Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/409/genes/?format=api
{ "data": [ { "type": "Gene", "id": "BNC2", "attributes": { "go_molecular_function": [ "transcription cis-regulatory region binding", "DNA binding", "protein binding", "metal ion binding" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q6ZN30", "ensembl_id": "ENSG00000173068", "entrez_id": "54796", "chromosome_number": "9", "lastmodified": "2021-10-18T11:00:44.240289" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1288" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/BNC2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/BNC2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "409" }, { "type": "GeneCombination", "id": "410" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/BNC2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/BNC2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/BNC2/?format=api" } }, { "type": "Gene", "id": "FGF10", "attributes": { "go_molecular_function": [ "growth factor activity", "chemoattractant activity" ], "pathway_id": [ "R-HSA-5654738", "R-HSA-5655253", "R-HSA-6811558", "kegg_path:hsa04014", "R-HSA-5683057", "R-HSA-2428928", "R-HSA-5673001", "R-HSA-5654687", "R-HSA-1257604", "R-HSA-9006925", "R-HSA-186712", "R-HSA-5654700", "kegg_path:hsa05218", "kegg_path:hsa05224", "R-HSA-5654727", "kegg_path:hsa04810", "R-HSA-2219528", "R-HSA-1226099", "R-HSA-2428924", "R-HSA-5654695", "R-HSA-5654699", "R-HSA-2219530", "kegg_path:hsa04151", "R-HSA-1643685", "R-HSA-1839126", "R-HSA-190377", "R-HSA-2404192", "R-HSA-5654688", "R-HSA-190242", "R-HSA-109704", "R-HSA-5654693", "kegg_path:hsa05226", "R-HSA-112399", "R-HSA-74751", "R-HSA-1266738", "R-HSA-5654689", "R-HSA-5654696", "R-HSA-5654221", "R-HSA-5654736", "R-HSA-5663202", "kegg_path:hsa05200", "R-HSA-190370", "R-HSA-190241", "R-HSA-210747", "R-HSA-5654726", "kegg_path:hsa04010", "R-HSA-5654219", "R-HSA-5684996", "kegg_path:hsa04020", "R-HSA-74752", "R-HSA-162582", "R-HSA-190236", "R-HSA-9006934", "R-HSA-5658623", "kegg_path:hsa04015", "R-HSA-199418", "R-HSA-2033519" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "O15520", "ensembl_id": "ENSG00000070193", "entrez_id": "2255", "chromosome_number": "5", "lastmodified": "2021-10-18T11:00:44.580137" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1289" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FGF10/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FGF10/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "409" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FGF10/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FGF10/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FGF10/?format=api" } }, { "type": "Gene", "id": "HSD3B2", "attributes": { "go_molecular_function": [ "cholesterol dehydrogenase activity", "catalytic activity", "isomerase activity", "3-beta-hydroxy-delta5-steroid dehydrogenase activity", "steroid delta-isomerase activity", "oxidoreductase activity" ], "pathway_id": [ "kegg_path:hsa01100", "kegg_path:hsa01100", "kegg_path:hsa04934", "kegg_path:hsa04934", "R-HSA-1430728", "R-HSA-196071", "kegg_path:hsa04927", "kegg_path:hsa04927", "R-HSA-8957322", "R-HSA-193048", "R-HSA-194002", "kegg_path:hsa04913", "kegg_path:hsa04913", "kegg_path:hsa04925", "kegg_path:hsa04925", "kegg_path:hsa00140", "kegg_path:hsa00140", "R-HSA-193993", "R-HSA-556833" ], "essential_gene": null, "status": "CU", "uniprot_acc": "P26439", "ensembl_id": "ENSG00000203859", "entrez_id": "3284", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.981233" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "582" }, { "type": "SmallVariant", "id": "1290" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HSD3B2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HSD3B2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "201" }, { "type": "GeneCombination", "id": "409" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HSD3B2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HSD3B2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/HSD3B2/?format=api" } }, { "type": "Gene", "id": "IRX5", "attributes": { "go_molecular_function": [ "vitamin D binding", "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "sequence-specific double-stranded DNA binding", "DNA-binding transcription factor activity, RNA polymerase II-specific", "DNA binding" ], "pathway_id": [], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P78411", "ensembl_id": "ENSG00000176842", "entrez_id": "10265", "chromosome_number": "16", "lastmodified": "2021-10-18T11:00:44.786497" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1291" }, { "type": "SmallVariant", "id": "1302" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/IRX5/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/IRX5/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "409" }, { "type": "GeneCombination", "id": "410" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/IRX5/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/IRX5/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/IRX5/?format=api" } }, { "type": "Gene", "id": "MAML2", "attributes": { "go_molecular_function": [ "transcription coactivator activity" ], "pathway_id": [ "kegg_path:hsa04658", "R-HSA-2197563", "kegg_path:hsa05165", "R-HSA-1266738", "R-HSA-212436", "R-HSA-9013694", "R-HSA-2122947", "R-HSA-9013695", "R-HSA-1980145", "R-HSA-350054", "R-HSA-5663202", "R-HSA-74160", "R-HSA-9013508", "kegg_path:hsa04330", "R-HSA-8878159", "R-HSA-162582", "R-HSA-1980143", "R-HSA-1912408", "R-HSA-210744", "R-HSA-2644603", "R-HSA-2894858", "R-HSA-186712", "R-HSA-73857", "R-HSA-157118", "R-HSA-1912422", "R-HSA-2894862", "R-HSA-9012852", "R-HSA-8941856", "R-HSA-1643685", "R-HSA-2644602", "R-HSA-2644606" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q8IZL2", "ensembl_id": "ENSG00000184384", "entrez_id": "84441", "chromosome_number": "11", "lastmodified": "2021-10-18T11:00:44.549023" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "760" }, { "type": "SmallVariant", "id": "1292" }, { "type": "SmallVariant", "id": "1322" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAML2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAML2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "240" }, { "type": "GeneCombination", "id": "409" }, { "type": "GeneCombination", "id": "412" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAML2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAML2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MAML2/?format=api" } }, { "type": "Gene", "id": "MAMLD1", "attributes": { "go_molecular_function": [ "['molecular_function']" ], "pathway_id": [ "R-HSA-1266738", "R-HSA-157118", "R-HSA-162582", "R-HSA-1643685", "R-HSA-186712", "R-HSA-1912408", "R-HSA-1912422", "R-HSA-1980143", "R-HSA-1980145", "R-HSA-210744", "R-HSA-2122947", "R-HSA-212436", "R-HSA-2197563", "R-HSA-2644602", "R-HSA-2644603", "R-HSA-2644606", "R-HSA-2894858", "R-HSA-2894862", "R-HSA-350054", "R-HSA-5663202", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878159", "R-HSA-8941856", "R-HSA-9012852", "R-HSA-9013508", "R-HSA-9013694", "R-HSA-9013695", "R-HSA-1266738", "R-HSA-157118", "R-HSA-162582", "R-HSA-1643685", "R-HSA-186712", "R-HSA-1912408", "R-HSA-1912422", "R-HSA-1980143", "R-HSA-1980145", "R-HSA-210744", "R-HSA-2122947", "R-HSA-212436", "R-HSA-2197563", "R-HSA-2644602", "R-HSA-2644603", "R-HSA-2644606", "R-HSA-2894858", "R-HSA-2894862", "R-HSA-350054", "R-HSA-5663202", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878159", "R-HSA-8941856", "R-HSA-9012852", "R-HSA-9013508", "R-HSA-9013694", "R-HSA-9013695" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q13495", "ensembl_id": "None", "entrez_id": "ENSG00000013619", "chromosome_number": "X", "lastmodified": "2021-10-18T11:00:44.997839" }, "relationships": { "variant_set": { "meta": { "count": 22 }, "data": [ { "type": "SmallVariant", "id": "581" }, { "type": "SmallVariant", "id": "717" }, { "type": "SmallVariant", "id": "722" }, { "type": "SmallVariant", "id": "729" }, { "type": "SmallVariant", "id": "733" }, { "type": "SmallVariant", "id": "736" }, { "type": "SmallVariant", "id": "742" }, { "type": "SmallVariant", "id": "745" }, { "type": "SmallVariant", "id": "752" }, { "type": "SmallVariant", "id": "757" }, { "type": "SmallVariant", "id": "1268" }, { "type": "SmallVariant", "id": "1278" }, { "type": "SmallVariant", "id": "1280" }, { "type": "SmallVariant", "id": "1283" }, { "type": "SmallVariant", "id": "1294" }, { "type": "SmallVariant", "id": "1310" }, { "type": "SmallVariant", "id": "1316" }, { "type": "SmallVariant", "id": "3192" }, { "type": "SmallVariant", "id": "3200" }, { "type": "SmallVariant", "id": "3252" }, { "type": "SmallVariant", "id": "3259" }, { "type": "SmallVariant", "id": "3325" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAMLD1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAMLD1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 26 }, "data": [ { "type": "GeneCombination", "id": "236" }, { "type": "GeneCombination", "id": "240" }, { "type": "GeneCombination", "id": "200" }, { "type": "GeneCombination", "id": "237" }, { "type": "GeneCombination", "id": "238" }, { "type": "GeneCombination", "id": "231" }, { "type": "GeneCombination", "id": "232" }, { "type": "GeneCombination", "id": "233" }, { "type": "GeneCombination", "id": "234" }, { "type": "GeneCombination", "id": "235" }, { "type": "GeneCombination", "id": "239" }, { "type": "GeneCombination", "id": "406" }, { "type": "GeneCombination", "id": "407" }, { "type": "GeneCombination", "id": "408" }, { "type": "GeneCombination", "id": "405" }, { "type": "GeneCombination", "id": "409" }, { "type": "GeneCombination", "id": "410" }, { "type": "GeneCombination", "id": "411" }, { "type": "GeneCombination", "id": "412" }, { "type": "GeneCombination", "id": "1067" }, { "type": "GeneCombination", "id": "1068" }, { "type": "GeneCombination", "id": "1091" }, { "type": "GeneCombination", "id": "1092" }, { "type": "GeneCombination", "id": "1095" }, { "type": "GeneCombination", "id": "1120" }, { "type": "GeneCombination", "id": "1122" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAMLD1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAMLD1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MAMLD1/?format=api" } }, { "type": "Gene", "id": "NOTCH2", "attributes": { "go_molecular_function": [ "calcium ion binding", "protein binding", "enzyme binding", "NF-kappaB binding", "signaling receptor activity" ], "pathway_id": [ "R-HSA-1912399", "R-HSA-1912408", "R-HSA-162582", "kegg_path:hsa04330", "kegg_path:hsa04919", "kegg_path:hsa05200", "kegg_path:hsa05206", "R-HSA-350054", "R-HSA-74160", "R-HSA-1980145", "kegg_path:hsa05224", "kegg_path:hsa01522", "R-HSA-9013695", "R-HSA-212436", "R-HSA-9013694", "kegg_path:hsa05165", "R-HSA-3906995", "kegg_path:hsa04658", "R-HSA-2197563", "R-HSA-5668914", "kegg_path:hsa04919", "kegg_path:hsa04330", "R-HSA-3781865", "kegg_path:hsa05206", "R-HSA-1643685", "kegg_path:hsa05200", "R-HSA-2979096", "kegg_path:hsa05224", "R-HSA-1912422", "kegg_path:hsa01522", "kegg_path:hsa05165", "R-HSA-157118", "R-HSA-1912420", "R-HSA-5083630", "R-HSA-73857", "kegg_path:hsa04658" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q04721", "ensembl_id": "ENSG00000134250", "entrez_id": "4853", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.464507" }, "relationships": { "variant_set": { "meta": { "count": 6 }, "data": [ { "type": "SmallVariant", "id": "501" }, { "type": "SmallVariant", "id": "724" }, { "type": "SmallVariant", "id": "762" }, { "type": "SmallVariant", "id": "1293" }, { "type": "SmallVariant", "id": "1313" }, { "type": "SmallVariant", "id": "2305" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NOTCH2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NOTCH2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 7 }, "data": [ { "type": "GeneCombination", "id": "240" }, { "type": "GeneCombination", "id": "167" }, { "type": "GeneCombination", "id": "232" }, { "type": "GeneCombination", "id": "235" }, { "type": "GeneCombination", "id": "409" }, { "type": "GeneCombination", "id": "411" }, { "type": "GeneCombination", "id": "774" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NOTCH2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NOTCH2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NOTCH2/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 7 } }