Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1210/genes/?format=api
{ "data": [ { "type": "Gene", "id": "AGTR2", "attributes": { "go_molecular_function": [ "['receptor antagonist activity', 'G protein-coupled receptor activity', 'angiotensin type II receptor activity', 'protein binding']" ], "pathway_id": [ "kegg_path:hsa04080", "kegg_path:hsa04261", "kegg_path:hsa04614", "R-HSA-162582", "R-HSA-372790", "R-HSA-373076", "R-HSA-375276", "R-HSA-388396", "R-HSA-418594", "R-HSA-500792", "kegg_path:hsa04080", "kegg_path:hsa04261", "kegg_path:hsa04614", "R-HSA-162582", "R-HSA-372790", "R-HSA-373076", "R-HSA-375276", "R-HSA-388396", "R-HSA-418594", "R-HSA-500792" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P50052", "ensembl_id": "None", "entrez_id": "ENSG00000180772", "chromosome_number": "X", "lastmodified": "2024-02-29T15:02:20.674670" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3596" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AGTR2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AGTR2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "1210" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AGTR2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AGTR2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/AGTR2/?format=api" } }, { "type": "Gene", "id": "CSMD1", "attributes": { "go_molecular_function": [ "['protein binding']" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "F5GZ18", "ensembl_id": "None", "entrez_id": "ENSG00000183117", "chromosome_number": "8", "lastmodified": "2024-02-29T15:02:20.667185" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3594" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CSMD1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CSMD1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "1210" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CSMD1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CSMD1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CSMD1/?format=api" } }, { "type": "Gene", "id": "LAMA2", "attributes": { "go_molecular_function": [ "['structural molecule activity', 'signaling receptor binding', 'extracellular matrix structural constituent']" ], "pathway_id": [ "kegg_path:hsa04151", "kegg_path:hsa04510", "kegg_path:hsa04512", "kegg_path:hsa05145", "kegg_path:hsa05146", "kegg_path:hsa05165", "kegg_path:hsa05200", "kegg_path:hsa05222", "kegg_path:hsa05410", "kegg_path:hsa05412", "kegg_path:hsa05414", "kegg_path:hsa05416", "R-HSA-1266738", "R-HSA-1474244", "R-HSA-162582", "R-HSA-3000157", "R-HSA-3000171", "R-HSA-3000178", "R-HSA-6806834", "R-HSA-8874081", "R-HSA-8875878", "R-HSA-9006934", "R-HSA-9619665", "R-HSA-9675108" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P24043", "ensembl_id": "None", "entrez_id": "ENSG00000196569", "chromosome_number": "6", "lastmodified": "2022-08-04T14:14:57.609595" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "2128" }, { "type": "SmallVariant", "id": "3593" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LAMA2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LAMA2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "733" }, { "type": "GeneCombination", "id": "1210" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LAMA2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LAMA2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/LAMA2/?format=api" } }, { "type": "Gene", "id": "TLR4", "attributes": { "go_molecular_function": [ "['signaling receptor activity', 'signaling receptor binding', 'identical protein binding', 'transmembrane signaling receptor activity', 'protein heterodimerization activity', 'protein binding', 'NAD+ nucleotidase, cyclic ADP-ribose generating', 'amyloid-beta binding', 'lipopolysaccharide binding', 'lipopolysaccharide immune receptor activity', 'NAD(P)+ nucleosidase activity']" ], "pathway_id": [ "kegg_path:hsa04064", "kegg_path:hsa04066", "kegg_path:hsa04145", "kegg_path:hsa04151", "kegg_path:hsa04217", "kegg_path:hsa04613", "kegg_path:hsa04620", "kegg_path:hsa04621", "kegg_path:hsa05130", "kegg_path:hsa05131", "kegg_path:hsa05132", "kegg_path:hsa05133", "kegg_path:hsa05134", "kegg_path:hsa05135", "kegg_path:hsa05140", "kegg_path:hsa05142", "kegg_path:hsa05144", "kegg_path:hsa05145", "kegg_path:hsa05146", "kegg_path:hsa05152", "kegg_path:hsa05161", "kegg_path:hsa05162", "kegg_path:hsa05164", "kegg_path:hsa05170", "kegg_path:hsa05171", "kegg_path:hsa05205", "kegg_path:hsa05235", "kegg_path:hsa05321", "kegg_path:hsa05323", "R-HSA-109581", "R-HSA-1236974", "R-HSA-1236975", "R-HSA-1280218", "R-HSA-140534", "R-HSA-1643685", "R-HSA-166016", "R-HSA-166058", "R-HSA-166166", "R-HSA-168138", "R-HSA-168179", "R-HSA-168181", "R-HSA-168188", "R-HSA-168249", "R-HSA-168256", "R-HSA-168898", "R-HSA-181438", "R-HSA-2562578", "R-HSA-5260271", "R-HSA-5357769", "R-HSA-5357801", "R-HSA-5602358", "R-HSA-5602498", "R-HSA-5603041", "R-HSA-5686938", "R-HSA-936964", "R-HSA-937041", "R-HSA-937061", "R-HSA-937072", "R-HSA-975138", "R-HSA-975155", "R-HSA-975163", "R-HSA-983169" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "O00206", "ensembl_id": "None", "entrez_id": "ENSG00000136869", "chromosome_number": "9", "lastmodified": "2024-02-29T15:02:20.671057" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3595" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TLR4/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TLR4/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "1210" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TLR4/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TLR4/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/TLR4/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }