Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/736/genes/?format=api
{ "data": [ { "type": "Gene", "id": "AR", "attributes": { "go_molecular_function": [ "['zinc ion binding', 'transcription cis-regulatory region binding', 'nuclear receptor activity', 'steroid binding', 'DNA-binding transcription factor activity, RNA polymerase II-specific', 'RNA polymerase II-specific DNA-binding transcription factor binding', 'protein binding', 'DNA-binding transcription factor activity', 'POU domain binding', 'androgen binding', 'transcription coactivator binding', 'chromatin binding', 'ATPase binding', 'beta-catenin binding', 'RNA polymerase II general transcription initiation factor binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'enzyme binding', 'DNA-binding transcription activator activity, RNA polymerase II-specific', 'signaling receptor binding']" ], "pathway_id": [ "kegg_path:hsa04114", "kegg_path:hsa05200", "kegg_path:hsa05215", "R-HSA-162582", "R-HSA-194315", "R-HSA-195258", "R-HSA-212436", "R-HSA-2262752", "R-HSA-2990846", "R-HSA-3108232", "R-HSA-3371497", "R-HSA-383280", "R-HSA-392499", "R-HSA-4090294", "R-HSA-5625740", "R-HSA-5625886", "R-HSA-5688426", "R-HSA-5689880", "R-HSA-597592", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878166", "R-HSA-8940973", "R-HSA-8941326", "R-HSA-8953897" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P10275", "ensembl_id": "None", "entrez_id": "ENSG00000169083", "chromosome_number": "X", "lastmodified": "2021-10-18T11:00:44.665425" }, "relationships": { "variant_set": { "meta": { "count": 15 }, "data": [ { "type": "SmallVariant", "id": "580" }, { "type": "CopyNumberVariant", "id": "2184" }, { "type": "SmallVariant", "id": "646" }, { "type": "SmallVariant", "id": "2159" }, { "type": "SmallVariant", "id": "2164" }, { "type": "SmallVariant", "id": "2168" }, { "type": "SmallVariant", "id": "2171" }, { "type": "SmallVariant", "id": "2173" }, { "type": "SmallVariant", "id": "2175" }, { "type": "SmallVariant", "id": "2177" }, { "type": "SmallVariant", "id": "2180" }, { "type": "SmallVariant", "id": "2182" }, { "type": "SmallVariant", "id": "3248" }, { "type": "SmallVariant", "id": "3292" }, { "type": "SmallVariant", "id": "3311" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 15 }, "data": [ { "type": "GeneCombination", "id": "200" }, { "type": "GeneCombination", "id": "217" }, { "type": "GeneCombination", "id": "736" }, { "type": "GeneCombination", "id": "737" }, { "type": "GeneCombination", "id": "738" }, { "type": "GeneCombination", "id": "739" }, { "type": "GeneCombination", "id": "740" }, { "type": "GeneCombination", "id": "741" }, { "type": "GeneCombination", "id": "742" }, { "type": "GeneCombination", "id": "743" }, { "type": "GeneCombination", "id": "744" }, { "type": "GeneCombination", "id": "745" }, { "type": "GeneCombination", "id": "1089" }, { "type": "GeneCombination", "id": "1108" }, { "type": "GeneCombination", "id": "1114" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/AR/?format=api" } }, { "type": "Gene", "id": "DGKK", "attributes": { "go_molecular_function": [ "metal ion binding", "NAD+ kinase activity", "diacylglycerol kinase activity", "ATP binding" ], "pathway_id": [ "R-HSA-76002", "kegg_path:hsa04070", "kegg_path:hsa00561", "R-HSA-109582", "kegg_path:hsa00564", "kegg_path:hsa01100", "R-HSA-114508", "kegg_path:hsa04072", "kegg_path:hsa05231", "R-HSA-388396", "R-HSA-416476", "R-HSA-162582", "R-HSA-372790" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q5KSL6", "ensembl_id": "ENSG00000274588", "entrez_id": "139189", "chromosome_number": "X", "lastmodified": "2022-08-04T14:14:59.419971" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2160" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/DGKK/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/DGKK/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "736" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/DGKK/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/DGKK/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/DGKK/?format=api" } }, { "type": "Gene", "id": "EGF", "attributes": { "go_molecular_function": [ "calcium ion binding", "protein binding", "epidermal growth factor receptor binding", "transmembrane receptor protein tyrosine kinase activator activity", "growth factor activity", "guanyl-nucleotide exchange factor activity" ], "pathway_id": [ "R-HSA-1236382", "R-HSA-5663202", "kegg_path:hsa05200", "kegg_path:hsa04540", "R-HSA-9665348", "R-HSA-179812", "kegg_path:hsa04020", "R-HSA-162582", "R-HSA-1963642", "R-HSA-9013507", "R-HSA-2219530", "R-HSA-182971", "kegg_path:hsa04012", "R-HSA-9006934", "R-HSA-157118", "R-HSA-76002", "kegg_path:hsa05235", "R-HSA-109582", "R-HSA-8848021", "R-HSA-9664565", "kegg_path:hsa04015", "R-HSA-199418", "R-HSA-5653656", "R-HSA-1251932", "kegg_path:hsa05210", "R-HSA-5673001", "kegg_path:hsa05219", "R-HSA-1250196", "R-HSA-1227986", "R-HSA-1236394", "R-HSA-1257604", "R-HSA-9006925", "R-HSA-177929", "kegg_path:hsa05214", "R-HSA-1227990", "R-HSA-5638303", "R-HSA-5637812", "R-HSA-76005", "R-HSA-8863795", "kegg_path:hsa05165", "kegg_path:hsa05215", "R-HSA-6811558", "kegg_path:hsa04014", "R-HSA-5683057", "kegg_path:hsa04066", "R-HSA-1643713", "R-HSA-5637810", "kegg_path:hsa04810", "kegg_path:hsa05231", "R-HSA-2219528", "R-HSA-180292", "R-HSA-180336", "kegg_path:hsa04068", "R-HSA-1963640", "R-HSA-8939211", "kegg_path:hsa01521", "R-HSA-6785631", "R-HSA-8856825", "kegg_path:hsa04510", "R-HSA-5637815", "kegg_path:hsa05226", "R-HSA-9006927", "R-HSA-9634638", "kegg_path:hsa05218", "kegg_path:hsa04072", "R-HSA-114608", "R-HSA-8856828", "kegg_path:hsa05224", "R-HSA-9012852", "R-HSA-212718", "kegg_path:hsa04010", "kegg_path:hsa05213", "kegg_path:hsa05223", "R-HSA-5684996", "R-HSA-9009391", "kegg_path:hsa04630", "kegg_path:hsa05160", "R-HSA-5638302", "R-HSA-9665686", "R-HSA-199991", "R-HSA-8847993", "R-HSA-9006931", "kegg_path:hsa05212", "kegg_path:hsa04151", "R-HSA-1643685" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P01133", "ensembl_id": "ENSG00000138798", "entrez_id": "1950", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:44.414266" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "1850" }, { "type": "SmallVariant", "id": "1883" }, { "type": "SmallVariant", "id": "1909" }, { "type": "SmallVariant", "id": "1956" }, { "type": "SmallVariant", "id": "2161" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/EGF/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/EGF/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "614" }, { "type": "GeneCombination", "id": "627" }, { "type": "GeneCombination", "id": "641" }, { "type": "GeneCombination", "id": "669" }, { "type": "GeneCombination", "id": "676" }, { "type": "GeneCombination", "id": "736" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/EGF/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/EGF/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/EGF/?format=api" } }, { "type": "Gene", "id": "FKBP4", "attributes": { "go_molecular_function": [ "GTP binding", "FK506 binding", "protein binding", "protein-macromolecule adaptor activity", "heat shock protein binding", "peptidyl-prolyl cis-trans isomerase activity", "glucocorticoid receptor binding", "tau protein binding", "phosphoprotein binding", "ATP binding", "RNA binding", "copper-dependent protein binding" ], "pathway_id": [ "R-HSA-162582", "R-HSA-9679191", "kegg_path:hsa04915", "R-HSA-8953897", "R-HSA-2262752", "R-HSA-3371556", "R-HSA-8939211", "R-HSA-1643685", "R-HSA-9018519", "R-HSA-9679506", "R-HSA-3371571", "R-HSA-3371568", "R-HSA-3371497", "R-HSA-5663205", "R-HSA-9006931" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q02790", "ensembl_id": "ENSG00000004478", "entrez_id": "2288", "chromosome_number": "12", "lastmodified": "2022-08-04T14:14:59.992107" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2162" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FKBP4/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FKBP4/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "736" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FKBP4/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FKBP4/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FKBP4/?format=api" } }, { "type": "Gene", "id": "GJA4", "attributes": { "go_molecular_function": [ "gap junction channel activity", "protein binding" ], "pathway_id": [ "R-HSA-157858", "R-HSA-190861", "R-HSA-199991", "R-HSA-5653656", "R-HSA-190828" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P35212", "ensembl_id": "ENSG00000187513", "entrez_id": "2701", "chromosome_number": "1", "lastmodified": "2022-08-04T14:14:57.693061" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2163" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GJA4/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GJA4/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "736" }, { "type": "GeneCombination", "id": "742" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GJA4/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GJA4/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GJA4/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 5 } }