Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1069/genes/?format=api
{ "data": [ { "type": "Gene", "id": "GLI2", "attributes": { "go_molecular_function": [ "['zinc ion binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'sequence-specific double-stranded DNA binding', 'sequence-specific DNA binding', 'protein binding', 'DNA-binding transcription factor activity', 'promoter-specific chromatin binding', 'DNA-binding transcription factor activity, RNA polymerase II-specific']" ], "pathway_id": [ "kegg_path:hsa04340", "kegg_path:hsa04390", "kegg_path:hsa05200", "kegg_path:hsa05217", "R-HSA-162582", "R-HSA-212436", "R-HSA-5358351", "R-HSA-5610783", "R-HSA-5610787", "R-HSA-5632684", "R-HSA-5635851", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878166", "R-HSA-8941284", "R-HSA-8941326", "kegg_path:hsa04340", "kegg_path:hsa04390", "kegg_path:hsa05200", "kegg_path:hsa05217" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P10070", "ensembl_id": "None", "entrez_id": "ENSG00000074047", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.515380" }, "relationships": { "variant_set": { "meta": { "count": 14 }, "data": [ { "type": "SmallVariant", "id": "725" }, { "type": "SmallVariant", "id": "735" }, { "type": "SmallVariant", "id": "1217" }, { "type": "SmallVariant", "id": "1281" }, { "type": "SmallVariant", "id": "2493" }, { "type": "SmallVariant", "id": "2512" }, { "type": "SmallVariant", "id": "2514" }, { "type": "SmallVariant", "id": "3164" }, { "type": "SmallVariant", "id": "3199" }, { "type": "SmallVariant", "id": "3201" }, { "type": "SmallVariant", "id": "3213" }, { "type": "SmallVariant", "id": "3229" }, { "type": "SmallVariant", "id": "3265" }, { "type": "SmallVariant", "id": "3487" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GLI2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GLI2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 16 }, "data": [ { "type": "GeneCombination", "id": "232" }, { "type": "GeneCombination", "id": "235" }, { "type": "GeneCombination", "id": "407" }, { "type": "GeneCombination", "id": "387" }, { "type": "GeneCombination", "id": "844" }, { "type": "GeneCombination", "id": "852" }, { "type": "GeneCombination", "id": "853" }, { "type": "GeneCombination", "id": "1056" }, { "type": "GeneCombination", "id": "1068" }, { "type": "GeneCombination", "id": "1069" }, { "type": "GeneCombination", "id": "1081" }, { "type": "GeneCombination", "id": "1098" }, { "type": "GeneCombination", "id": "1102" }, { "type": "GeneCombination", "id": "1173" }, { "type": "GeneCombination", "id": "1074" }, { "type": "GeneCombination", "id": "1253" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GLI2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GLI2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GLI2/?format=api" } }, { "type": "Gene", "id": "GPRC6A", "attributes": { "go_molecular_function": [ "['G protein-coupled receptor activity']" ], "pathway_id": [ "kegg_path:hsa04621", "R-HSA-162582", "R-HSA-372790", "R-HSA-388396", "R-HSA-416476", "R-HSA-420499", "R-HSA-500792" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q5T6X5", "ensembl_id": "None", "entrez_id": "ENSG00000173612", "chromosome_number": "6", "lastmodified": "2023-05-16T12:02:33.486621" }, "relationships": { "variant_set": { "meta": { "count": 7 }, "data": [ { "type": "SmallVariant", "id": "3157" }, { "type": "SmallVariant", "id": "3183" }, { "type": "SmallVariant", "id": "3186" }, { "type": "SmallVariant", "id": "3202" }, { "type": "SmallVariant", "id": "3204" }, { "type": "SmallVariant", "id": "3239" }, { "type": "SmallVariant", "id": "3312" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GPRC6A/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GPRC6A/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 11 }, "data": [ { "type": "GeneCombination", "id": "1053" }, { "type": "GeneCombination", "id": "1063" }, { "type": "GeneCombination", "id": "1064" }, { "type": "GeneCombination", "id": "1069" }, { "type": "GeneCombination", "id": "1070" }, { "type": "GeneCombination", "id": "1085" }, { "type": "GeneCombination", "id": "1102" }, { "type": "GeneCombination", "id": "1105" }, { "type": "GeneCombination", "id": "1107" }, { "type": "GeneCombination", "id": "1111" }, { "type": "GeneCombination", "id": "1114" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GPRC6A/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GPRC6A/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GPRC6A/?format=api" } }, { "type": "Gene", "id": "PROKR2", "attributes": { "go_molecular_function": [ "['neuropeptide Y receptor activity', 'protein binding', 'G protein-coupled receptor activity']" ], "pathway_id": [ "R-HSA-162582", "R-HSA-372790", "R-HSA-373076", "R-HSA-375276", "R-HSA-388396", "R-HSA-416476", "R-HSA-500792" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "None", "ensembl_id": "None", "entrez_id": "ENSG00000101292", "chromosome_number": "20", "lastmodified": "2021-10-18T11:00:44.395103" }, "relationships": { "variant_set": { "meta": { "count": 38 }, "data": [ { "type": "SmallVariant", "id": "26" }, { "type": "SmallVariant", "id": "78" }, { "type": "SmallVariant", "id": "331" }, { "type": "SmallVariant", "id": "383" }, { "type": "SmallVariant", "id": "397" }, { "type": "SmallVariant", "id": "400" }, { "type": "SmallVariant", "id": "402" }, { "type": "SmallVariant", "id": "857" }, { "type": "SmallVariant", "id": "1057" }, { "type": "SmallVariant", "id": "1798" }, { "type": "SmallVariant", "id": "1825" }, { "type": "SmallVariant", "id": "1826" }, { "type": "SmallVariant", "id": "1857" }, { "type": "SmallVariant", "id": "1864" }, { "type": "SmallVariant", "id": "1888" }, { "type": "SmallVariant", "id": "1892" }, { "type": "SmallVariant", "id": "1898" }, { "type": "SmallVariant", "id": "1901" }, { "type": "SmallVariant", "id": "1931" }, { "type": "SmallVariant", "id": "2398" }, { "type": "SmallVariant", "id": "2399" }, { "type": "SmallVariant", "id": "2502" }, { "type": "SmallVariant", "id": "2513" }, { "type": "SmallVariant", "id": "2517" }, { "type": "SmallVariant", "id": "2577" }, { "type": "SmallVariant", "id": "2579" }, { "type": "SmallVariant", "id": "2662" }, { "type": "SmallVariant", "id": "2678" }, { "type": "SmallVariant", "id": "2691" }, { "type": "SmallVariant", "id": "2696" }, { "type": "SmallVariant", "id": "2699" }, { "type": "SmallVariant", "id": "2719" }, { "type": "SmallVariant", "id": "2721" }, { "type": "SmallVariant", "id": "2725" }, { "type": "SmallVariant", "id": "2768" }, { "type": "SmallVariant", "id": "2829" }, { "type": "SmallVariant", "id": "2831" }, { "type": "SmallVariant", "id": "3175" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PROKR2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PROKR2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 52 }, "data": [ { "type": "GeneCombination", "id": "10" }, { "type": "GeneCombination", "id": "31" }, { "type": "GeneCombination", "id": "116" }, { "type": "GeneCombination", "id": "265" }, { "type": "GeneCombination", "id": "257" }, { "type": "GeneCombination", "id": "442" }, { "type": "GeneCombination", "id": "478" }, { "type": "GeneCombination", "id": "596" }, { "type": "GeneCombination", "id": "616" }, { "type": "GeneCombination", "id": "617" }, { "type": "GeneCombination", "id": "619" }, { "type": "GeneCombination", "id": "622" }, { "type": "GeneCombination", "id": "626" }, { "type": "GeneCombination", "id": "629" }, { "type": "GeneCombination", "id": "630" }, { "type": "GeneCombination", "id": "631" }, { "type": "GeneCombination", "id": "632" }, { "type": "GeneCombination", "id": "637" }, { "type": "GeneCombination", "id": "653" }, { "type": "GeneCombination", "id": "656" }, { "type": "GeneCombination", "id": "662" }, { "type": "GeneCombination", "id": "663" }, { "type": "GeneCombination", "id": "817" }, { "type": "GeneCombination", "id": "852" }, { "type": "GeneCombination", "id": "854" }, { "type": "GeneCombination", "id": "859" }, { "type": "GeneCombination", "id": "606" }, { "type": "GeneCombination", "id": "189" }, { "type": "GeneCombination", "id": "858" }, { "type": "GeneCombination", "id": "892" }, { "type": "GeneCombination", "id": "896" }, { "type": "GeneCombination", "id": "898" }, { "type": "GeneCombination", "id": "136" }, { "type": "GeneCombination", "id": "902" }, { "type": "GeneCombination", "id": "903" }, { "type": "GeneCombination", "id": "904" }, { "type": "GeneCombination", "id": "906" }, { "type": "GeneCombination", "id": "910" }, { "type": "GeneCombination", "id": "90" }, { "type": "GeneCombination", "id": "941" }, { "type": "GeneCombination", "id": "635" }, { "type": "GeneCombination", "id": "947" }, { "type": "GeneCombination", "id": "971" }, { "type": "GeneCombination", "id": "1061" }, { "type": "GeneCombination", "id": "1069" }, { "type": "GeneCombination", "id": "1080" }, { "type": "GeneCombination", "id": "1084" }, { "type": "GeneCombination", "id": "1088" }, { "type": "GeneCombination", "id": "1091" }, { "type": "GeneCombination", "id": "1092" }, { "type": "GeneCombination", "id": "1102" }, { "type": "GeneCombination", "id": "1111" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PROKR2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PROKR2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PROKR2/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }