Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/689/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ACADM", "attributes": { "go_molecular_function": [ "identical protein binding", "acyl-CoA dehydrogenase activity", "medium-chain-acyl-CoA dehydrogenase activity", "flavin adenine dinucleotide binding" ], "pathway_id": [ "kegg_path:hsa01212", "R-HSA-77286", "R-HSA-556833", "kegg_path:hsa00280", "kegg_path:hsa01100", "R-HSA-1989781", "R-HSA-400206", "R-HSA-77289", "kegg_path:hsa01212", "kegg_path:hsa00280", "R-HSA-1430728", "kegg_path:hsa03320", "R-HSA-77348", "kegg_path:hsa00071", "kegg_path:hsa00071", "R-HSA-8978868", "R-HSA-77288", "kegg_path:hsa01100", "kegg_path:hsa03320", "R-HSA-77346" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P11310", "ensembl_id": "ENSG00000117054", "entrez_id": "34", "chromosome_number": "1", "lastmodified": "2022-08-04T14:14:59.311666" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2000" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ACADM/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ACADM/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "689" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ACADM/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ACADM/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ACADM/?format=api" } }, { "type": "Gene", "id": "LIG4", "attributes": { "go_molecular_function": [ "protein binding", "protein C-terminus binding", "DNA binding", "DNA ligase activity", "metal ion binding", "DNA ligase (ATP) activity", "ATP binding", "ligase activity" ], "pathway_id": [ "R-HSA-73894", "kegg_path:hsa03450", "kegg_path:hsa03450", "R-HSA-5693532", "R-HSA-164843", "R-HSA-162906", "R-HSA-1643685", "R-HSA-5693571", "R-HSA-162587", "R-HSA-162594", "R-HSA-5663205", "R-HSA-162592" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P49917", "ensembl_id": "ENSG00000174405", "entrez_id": "3981", "chromosome_number": "13", "lastmodified": "2022-08-04T14:14:58.277319" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2001" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LIG4/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LIG4/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "689" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LIG4/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LIG4/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/LIG4/?format=api" } }, { "type": "Gene", "id": "ZFPM2", "attributes": { "go_molecular_function": [ "['zinc ion binding', 'transcription coactivator activity', 'DNA binding', 'RNA polymerase II-specific DNA-binding transcription factor binding', 'protein binding', 'transcription corepressor activity']" ], "pathway_id": [ "kegg_path:hsa05206", "R-HSA-109582", "R-HSA-1266738", "R-HSA-9690406", "R-HSA-983231" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q8WW38", "ensembl_id": "None", "entrez_id": "ENSG00000169946", "chromosome_number": "8", "lastmodified": "2021-10-18T11:00:44.324439" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "862" }, { "type": "SmallVariant", "id": "1213" }, { "type": "SmallVariant", "id": "1446" }, { "type": "SmallVariant", "id": "3216" }, { "type": "SmallVariant", "id": "3250" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ZFPM2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ZFPM2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "267" }, { "type": "GeneCombination", "id": "386" }, { "type": "GeneCombination", "id": "689" }, { "type": "GeneCombination", "id": "1075" }, { "type": "GeneCombination", "id": "1090" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ZFPM2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ZFPM2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ZFPM2/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }