Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1074/genes/?format=api
{ "data": [ { "type": "Gene", "id": "GLI2", "attributes": { "go_molecular_function": [ "['zinc ion binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'sequence-specific double-stranded DNA binding', 'sequence-specific DNA binding', 'protein binding', 'DNA-binding transcription factor activity', 'promoter-specific chromatin binding', 'DNA-binding transcription factor activity, RNA polymerase II-specific']" ], "pathway_id": [ "kegg_path:hsa04340", "kegg_path:hsa04390", "kegg_path:hsa05200", "kegg_path:hsa05217", "R-HSA-162582", "R-HSA-212436", "R-HSA-5358351", "R-HSA-5610783", "R-HSA-5610787", "R-HSA-5632684", "R-HSA-5635851", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878166", "R-HSA-8941284", "R-HSA-8941326", "kegg_path:hsa04340", "kegg_path:hsa04390", "kegg_path:hsa05200", "kegg_path:hsa05217" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P10070", "ensembl_id": "None", "entrez_id": "ENSG00000074047", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.515380" }, "relationships": { "variant_set": { "meta": { "count": 14 }, "data": [ { "type": "SmallVariant", "id": "725" }, { "type": "SmallVariant", "id": "735" }, { "type": "SmallVariant", "id": "1217" }, { "type": "SmallVariant", "id": "1281" }, { "type": "SmallVariant", "id": "2493" }, { "type": "SmallVariant", "id": "2512" }, { "type": "SmallVariant", "id": "2514" }, { "type": "SmallVariant", "id": "3164" }, { "type": "SmallVariant", "id": "3199" }, { "type": "SmallVariant", "id": "3201" }, { "type": "SmallVariant", "id": "3213" }, { "type": "SmallVariant", "id": "3229" }, { "type": "SmallVariant", "id": "3265" }, { "type": "SmallVariant", "id": "3487" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GLI2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GLI2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 16 }, "data": [ { "type": "GeneCombination", "id": "232" }, { "type": "GeneCombination", "id": "235" }, { "type": "GeneCombination", "id": "407" }, { "type": "GeneCombination", "id": "387" }, { "type": "GeneCombination", "id": "844" }, { "type": "GeneCombination", "id": "852" }, { "type": "GeneCombination", "id": "853" }, { "type": "GeneCombination", "id": "1056" }, { "type": "GeneCombination", "id": "1068" }, { "type": "GeneCombination", "id": "1069" }, { "type": "GeneCombination", "id": "1081" }, { "type": "GeneCombination", "id": "1098" }, { "type": "GeneCombination", "id": "1102" }, { "type": "GeneCombination", "id": "1173" }, { "type": "GeneCombination", "id": "1074" }, { "type": "GeneCombination", "id": "1253" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GLI2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GLI2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GLI2/?format=api" } }, { "type": "Gene", "id": "GLI3", "attributes": { "go_molecular_function": [ "['chromatin binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'beta-catenin binding', 'metal ion binding', 'histone acetyltransferase binding', 'sequence-specific double-stranded DNA binding', 'DNA-binding transcription factor activity, RNA polymerase II-specific', 'mediator complex binding', 'protein binding', 'RNA polymerase II transcription regulatory region sequence-specific DNA binding', 'histone deacetylase binding', 'DNA-binding transcription factor activity']" ], "pathway_id": [ "kegg_path:hsa04024", "kegg_path:hsa04340", "kegg_path:hsa05200", "kegg_path:hsa05217", "R-HSA-162582", "R-HSA-212436", "R-HSA-5358351", "R-HSA-5610785", "R-HSA-5610787", "R-HSA-5632684", "R-HSA-5635851", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878166", "R-HSA-8940973", "R-HSA-8941326" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P10071", "ensembl_id": "None", "entrez_id": "ENSG00000106571", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:44.894304" }, "relationships": { "variant_set": { "meta": { "count": 16 }, "data": [ { "type": "SmallVariant", "id": "726" }, { "type": "SmallVariant", "id": "731" }, { "type": "SmallVariant", "id": "732" }, { "type": "SmallVariant", "id": "741" }, { "type": "SmallVariant", "id": "900" }, { "type": "SmallVariant", "id": "916" }, { "type": "SmallVariant", "id": "1300" }, { "type": "SmallVariant", "id": "2769" }, { "type": "SmallVariant", "id": "2834" }, { "type": "SmallVariant", "id": "2847" }, { "type": "SmallVariant", "id": "2889" }, { "type": "SmallVariant", "id": "2963" }, { "type": "SmallVariant", "id": "3180" }, { "type": "SmallVariant", "id": "3214" }, { "type": "SmallVariant", "id": "3230" }, { "type": "SmallVariant", "id": "3324" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GLI3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GLI3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 16 }, "data": [ { "type": "GeneCombination", "id": "236" }, { "type": "GeneCombination", "id": "232" }, { "type": "GeneCombination", "id": "234" }, { "type": "GeneCombination", "id": "287" }, { "type": "GeneCombination", "id": "279" }, { "type": "GeneCombination", "id": "410" }, { "type": "GeneCombination", "id": "926" }, { "type": "GeneCombination", "id": "942" }, { "type": "GeneCombination", "id": "957" }, { "type": "GeneCombination", "id": "986" }, { "type": "GeneCombination", "id": "1061" }, { "type": "GeneCombination", "id": "1081" }, { "type": "GeneCombination", "id": "1115" }, { "type": "GeneCombination", "id": "1118" }, { "type": "GeneCombination", "id": "1120" }, { "type": "GeneCombination", "id": "1074" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GLI3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GLI3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GLI3/?format=api" } }, { "type": "Gene", "id": "NR2F2", "attributes": { "go_molecular_function": [ "['zinc ion binding', 'sequence-specific DNA binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'retinoic acid binding', 'nuclear receptor activity', 'protein binding', 'protein homodimerization activity', 'DNA-binding transcription factor activity']" ], "pathway_id": [ "R-HSA-1266738", "R-HSA-381340" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P24468", "ensembl_id": "None", "entrez_id": "ENSG00000185551", "chromosome_number": "15", "lastmodified": "2023-05-16T12:02:33.600350" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3212" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NR2F2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NR2F2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "1074" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NR2F2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NR2F2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NR2F2/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }