Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/913/genes/?format=api
{ "data": [ { "type": "Gene", "id": "DNAH10", "attributes": { "go_molecular_function": [ "['minus-end-directed microtubule motor activity', 'dynein light intermediate chain binding', 'dynein intermediate chain binding', 'ATP binding']" ], "pathway_id": [ "kegg_path:hsa05014", "kegg_path:hsa05016", "kegg_path:hsa05022" ], "essential_gene": null, "status": "CU", "uniprot_acc": "A0A1C7CYW8", "ensembl_id": "None", "entrez_id": "ENSG00000197653", "chromosome_number": "12", "lastmodified": "2023-05-16T12:02:32.702603" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "2744" }, { "type": "SmallVariant", "id": "2745" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/DNAH10/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/DNAH10/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "913" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/DNAH10/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/DNAH10/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/DNAH10/?format=api" } }, { "type": "Gene", "id": "FUS", "attributes": { "go_molecular_function": [ "['DNA binding', 'chromatin binding', \"mRNA 3'-UTR binding\", 'transcription coregulator activity', 'protein binding', 'RNA binding', 'transcription coactivator activity', 'metal ion binding', 'identical protein binding']" ], "pathway_id": [ "kegg_path:hsa03013", "kegg_path:hsa03015", "kegg_path:hsa03040", "kegg_path:hsa05014", "kegg_path:hsa05022", "kegg_path:hsa05202", "R-HSA-72163", "R-HSA-72172", "R-HSA-72203", "R-HSA-8953854", "kegg_path:hsa03013", "kegg_path:hsa03015", "kegg_path:hsa03040", "kegg_path:hsa05014", "kegg_path:hsa05022", "kegg_path:hsa05202" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P35637", "ensembl_id": "None", "entrez_id": "ENSG00000089280", "chromosome_number": "16", "lastmodified": "2021-10-18T11:00:44.299468" }, "relationships": { "variant_set": { "meta": { "count": 13 }, "data": [ { "type": "SmallVariant", "id": "536" }, { "type": "SmallVariant", "id": "539" }, { "type": "SmallVariant", "id": "1373" }, { "type": "SmallVariant", "id": "1374" }, { "type": "SmallVariant", "id": "1389" }, { "type": "SmallVariant", "id": "1391" }, { "type": "SmallVariant", "id": "1432" }, { "type": "SmallVariant", "id": "1708" }, { "type": "SmallVariant", "id": "1711" }, { "type": "SmallVariant", "id": "1806" }, { "type": "SmallVariant", "id": "2101" }, { "type": "SmallVariant", "id": "3436" }, { "type": "SmallVariant", "id": "3606" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FUS/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FUS/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 11 }, "data": [ { "type": "GeneCombination", "id": "180" }, { "type": "GeneCombination", "id": "182" }, { "type": "GeneCombination", "id": "431" }, { "type": "GeneCombination", "id": "432" }, { "type": "GeneCombination", "id": "438" }, { "type": "GeneCombination", "id": "453" }, { "type": "GeneCombination", "id": "559" }, { "type": "GeneCombination", "id": "560" }, { "type": "GeneCombination", "id": "727" }, { "type": "GeneCombination", "id": "913" }, { "type": "GeneCombination", "id": "914" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FUS/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FUS/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FUS/?format=api" } }, { "type": "Gene", "id": "MROH2A", "attributes": { "go_molecular_function": [], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "A6NES4", "ensembl_id": "None", "entrez_id": "ENSG00000185038", "chromosome_number": "2", "lastmodified": "2023-05-16T12:02:32.687861" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "2738" }, { "type": "SmallVariant", "id": "2739" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MROH2A/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MROH2A/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "913" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MROH2A/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MROH2A/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MROH2A/?format=api" } }, { "type": "Gene", "id": "SCUBE2", "attributes": { "go_molecular_function": [ "['lipid binding', 'calcium ion binding', 'protein binding']" ], "pathway_id": [ "R-HSA-162582", "R-HSA-5358346", "R-HSA-5358351", "R-HSA-5362798" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q9NQ36", "ensembl_id": "None", "entrez_id": "ENSG00000175356", "chromosome_number": "11", "lastmodified": "2021-10-18T11:00:44.941425" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "1473" }, { "type": "SmallVariant", "id": "1477" }, { "type": "SmallVariant", "id": "1839" }, { "type": "SmallVariant", "id": "2742" }, { "type": "SmallVariant", "id": "2743" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SCUBE2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SCUBE2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "471" }, { "type": "GeneCombination", "id": "472" }, { "type": "GeneCombination", "id": "609" }, { "type": "GeneCombination", "id": "913" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SCUBE2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SCUBE2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SCUBE2/?format=api" } }, { "type": "Gene", "id": "TRIM42", "attributes": { "go_molecular_function": [ "['zinc ion binding', 'protein binding']" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "Q8IWZ5", "ensembl_id": "None", "entrez_id": "ENSG00000155890", "chromosome_number": "3", "lastmodified": "2023-05-16T12:02:32.692509" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "2740" }, { "type": "SmallVariant", "id": "2741" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TRIM42/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TRIM42/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "913" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TRIM42/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TRIM42/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/TRIM42/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 5 } }