Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/495/genes/?format=api
{ "data": [ { "type": "Gene", "id": "FZD2", "attributes": { "go_molecular_function": [ "protein binding", "transmembrane signaling receptor activity", "Wnt-activated receptor activity", "Wnt-protein binding", "G protein-coupled receptor activity" ], "pathway_id": [ "kegg_path:hsa04916", "R-HSA-372790", "kegg_path:hsa04310", "R-HSA-195721", "R-HSA-500792", "kegg_path:hsa04550", "kegg_path:hsa05165", "kegg_path:hsa04150", "kegg_path:hsa04934", "kegg_path:hsa05224", "R-HSA-4608870", "R-HSA-4086398", "kegg_path:hsa04390", "kegg_path:hsa05205", "kegg_path:hsa05010", "R-HSA-3858494", "kegg_path:hsa05225", "kegg_path:hsa04310", "kegg_path:hsa05217", "kegg_path:hsa05226", "kegg_path:hsa04916", "kegg_path:hsa05022", "R-HSA-201681", "R-HSA-4641262", "R-HSA-5140745", "kegg_path:hsa05200", "R-HSA-4086400", "kegg_path:hsa05010", "kegg_path:hsa05205", "kegg_path:hsa04390", "kegg_path:hsa05224", "kegg_path:hsa04934", "kegg_path:hsa04150", "kegg_path:hsa04550", "kegg_path:hsa05165", "kegg_path:hsa05200", "kegg_path:hsa05022", "kegg_path:hsa05226", "R-HSA-162582", "kegg_path:hsa05217", "R-HSA-373080", "kegg_path:hsa05225" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q14332", "ensembl_id": "ENSG00000180340", "entrez_id": "2535", "chromosome_number": "17", "lastmodified": "2021-10-18T11:00:44.723507" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1544" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FZD2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FZD2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "495" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FZD2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FZD2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FZD2/?format=api" } }, { "type": "Gene", "id": "MTHFR", "attributes": { "go_molecular_function": [ "catalytic activity", "flavin adenine dinucleotide binding", "methylenetetrahydrofolate reductase (NAD(P)H) activity", "FAD binding", "oxidoreductase activity" ], "pathway_id": [ "kegg_path:hsa01523", "R-HSA-1430728", "kegg_path:hsa01100", "R-HSA-196849", "R-HSA-196854", "kegg_path:hsa01200", "R-HSA-196757", "kegg_path:hsa00670" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P42898", "ensembl_id": "ENSG00000177000", "entrez_id": "4524", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.314165" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "928" }, { "type": "SmallVariant", "id": "1542" }, { "type": "SmallVariant", "id": "1550" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MTHFR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MTHFR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "293" }, { "type": "GeneCombination", "id": "495" }, { "type": "GeneCombination", "id": "498" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MTHFR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MTHFR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MTHFR/?format=api" } }, { "type": "Gene", "id": "SLC2A1", "attributes": { "go_molecular_function": [ "protein binding", "kinase binding", "D-glucose transmembrane transporter activity", "dehydroascorbic acid transmembrane transporter activity", "glucose transmembrane transporter activity", "identical protein binding" ], "pathway_id": [ "kegg_path:hsa04922", "R-HSA-5619102", "kegg_path:hsa05166", "R-HSA-189200", "kegg_path:hsa04066", "R-HSA-5619043", "R-HSA-196854", "kegg_path:hsa05200", "kegg_path:hsa05230", "R-HSA-1643685", "R-HSA-196849", "R-HSA-425407", "kegg_path:hsa04920", "kegg_path:hsa04919", "kegg_path:hsa04976", "kegg_path:hsa05211", "R-HSA-163685", "kegg_path:hsa04911", "kegg_path:hsa04931", "R-HSA-422356", "R-HSA-1430728", "R-HSA-382551", "R-HSA-71387", "R-HSA-5619115", "R-HSA-196836", "R-HSA-5653890" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P11166", "ensembl_id": "ENSG00000117394", "entrez_id": "6513", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.851003" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1543" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SLC2A1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SLC2A1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "495" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SLC2A1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SLC2A1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SLC2A1/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2024 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }