Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1128/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ERBB4", "attributes": { "go_molecular_function": [ "['epidermal growth factor receptor binding', 'protein tyrosine kinase activity', 'protein homodimerization activity', 'transmembrane receptor protein tyrosine kinase activity', 'protein serine/threonine/tyrosine kinase activity', 'transcription cis-regulatory region binding', 'protein binding', 'ATP binding']" ], "pathway_id": [ "kegg_path:hsa04010", "kegg_path:hsa04012", "kegg_path:hsa04020", "kegg_path:hsa04151", "kegg_path:hsa05014", "kegg_path:hsa05205" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q15303", "ensembl_id": "None", "entrez_id": "ENSG00000178568", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.341456" }, "relationships": { "variant_set": { "meta": { "count": 6 }, "data": [ { "type": "SmallVariant", "id": "1896" }, { "type": "SmallVariant", "id": "2072" }, { "type": "SmallVariant", "id": "2262" }, { "type": "SmallVariant", "id": "2263" }, { "type": "SmallVariant", "id": "3353" }, { "type": "SmallVariant", "id": "3447" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ERBB4/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ERBB4/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 8 }, "data": [ { "type": "GeneCombination", "id": "634" }, { "type": "GeneCombination", "id": "648" }, { "type": "GeneCombination", "id": "668" }, { "type": "GeneCombination", "id": "670" }, { "type": "GeneCombination", "id": "716" }, { "type": "GeneCombination", "id": "762" }, { "type": "GeneCombination", "id": "1128" }, { "type": "GeneCombination", "id": "1158" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ERBB4/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ERBB4/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ERBB4/?format=api" } }, { "type": "Gene", "id": "NEK1", "attributes": { "go_molecular_function": [ "['protein tyrosine kinase activity', 'protein serine kinase activity', 'protein serine/threonine/tyrosine kinase activity', 'protein binding', 'protein kinase activity', 'protein serine/threonine kinase activity', '14-3-3 protein binding', 'metal ion binding', 'kinase activity', 'ATP binding']" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q96PY6", "ensembl_id": "None", "entrez_id": "ENSG00000137601", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:44.841783" }, "relationships": { "variant_set": { "meta": { "count": 22 }, "data": [ { "type": "SmallVariant", "id": "976" }, { "type": "SmallVariant", "id": "1369" }, { "type": "SmallVariant", "id": "1814" }, { "type": "SmallVariant", "id": "2052" }, { "type": "SmallVariant", "id": "2056" }, { "type": "SmallVariant", "id": "2062" }, { "type": "SmallVariant", "id": "2085" }, { "type": "SmallVariant", "id": "2096" }, { "type": "SmallVariant", "id": "2132" }, { "type": "SmallVariant", "id": "2138" }, { "type": "SmallVariant", "id": "2188" }, { "type": "SmallVariant", "id": "2190" }, { "type": "SmallVariant", "id": "2191" }, { "type": "SmallVariant", "id": "2193" }, { "type": "SmallVariant", "id": "2194" }, { "type": "SmallVariant", "id": "2196" }, { "type": "SmallVariant", "id": "2198" }, { "type": "SmallVariant", "id": "3352" }, { "type": "SmallVariant", "id": "3414" }, { "type": "SmallVariant", "id": "3425" }, { "type": "SmallVariant", "id": "3427" }, { "type": "SmallVariant", "id": "3430" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NEK1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NEK1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 18 }, "data": [ { "type": "GeneCombination", "id": "748" }, { "type": "GeneCombination", "id": "749" }, { "type": "GeneCombination", "id": "313" }, { "type": "GeneCombination", "id": "428" }, { "type": "GeneCombination", "id": "599" }, { "type": "GeneCombination", "id": "600" }, { "type": "GeneCombination", "id": "707" }, { "type": "GeneCombination", "id": "708" }, { "type": "GeneCombination", "id": "711" }, { "type": "GeneCombination", "id": "727" }, { "type": "GeneCombination", "id": "726" }, { "type": "GeneCombination", "id": "725" }, { "type": "GeneCombination", "id": "721" }, { "type": "GeneCombination", "id": "734" }, { "type": "GeneCombination", "id": "747" }, { "type": "GeneCombination", "id": "735" }, { "type": "GeneCombination", "id": "1128" }, { "type": "GeneCombination", "id": "1145" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NEK1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NEK1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NEK1/?format=api" } }, { "type": "Gene", "id": "TARDBP", "attributes": { "go_molecular_function": [ "['RNA polymerase II cis-regulatory region sequence-specific DNA binding', \"mRNA 3'-UTR binding\", 'pre-mRNA intronic binding', 'double-stranded DNA binding', 'protein binding', 'RNA binding', 'identical protein binding']" ], "pathway_id": [ "kegg_path:hsa03013", "kegg_path:hsa03015", "kegg_path:hsa05014", "kegg_path:hsa05022", "kegg_path:hsa03013", "kegg_path:hsa03015", "kegg_path:hsa05014", "kegg_path:hsa05022", "kegg_path:hsa03013", "kegg_path:hsa03015", "kegg_path:hsa05014", "kegg_path:hsa05022" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q13148", "ensembl_id": "None", "entrez_id": "ENSG00000120948", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.778821" }, "relationships": { "variant_set": { "meta": { "count": 12 }, "data": [ { "type": "SmallVariant", "id": "540" }, { "type": "SmallVariant", "id": "871" }, { "type": "SmallVariant", "id": "932" }, { "type": "SmallVariant", "id": "1430" }, { "type": "SmallVariant", "id": "1695" }, { "type": "SmallVariant", "id": "1704" }, { "type": "SmallVariant", "id": "2750" }, { "type": "SmallVariant", "id": "3060" }, { "type": "SmallVariant", "id": "3416" }, { "type": "SmallVariant", "id": "3440" }, { "type": "SmallVariant", "id": "3444" }, { "type": "SmallVariant", "id": "3607" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TARDBP/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TARDBP/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 13 }, "data": [ { "type": "GeneCombination", "id": "183" }, { "type": "GeneCombination", "id": "271" }, { "type": "GeneCombination", "id": "295" }, { "type": "GeneCombination", "id": "452" }, { "type": "GeneCombination", "id": "916" }, { "type": "GeneCombination", "id": "917" }, { "type": "GeneCombination", "id": "919" }, { "type": "GeneCombination", "id": "553" }, { "type": "GeneCombination", "id": "1027" }, { "type": "GeneCombination", "id": "1128" }, { "type": "GeneCombination", "id": "1146" }, { "type": "GeneCombination", "id": "1155" }, { "type": "GeneCombination", "id": "1157" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TARDBP/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TARDBP/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/TARDBP/?format=api" } }, { "type": "Gene", "id": "VEGFA", "attributes": { "go_molecular_function": [ "['vascular endothelial growth factor receptor 2 binding', 'extracellular matrix binding', 'fibronectin binding', 'protein homodimerization activity', 'growth factor activity', 'vascular endothelial growth factor receptor 1 binding', 'vascular endothelial growth factor receptor binding', 'protein binding', 'platelet-derived growth factor receptor binding', 'heparin binding', 'receptor ligand activity', 'chemoattractant activity', 'identical protein binding', 'cytokine activity']" ], "pathway_id": [ "kegg_path:hsa01521", "kegg_path:hsa04010", "kegg_path:hsa04014", "kegg_path:hsa04015", "kegg_path:hsa04020", "kegg_path:hsa04066", "kegg_path:hsa04151", "kegg_path:hsa04370", "kegg_path:hsa04510", "kegg_path:hsa04926", "kegg_path:hsa04933", "kegg_path:hsa05163", "kegg_path:hsa05165", "kegg_path:hsa05167", "kegg_path:hsa05200", "kegg_path:hsa05205", "kegg_path:hsa05206", "kegg_path:hsa05211", "kegg_path:hsa05212", "kegg_path:hsa05219", "kegg_path:hsa05323", "kegg_path:hsa05418", "R-HSA-109582", "R-HSA-114608", "R-HSA-1234158", "R-HSA-1234174", "R-HSA-1280215", "R-HSA-162582", "R-HSA-168256", "R-HSA-194138", "R-HSA-194313", "R-HSA-195399", "R-HSA-212436", "R-HSA-2262752", "R-HSA-449147", "R-HSA-6785807", "R-HSA-73857", "R-HSA-74160", "R-HSA-76002", "R-HSA-76005", "R-HSA-8864260", "R-HSA-8866910", "R-HSA-8953897", "R-HSA-9006934" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "J3KPA4", "ensembl_id": "None", "entrez_id": "ENSG00000112715", "chromosome_number": "6", "lastmodified": "2023-05-16T12:02:32.427835" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "2623" }, { "type": "SmallVariant", "id": "3354" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/VEGFA/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/VEGFA/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "871" }, { "type": "GeneCombination", "id": "1128" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/VEGFA/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/VEGFA/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/VEGFA/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }