Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/283/genes/?format=api
{ "data": [ { "type": "Gene", "id": "NOS1", "attributes": { "go_molecular_function": [ "calcium-dependent protein binding", "FMN binding", "nitric-oxide synthase activity", "flavin adenine dinucleotide binding", "calmodulin binding", "oxidoreductase activity" ], "pathway_id": [ "kegg_path:hsa01100", "kegg_path:hsa04730", "kegg_path:hsa00330", "kegg_path:hsa04713", "kegg_path:hsa04970", "R-HSA-5578775", "kegg_path:hsa00220", "kegg_path:hsa04926", "kegg_path:hsa05014", "kegg_path:hsa04713", "kegg_path:hsa04970", "kegg_path:hsa00330", "kegg_path:hsa01100", "kegg_path:hsa04730", "kegg_path:hsa00220", "kegg_path:hsa05022", "kegg_path:hsa04371", "kegg_path:hsa04145", "kegg_path:hsa05010", "kegg_path:hsa04926", "kegg_path:hsa05014", "R-HSA-109582", "R-HSA-397014", "R-HSA-1222556", "kegg_path:hsa04020", "kegg_path:hsa01100", "kegg_path:hsa04730", "R-HSA-168249", "kegg_path:hsa04020", "kegg_path:hsa00330", "kegg_path:hsa04713", "kegg_path:hsa04970", "kegg_path:hsa04926", "kegg_path:hsa05014", "R-HSA-168256", "kegg_path:hsa04371", "kegg_path:hsa05022", "kegg_path:hsa00220", "R-HSA-5576891", "kegg_path:hsa05010", "kegg_path:hsa04145", "kegg_path:hsa04371", "R-HSA-392154", "R-HSA-418346", "kegg_path:hsa05022", "kegg_path:hsa04145", "kegg_path:hsa05010", "kegg_path:hsa04020" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P29475", "ensembl_id": "ENSG00000089250", "entrez_id": "4842", "chromosome_number": "12", "lastmodified": "2021-10-18T11:00:44.332724" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "907" }, { "type": "SmallVariant", "id": "1666" }, { "type": "SmallVariant", "id": "1866" }, { "type": "SmallVariant", "id": "1925" }, { "type": "SmallVariant", "id": "1947" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NOS1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NOS1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "283" }, { "type": "GeneCombination", "id": "542" }, { "type": "GeneCombination", "id": "620" }, { "type": "GeneCombination", "id": "650" }, { "type": "GeneCombination", "id": "660" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NOS1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NOS1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NOS1/?format=api" } }, { "type": "Gene", "id": "RD3", "attributes": { "go_molecular_function": [ "protein binding" ], "pathway_id": [], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q7Z3Z2", "ensembl_id": "ENSG00000198570", "entrez_id": "343035", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.876385" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "908" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RD3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RD3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "283" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RD3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RD3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/RD3/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 2 } }