1061" }, { "type": "GeneCombination", "id": "1123" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NIPBL/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NIPBL/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NIPBL/?format=api" } }, { "type": "Gene", "id": "PLXNA3", "attributes": { "go_molecular_function": [ "['semaphorin receptor activity', 'protein binding']" ], "pathway_id": [ "kegg_path:hsa04360", "R-HSA-1266738", "R-HSA-373755", "R-HSA-399954", "R-HSA-399955", "R-HSA-399956", "R-HSA-422475", "R-HSA-9675108", "kegg_path:hsa04360", "R-HSA-1266738", "R-HSA-373755", "R-HSA-399954", "R-HSA-399955", "R-HSA-399956", "R-HSA-422475", "R-HSA-9675108" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P51805", "ensembl_id": "None", "entrez_id": "ENSG00000130827", "chromosome_number": "X", "lastmodified": "2023-05-16T12:02:33.541810" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "3176" }, { "type": "SmallVariant", "id": "3211" }, { "type": "SmallVariant", "id": "3217" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PLXNA3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PLXNA3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "1061" }, { "type": "GeneCombination", "id": "1073" }, { "type": "GeneCombination", "id": "1076" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PLXNA3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PLXNA3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PLXNA3/?format=api" } }, { "type": "Gene", "id": "PROKR2", "attributes": { "go_molecular_function": [ "['neuropeptide Y receptor activity', 'protein binding', 'G protein-coupled receptor activity']" ], "pathway_id": [ "R-HSA-162582", "R-HSA-372790", "R-HSA-373076", "R-HSA-375276", "R-HSA-388396", "R-HSA-416476", "R-HSA-500792" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "None", "ensembl_id": "None", "entrez_id": "ENSG00000101292", "chromosome_number": "20", "lastmodified": "2021-10-18T11:00:44.395103" }, "relationships": { "variant_set": { "meta": { "count": 38 }, "data": [ { "type": "SmallVariant", "id": "26" }, { "type": "SmallVariant", "id": "78" }, { "type": "SmallVariant", "id": "331" }, { "type": "SmallVariant", "id": "383" }, { "type": "SmallVariant", "id": "397" }, { "type": "SmallVariant", "id": "400" }, { "type": "SmallVariant", "id": "402" }, { "type": "SmallVariant", "id": "857" }, { "type": "SmallVariant", "id": "1057" }, { "type": "SmallVariant", "id": "1798" }, { "type": "SmallVariant", "id": "1825" }, { "type": "SmallVariant", "id": "1826" }, { "type": "SmallVariant", "id": "1857" }, { "type": "SmallVariant", "id": "1864" }, { "type": "SmallVariant", "id": "1888" }, { "type": "SmallVariant", "id": "1892" }, { "type": "SmallVariant", "id": "1898" }, { "type": "SmallVariant", "id": "1901" }, { "type": "SmallVariant", "id": "1931" }, { "type": "SmallVariant", "id": "2398" }, { "type": "SmallVariant", "id": "2399" }, { "type": "SmallVariant", "id": "2502" }, { "type": "SmallVariant", "id": "2513" }, { "type": "SmallVariant", "id": "2517" }, { "type": "SmallVariant", "id": "2577" }, { "type": "SmallVariant", "id": "2579" }, { "type": "SmallVariant", "id": "2662" }, { "type": "SmallVariant", "id": "2678" }, { "type": "SmallVariant", "id": "2691" }, { "type": "SmallVariant", "id": "2696" }, { "type": "SmallVariant", "id": "2699" }, { "type": "SmallVariant", "id": "2719" }, { "type": "SmallVariant", "id": "2721" }, { "type": "SmallVariant", "id": "2725" }, { "type": "SmallVariant", "id": "2768" }, { "type": "SmallVariant", "id": "2829" }, { "type": "SmallVariant", "id": "2831" }, { "type": "SmallVariant", "id": "3175" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PROKR2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PROKR2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 52 }, "data": [ { "type": "GeneCombination", "id": "10" }, { "type": "GeneCombination", "id": "31" }, { "type": "GeneCombination", "id": "116" }, { "type": "GeneCombination", "id": "265" }, { "type": "GeneCombination", "id": "257" }, { "type": "GeneCombination", "id": "442" }, { "type": "GeneCombination", "id": "478" }, { "type": "GeneCombination", "id": "596" }, { "type": "GeneCombination", "id": "616" }, { "type": "GeneCombination", "id": "617" }, { "type": "GeneCombination", "id": "619" }, { "type": "GeneCombination", "id": "622" }, { "type": "GeneCombination", "id": "626" }, { "type": "GeneCombination", "id": "629" }, { "type": "GeneCombination", "id": "630" }, { "type": "GeneCombination", "id": "631" }, { "type": "GeneCombination", "id": "632" }, { "type": "GeneCombination", "id": "637" }, { "type": "GeneCombination", "id": "653" }, { "type": "GeneCombination", "id": "656" }, { "type": "GeneCombination", "id": "662" }, { "type": "GeneCombination", "id": "663" }, { "type": "GeneCombination", "id": "817" }, { "type": "GeneCombination", "id": "852" }, { "type": "GeneCombination", "id": "854" }, { "type": "GeneCombination", "id": "859" }, { "type": "GeneCombination", "id": "606" }, { "type": "GeneCombination", "id": "189" }, { "type": "GeneCombination", "id": "858" }, { "type": "GeneCombination", "id": "892" }, { "type": "GeneCombination", "id": "896" }, { "type": "GeneCombination", "id": "898" }, { "type": "GeneCombination", "id": "136" }, { "type": "GeneCombination", "id": "902" }, { "type": "GeneCombination", "id": "903" }, { "type": "GeneCombination", "id": "904" }, { "type": "GeneCombination", "id": "906" }, { "type": "GeneCombination", "id": "910" }, { "type": "GeneCombination", "id": "90" }, { "type": "GeneCombination", "id": "941" }, { "type": "GeneCombination", "id": "635" }, { "type": "GeneCombination", "id": "947" }, { "type": "GeneCombination", "id": "971" }, { "type": "GeneCombination", "id": "1061" }, { "type": "GeneCombination", "id": "1069" }, { "type": "GeneCombination", "id": "1080" }, { "type": "GeneCombination", "id": "1084" }, { "type": "GeneCombination", "id": "1088" }, { "type": "GeneCombination", "id": "1091" }, { "type": "GeneCombination", "id": "1092" }, { "type": "GeneCombination", "id": "1102" }, { "type": "GeneCombination", "id": "1111" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PROKR2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PROKR2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PROKR2/?format=api" } }, { "type": "Gene", "id": "SLC29A3", "attributes": { "go_molecular_function": [ "['nucleoside transmembrane transporter activity', 'protein binding']" ], "pathway_id": [ "kegg_path:hsa05034", "R-HSA-1643685", "R-HSA-382551", "R-HSA-425397", "R-HSA-425407", "R-HSA-5619063", "R-HSA-5619102", "R-HSA-5619115", "R-HSA-83936" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q9BZD2", "ensembl_id": "None", "entrez_id": "ENSG00000198246", "chromosome_number": "10", "lastmodified": "2023-05-16T12:02:33.525136" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "3169" }, { "type": "SmallVariant", "id": "3179" }, { "type": "SmallVariant", "id": "3281" }, { "type": "SmallVariant", "id": "3290" }, { "type": "SmallVariant", "id": "3326" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SLC29A3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SLC29A3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "1058" }, { "type": "GeneCombination", "id": "1061" }, { "type": "GeneCombination", "id": "1104" }, { "type": "GeneCombination", "id": "1107" }, { "type": "GeneCombination", "id": "1117" }, { "type": "GeneCombination", "id": "1121" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SLC29A3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SLC29A3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SLC29A3/?format=api" } }, { "type": "Gene", "id": "SOX8", "attributes": { "go_molecular_function": [ "['DNA binding', 'DNA-binding transcription factor binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'sequence-specific double-stranded DNA binding', 'DNA-binding transcription factor activity, RNA polymerase II-specific']" ], "pathway_id": [], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P57073", "ensembl_id": "None", "entrez_id": "ENSG00000005513", "chromosome_number": "16", "lastmodified": "2023-05-16T12:02:33.537424" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "3174" }, { "type": "SmallVariant", "id": "3306" }, { "type": "SmallVariant", "id": "3713" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SOX8/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SOX8/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "1061" }, { "type": "GeneCombination", "id": "1112" }, { "type": "GeneCombination", "id": "1256" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SOX8/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SOX8/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SOX8/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 7 } }