Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1109/genes/?format=api
{ "data": [ { "type": "Gene", "id": "FANCB", "attributes": { "go_molecular_function": [ "['protein binding']" ], "pathway_id": [ "kegg_path:hsa03460", "kegg_path:hsa03460", "R-HSA-6783310", "R-HSA-73894" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q8NB91", "ensembl_id": "None", "entrez_id": "ENSG00000181544", "chromosome_number": "X", "lastmodified": "2023-05-16T12:02:33.679654" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3297" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FANCB/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FANCB/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "1109" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FANCB/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FANCB/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FANCB/?format=api" } }, { "type": "Gene", "id": "GHRHR", "attributes": { "go_molecular_function": [ "['peptide hormone binding', 'growth hormone-releasing hormone receptor activity', 'G protein-coupled receptor activity', 'G protein-coupled peptide receptor activity', 'protein binding', 'growth factor binding']" ], "pathway_id": [ "kegg_path:hsa04080", "kegg_path:hsa04935", "kegg_path:hsa04080", "kegg_path:hsa04935", "R-HSA-162582", "R-HSA-1643685", "R-HSA-372790", "R-HSA-373080", "R-HSA-388396", "R-HSA-418555", "R-HSA-420092", "R-HSA-500792", "R-HSA-5663205", "R-HSA-9658195", "R-HSA-9660821", "R-HSA-9662851", "R-HSA-9664433" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q02643", "ensembl_id": "None", "entrez_id": "ENSG00000106128", "chromosome_number": "7", "lastmodified": "2023-05-16T12:02:33.566892" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "3187" }, { "type": "SmallVariant", "id": "3298" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GHRHR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GHRHR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "1065" }, { "type": "GeneCombination", "id": "1109" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GHRHR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GHRHR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GHRHR/?format=api" } }, { "type": "Gene", "id": "HOXA13", "attributes": { "go_molecular_function": [ "['sequence-specific DNA binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'DNA-binding transcription activator activity, RNA polymerase II-specific', 'DNA-binding transcription factor activity, RNA polymerase II-specific', 'DNA binding', 'sequence-specific double-stranded DNA binding']" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "None", "ensembl_id": "None", "entrez_id": "ENSG00000106031", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:45.003996" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1301" }, { "type": "SmallVariant", "id": "3295" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HOXA13/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HOXA13/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "410" }, { "type": "GeneCombination", "id": "1109" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HOXA13/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HOXA13/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/HOXA13/?format=api" } }, { "type": "Gene", "id": "KAT6B", "attributes": { "go_molecular_function": [ "['transcription coregulator activity', 'DNA binding', 'RNA polymerase II-specific DNA-binding transcription factor binding', 'acetyltransferase activity', 'protein binding', 'metal ion binding', 'histone binding', 'histone acetyltransferase activity']" ], "pathway_id": [ "R-HSA-3214847", "R-HSA-3247509", "R-HSA-4839726" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q8WYB5", "ensembl_id": "None", "entrez_id": "ENSG00000156650", "chromosome_number": "10", "lastmodified": "2023-05-16T12:02:33.654886" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "3282" }, { "type": "SmallVariant", "id": "3296" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/KAT6B/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/KAT6B/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "1105" }, { "type": "GeneCombination", "id": "1109" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/KAT6B/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/KAT6B/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/KAT6B/?format=api" } }, { "type": "Gene", "id": "OFD1", "attributes": { "go_molecular_function": [ "['alpha-tubulin binding', 'identical protein binding', 'protein binding', 'gamma-tubulin binding']" ], "pathway_id": [ "R-HSA-162582", "R-HSA-1640170", "R-HSA-1852241", "R-HSA-2565942", "R-HSA-380259", "R-HSA-380270", "R-HSA-380284", "R-HSA-380287", "R-HSA-380320", "R-HSA-453274", "R-HSA-5358351", "R-HSA-5610787", "R-HSA-5617833", "R-HSA-5620912", "R-HSA-68877", "R-HSA-68886", "R-HSA-69275", "R-HSA-69278", "R-HSA-8854518" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "O75665", "ensembl_id": "None", "entrez_id": "ENSG00000046651", "chromosome_number": "X", "lastmodified": "2021-10-18T11:00:44.915969" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "578" }, { "type": "SmallVariant", "id": "3294" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/OFD1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/OFD1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "199" }, { "type": "GeneCombination", "id": "1109" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/OFD1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/OFD1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/OFD1/?format=api" } }, { "type": "Gene", "id": "SRA1", "attributes": { "go_molecular_function": [ "['steroid receptor RNA activator RNA binding', 'nuclear receptor coactivator activity', 'transcription coactivator activity', 'DNA binding', 'protein binding']" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "Q9HD15", "ensembl_id": "None", "entrez_id": "ENSG00000213523", "chromosome_number": "5", "lastmodified": "2021-10-18T11:00:44.268998" }, "relationships": { "variant_set": { "meta": { "count": 7 }, "data": [ { "type": "SmallVariant", "id": "35" }, { "type": "SmallVariant", "id": "1211" }, { "type": "SmallVariant", "id": "1424" }, { "type": "SmallVariant", "id": "2777" }, { "type": "SmallVariant", "id": "3299" }, { "type": "SmallVariant", "id": "3301" }, { "type": "SmallVariant", "id": "3305" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SRA1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SRA1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 8 }, "data": [ { "type": "GeneCombination", "id": "14" }, { "type": "GeneCombination", "id": "386" }, { "type": "GeneCombination", "id": "448" }, { "type": "GeneCombination", "id": "928" }, { "type": "GeneCombination", "id": "1109" }, { "type": "GeneCombination", "id": "1110" }, { "type": "GeneCombination", "id": "1112" }, { "type": "GeneCombination", "id": "1124" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SRA1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SRA1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SRA1/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2024 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 6 } }