Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/245/genes/?format=api
{ "data": [ { "type": "Gene", "id": "HS6ST1", "attributes": { "go_molecular_function": [ "['heparan sulfate 6-O-sulfotransferase activity', 'protein binding', 'sulfotransferase activity']" ], "pathway_id": [ "kegg_path:hsa00534", "R-HSA-1430728", "R-HSA-1630316", "R-HSA-1638091", "R-HSA-2022928", "R-HSA-71387" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "O60243", "ensembl_id": "None", "entrez_id": "ENSG00000136720", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.274137" }, "relationships": { "variant_set": { "meta": { "count": 10 }, "data": [ { "type": "SmallVariant", "id": "783" }, { "type": "SmallVariant", "id": "807" }, { "type": "SmallVariant", "id": "853" }, { "type": "SmallVariant", "id": "1415" }, { "type": "SmallVariant", "id": "2498" }, { "type": "SmallVariant", "id": "2670" }, { "type": "SmallVariant", "id": "2779" }, { "type": "SmallVariant", "id": "2839" }, { "type": "SmallVariant", "id": "2969" }, { "type": "SmallVariant", "id": "3267" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HS6ST1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HS6ST1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 10 }, "data": [ { "type": "GeneCombination", "id": "245" }, { "type": "GeneCombination", "id": "252" }, { "type": "GeneCombination", "id": "444" }, { "type": "GeneCombination", "id": "847" }, { "type": "GeneCombination", "id": "889" }, { "type": "GeneCombination", "id": "929" }, { "type": "GeneCombination", "id": "944" }, { "type": "GeneCombination", "id": "263" }, { "type": "GeneCombination", "id": "989" }, { "type": "GeneCombination", "id": "1098" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HS6ST1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HS6ST1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/HS6ST1/?format=api" } }, { "type": "Gene", "id": "IL17RD", "attributes": { "go_molecular_function": [ "['interleukin-17 receptor activity']" ], "pathway_id": [ "R-HSA-162582", "R-HSA-5673001", "R-HSA-5674135", "R-HSA-5683057", "R-HSA-5684996" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q8NFM7", "ensembl_id": "None", "entrez_id": "ENSG00000144730", "chromosome_number": "3", "lastmodified": "2021-10-18T11:00:44.954610" }, "relationships": { "variant_set": { "meta": { "count": 18 }, "data": [ { "type": "SmallVariant", "id": "770" }, { "type": "SmallVariant", "id": "776" }, { "type": "SmallVariant", "id": "778" }, { "type": "SmallVariant", "id": "780" }, { "type": "SmallVariant", "id": "800" }, { "type": "SmallVariant", "id": "802" }, { "type": "SmallVariant", "id": "1831" }, { "type": "SmallVariant", "id": "1879" }, { "type": "SmallVariant", "id": "1897" }, { "type": "SmallVariant", "id": "2676" }, { "type": "SmallVariant", "id": "2780" }, { "type": "SmallVariant", "id": "2830" }, { "type": "SmallVariant", "id": "2833" }, { "type": "SmallVariant", "id": "2901" }, { "type": "SmallVariant", "id": "2977" }, { "type": "SmallVariant", "id": "3360" }, { "type": "SmallVariant", "id": "3382" }, { "type": "SmallVariant", "id": "3469" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/IL17RD/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/IL17RD/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 15 }, "data": [ { "type": "GeneCombination", "id": "242" }, { "type": "GeneCombination", "id": "245" }, { "type": "GeneCombination", "id": "251" }, { "type": "GeneCombination", "id": "625" }, { "type": "GeneCombination", "id": "671" }, { "type": "GeneCombination", "id": "891" }, { "type": "GeneCombination", "id": "929" }, { "type": "GeneCombination", "id": "635" }, { "type": "GeneCombination", "id": "942" }, { "type": "GeneCombination", "id": "243" }, { "type": "GeneCombination", "id": "962" }, { "type": "GeneCombination", "id": "993" }, { "type": "GeneCombination", "id": "244" }, { "type": "GeneCombination", "id": "1134" }, { "type": "GeneCombination", "id": "1164" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/IL17RD/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/IL17RD/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/IL17RD/?format=api" } }, { "type": "Gene", "id": "LEPR", "attributes": { "go_molecular_function": [ "['peptide hormone binding', 'cytokine binding', 'leptin receptor activity', 'transmembrane signaling receptor activity', 'protein binding', 'cytokine receptor activity']" ], "pathway_id": [ "kegg_path:hsa04060", "kegg_path:hsa04080", "kegg_path:hsa04152", "kegg_path:hsa04630", "kegg_path:hsa04920", "kegg_path:hsa04932" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P48357", "ensembl_id": "None", "entrez_id": "ENSG00000116678", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.635537" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "781" }, { "type": "SmallVariant", "id": "2885" }, { "type": "SmallVariant", "id": "2896" }, { "type": "SmallVariant", "id": "3004" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LEPR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LEPR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "245" }, { "type": "GeneCombination", "id": "955" }, { "type": "GeneCombination", "id": "960" }, { "type": "GeneCombination", "id": "1003" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LEPR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LEPR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/LEPR/?format=api" } }, { "type": "Gene", "id": "WDR11", "attributes": { "go_molecular_function": [ "['protein binding']" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "Q9BZH6", "ensembl_id": "None", "entrez_id": "ENSG00000120008", "chromosome_number": "10", "lastmodified": "2021-10-18T11:00:44.980173" }, "relationships": { "variant_set": { "meta": { "count": 16 }, "data": [ { "type": "SmallVariant", "id": "27" }, { "type": "SmallVariant", "id": "782" }, { "type": "SmallVariant", "id": "1309" }, { "type": "SmallVariant", "id": "1315" }, { "type": "SmallVariant", "id": "1869" }, { "type": "SmallVariant", "id": "1870" }, { "type": "SmallVariant", "id": "2407" }, { "type": "SmallVariant", "id": "2501" }, { "type": "SmallVariant", "id": "2503" }, { "type": "SmallVariant", "id": "2511" }, { "type": "SmallVariant", "id": "2665" }, { "type": "SmallVariant", "id": "2680" }, { "type": "SmallVariant", "id": "2729" }, { "type": "SmallVariant", "id": "2855" }, { "type": "SmallVariant", "id": "2936" }, { "type": "SmallVariant", "id": "3366" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/WDR11/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/WDR11/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 12 }, "data": [ { "type": "GeneCombination", "id": "10" }, { "type": "GeneCombination", "id": "245" }, { "type": "GeneCombination", "id": "410" }, { "type": "GeneCombination", "id": "411" }, { "type": "GeneCombination", "id": "621" }, { "type": "GeneCombination", "id": "851" }, { "type": "GeneCombination", "id": "820" }, { "type": "GeneCombination", "id": "886" }, { "type": "GeneCombination", "id": "892" }, { "type": "GeneCombination", "id": "908" }, { "type": "GeneCombination", "id": "976" }, { "type": "GeneCombination", "id": "848" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/WDR11/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/WDR11/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/WDR11/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }