Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/765/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ATG4C", "attributes": { "go_molecular_function": [ "cysteine-type peptidase activity", "protein binding", "cysteine-type endopeptidase activity" ], "pathway_id": [ "R-HSA-9612973", "R-HSA-1632852", "kegg_path:hsa04136", "kegg_path:hsa04140" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q96DT6", "ensembl_id": "ENSG00000125703", "entrez_id": "84938", "chromosome_number": "1", "lastmodified": "2022-08-04T14:15:00.000411" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "2275" }, { "type": "SmallVariant", "id": "2312" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ATG4C/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ATG4C/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "765" }, { "type": "GeneCombination", "id": "777" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ATG4C/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ATG4C/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ATG4C/?format=api" } }, { "type": "Gene", "id": "NOTCH4", "attributes": { "go_molecular_function": [ "calcium ion binding", "signaling receptor activity", "Notch binding", "protein binding" ], "pathway_id": [ "kegg_path:hsa04919", "R-HSA-9013694", "kegg_path:hsa05224", "R-HSA-5668914", "kegg_path:hsa01522", "R-HSA-73857", "kegg_path:hsa04919", "R-HSA-5668914", "R-HSA-162582", "R-HSA-1912408", "R-HSA-1912420", "R-HSA-9604323", "kegg_path:hsa04330", "kegg_path:hsa05200", "R-HSA-3781865", "kegg_path:hsa05206", "R-HSA-1912420", "kegg_path:hsa04330", "R-HSA-212436", "R-HSA-9604323", "R-HSA-1912408", "kegg_path:hsa05200", "R-HSA-162582", "R-HSA-9604323", "R-HSA-1912420", "kegg_path:hsa04330", "R-HSA-162582", "kegg_path:hsa05200", "kegg_path:hsa05165", "R-HSA-1912408", "kegg_path:hsa01522", "R-HSA-5668914", "R-HSA-9013694", "kegg_path:hsa04919", "R-HSA-9013694", "R-HSA-350054", "kegg_path:hsa01522", "kegg_path:hsa05206", "R-HSA-212436", "R-HSA-3781865", "kegg_path:hsa05165", "R-HSA-3781865", "R-HSA-1912420", "kegg_path:hsa05206", "kegg_path:hsa04919", "R-HSA-73857", "R-HSA-5668914", "kegg_path:hsa05224", "R-HSA-73857", "kegg_path:hsa05224", "R-HSA-350054", "R-HSA-1643685", "kegg_path:hsa01522", "R-HSA-9013695", "R-HSA-350054", "kegg_path:hsa05224", "R-HSA-9013694", "R-HSA-350054", "R-HSA-3906995", "R-HSA-73857", "kegg_path:hsa04330", "R-HSA-9604323", "R-HSA-212436", "R-HSA-1912399", "R-HSA-1912408", "kegg_path:hsa05165", "R-HSA-162582", "R-HSA-212436", "kegg_path:hsa05206", "R-HSA-74160", "R-HSA-3781865", "kegg_path:hsa05200", "kegg_path:hsa05165", "R-HSA-1643685", "R-HSA-9013695", "R-HSA-3906995", "R-HSA-1643685", "R-HSA-9013700", "R-HSA-1912399", "R-HSA-157118", "R-HSA-5083630", "R-HSA-1912422", "R-HSA-9013700", "R-HSA-1912422", "R-HSA-74160", "R-HSA-157118", "R-HSA-5083630", "R-HSA-74160", "R-HSA-1912422", "R-HSA-1912399", "R-HSA-9013700", "R-HSA-157118", "R-HSA-5083630", "R-HSA-74160", "R-HSA-1912399", "R-HSA-9013695", "R-HSA-3906995", "R-HSA-1643685", "R-HSA-9013695", "R-HSA-3906995", "R-HSA-9013700", "R-HSA-1912422", "R-HSA-157118", "R-HSA-5083630" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q99466", "ensembl_id": "ENSG00000204301", "entrez_id": "4855", "chromosome_number": "6", "lastmodified": "2022-08-04T14:15:00.008696" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2276" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NOTCH4/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NOTCH4/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "765" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NOTCH4/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NOTCH4/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NOTCH4/?format=api" } }, { "type": "Gene", "id": "RMI1", "attributes": { "go_molecular_function": [ "protein binding", "nucleotide binding" ], "pathway_id": [ "R-HSA-5693568", "R-HSA-6804756", "R-HSA-69473", "R-HSA-73894", "R-HSA-5685938", "R-HSA-5693532", "R-HSA-5693579", "R-HSA-5693538", "R-HSA-5693607", "R-HSA-73857", "R-HSA-5633007", "R-HSA-5693554", "R-HSA-1640170", "R-HSA-5693537", "R-HSA-212436", "R-HSA-3700989", "R-HSA-5685942", "R-HSA-69620", "R-HSA-69481", "R-HSA-5693567", "R-HSA-74160", "R-HSA-5693616", "kegg_path:hsa03460" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9H9A7", "ensembl_id": "ENSG00000178966", "entrez_id": "80010", "chromosome_number": "9", "lastmodified": "2022-08-04T14:14:59.533575" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2277" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RMI1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RMI1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "765" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RMI1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RMI1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/RMI1/?format=api" } }, { "type": "Gene", "id": "SAMD11", "attributes": { "go_molecular_function": [ "chromatin binding", "histone binding", "protein binding" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "Q96NU1", "ensembl_id": "ENSG00000187634", "entrez_id": "148398", "chromosome_number": "1", "lastmodified": "2022-08-04T14:14:59.520075" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "2266" }, { "type": "SmallVariant", "id": "2340" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SAMD11/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SAMD11/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "762" }, { "type": "GeneCombination", "id": "765" }, { "type": "GeneCombination", "id": "774" }, { "type": "GeneCombination", "id": "778" }, { "type": "GeneCombination", "id": "787" }, { "type": "GeneCombination", "id": "790" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SAMD11/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SAMD11/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SAMD11/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }