Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/453/genes/?format=api
{ "data": [ { "type": "Gene", "id": "FIG4", "attributes": { "go_molecular_function": [ "['phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity', 'protein serine/threonine phosphatase activity', 'phosphatidylinositol-4-phosphate phosphatase activity', 'phosphatidylinositol-3-phosphatase activity', 'protein binding', 'phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity', 'phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity']" ], "pathway_id": [ "kegg_path:hsa00562", "kegg_path:hsa01100", "kegg_path:hsa05014", "kegg_path:hsa05022", "R-HSA-1430728", "R-HSA-1483255", "R-HSA-1483257", "R-HSA-1660514", "R-HSA-1660516", "R-HSA-1660517", "R-HSA-556833" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q92562", "ensembl_id": "None", "entrez_id": "ENSG00000112367", "chromosome_number": "6", "lastmodified": "2021-10-18T11:00:44.947126" }, "relationships": { "variant_set": { "meta": { "count": 11 }, "data": [ { "type": "SmallVariant", "id": "549" }, { "type": "SmallVariant", "id": "941" }, { "type": "SmallVariant", "id": "1426" }, { "type": "SmallVariant", "id": "1433" }, { "type": "SmallVariant", "id": "1438" }, { "type": "SmallVariant", "id": "2053" }, { "type": "SmallVariant", "id": "2055" }, { "type": "SmallVariant", "id": "2089" }, { "type": "SmallVariant", "id": "2197" }, { "type": "SmallVariant", "id": "3431" }, { "type": "SmallVariant", "id": "3439" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FIG4/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FIG4/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 8 }, "data": [ { "type": "GeneCombination", "id": "187" }, { "type": "GeneCombination", "id": "300" }, { "type": "GeneCombination", "id": "449" }, { "type": "GeneCombination", "id": "453" }, { "type": "GeneCombination", "id": "456" }, { "type": "GeneCombination", "id": "708" }, { "type": "GeneCombination", "id": "723" }, { "type": "GeneCombination", "id": "1154" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FIG4/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FIG4/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FIG4/?format=api" } }, { "type": "Gene", "id": "FUS", "attributes": { "go_molecular_function": [ "['DNA binding', 'chromatin binding', \"mRNA 3'-UTR binding\", 'transcription coregulator activity', 'protein binding', 'RNA binding', 'transcription coactivator activity', 'metal ion binding', 'identical protein binding']" ], "pathway_id": [ "kegg_path:hsa03013", "kegg_path:hsa03015", "kegg_path:hsa03040", "kegg_path:hsa05014", "kegg_path:hsa05022", "kegg_path:hsa05202", "R-HSA-72163", "R-HSA-72172", "R-HSA-72203", "R-HSA-8953854", "kegg_path:hsa03013", "kegg_path:hsa03015", "kegg_path:hsa03040", "kegg_path:hsa05014", "kegg_path:hsa05022", "kegg_path:hsa05202" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P35637", "ensembl_id": "None", "entrez_id": "ENSG00000089280", "chromosome_number": "16", "lastmodified": "2021-10-18T11:00:44.299468" }, "relationships": { "variant_set": { "meta": { "count": 13 }, "data": [ { "type": "SmallVariant", "id": "536" }, { "type": "SmallVariant", "id": "539" }, { "type": "SmallVariant", "id": "1373" }, { "type": "SmallVariant", "id": "1374" }, { "type": "SmallVariant", "id": "1389" }, { "type": "SmallVariant", "id": "1391" }, { "type": "SmallVariant", "id": "1432" }, { "type": "SmallVariant", "id": "1708" }, { "type": "SmallVariant", "id": "1711" }, { "type": "SmallVariant", "id": "1806" }, { "type": "SmallVariant", "id": "2101" }, { "type": "SmallVariant", "id": "3436" }, { "type": "SmallVariant", "id": "3606" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FUS/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FUS/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 11 }, "data": [ { "type": "GeneCombination", "id": "180" }, { "type": "GeneCombination", "id": "182" }, { "type": "GeneCombination", "id": "431" }, { "type": "GeneCombination", "id": "432" }, { "type": "GeneCombination", "id": "438" }, { "type": "GeneCombination", "id": "453" }, { "type": "GeneCombination", "id": "559" }, { "type": "GeneCombination", "id": "560" }, { "type": "GeneCombination", "id": "727" }, { "type": "GeneCombination", "id": "913" }, { "type": "GeneCombination", "id": "914" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FUS/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FUS/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FUS/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2024 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 2 } }