Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/962/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ARHGAP35", "attributes": { "go_molecular_function": [ "['GTPase activator activity', 'GTP binding', 'DNA binding', 'protein-containing complex binding', 'GTPase activating protein binding', 'phospholipid binding', 'GTPase activity']" ], "pathway_id": [ "kegg_path:hsa04510", "kegg_path:hsa04611", "kegg_path:hsa04670", "kegg_path:hsa04810", "R-HSA-1266738", "R-HSA-162582", "R-HSA-194315", "R-HSA-194840", "R-HSA-373755", "R-HSA-400685", "R-HSA-416550", "R-HSA-422475", "R-HSA-8848021", "R-HSA-8849471", "R-HSA-9006927", "R-HSA-9675108" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9NRY4", "ensembl_id": "None", "entrez_id": "ENSG00000160007", "chromosome_number": "19", "lastmodified": "2023-05-16T12:02:33.104602" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2902" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ARHGAP35/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ARHGAP35/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "962" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ARHGAP35/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ARHGAP35/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ARHGAP35/?format=api" } }, { "type": "Gene", "id": "IL17RD", "attributes": { "go_molecular_function": [ "['interleukin-17 receptor activity']" ], "pathway_id": [ "R-HSA-162582", "R-HSA-5673001", "R-HSA-5674135", "R-HSA-5683057", "R-HSA-5684996" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q8NFM7", "ensembl_id": "None", "entrez_id": "ENSG00000144730", "chromosome_number": "3", "lastmodified": "2021-10-18T11:00:44.954610" }, "relationships": { "variant_set": { "meta": { "count": 18 }, "data": [ { "type": "SmallVariant", "id": "770" }, { "type": "SmallVariant", "id": "776" }, { "type": "SmallVariant", "id": "778" }, { "type": "SmallVariant", "id": "780" }, { "type": "SmallVariant", "id": "800" }, { "type": "SmallVariant", "id": "802" }, { "type": "SmallVariant", "id": "1831" }, { "type": "SmallVariant", "id": "1879" }, { "type": "SmallVariant", "id": "1897" }, { "type": "SmallVariant", "id": "2676" }, { "type": "SmallVariant", "id": "2780" }, { "type": "SmallVariant", "id": "2830" }, { "type": "SmallVariant", "id": "2833" }, { "type": "SmallVariant", "id": "2901" }, { "type": "SmallVariant", "id": "2977" }, { "type": "SmallVariant", "id": "3360" }, { "type": "SmallVariant", "id": "3382" }, { "type": "SmallVariant", "id": "3469" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/IL17RD/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/IL17RD/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 15 }, "data": [ { "type": "GeneCombination", "id": "242" }, { "type": "GeneCombination", "id": "245" }, { "type": "GeneCombination", "id": "251" }, { "type": "GeneCombination", "id": "625" }, { "type": "GeneCombination", "id": "671" }, { "type": "GeneCombination", "id": "891" }, { "type": "GeneCombination", "id": "929" }, { "type": "GeneCombination", "id": "635" }, { "type": "GeneCombination", "id": "942" }, { "type": "GeneCombination", "id": "243" }, { "type": "GeneCombination", "id": "962" }, { "type": "GeneCombination", "id": "993" }, { "type": "GeneCombination", "id": "244" }, { "type": "GeneCombination", "id": "1134" }, { "type": "GeneCombination", "id": "1164" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/IL17RD/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/IL17RD/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/IL17RD/?format=api" } }, { "type": "Gene", "id": "SMCHD1", "attributes": { "go_molecular_function": [ "['ATP hydrolysis activity', 'ATP binding', 'DNA binding', 'protein binding', 'protein homodimerization activity']" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "A6NHR9", "ensembl_id": "None", "entrez_id": "ENSG00000101596", "chromosome_number": "18", "lastmodified": "2021-10-18T11:00:44.630267" }, "relationships": { "variant_set": { "meta": { "count": 6 }, "data": [ { "type": "SmallVariant", "id": "100" }, { "type": "SmallVariant", "id": "2904" }, { "type": "SmallVariant", "id": "2928" }, { "type": "SmallVariant", "id": "2958" }, { "type": "SmallVariant", "id": "2970" }, { "type": "SmallVariant", "id": "2980" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SMCHD1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SMCHD1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "35" }, { "type": "GeneCombination", "id": "962" }, { "type": "GeneCombination", "id": "972" }, { "type": "GeneCombination", "id": "984" }, { "type": "GeneCombination", "id": "989" }, { "type": "GeneCombination", "id": "994" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SMCHD1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SMCHD1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SMCHD1/?format=api" } }, { "type": "Gene", "id": "TCF12", "attributes": { "go_molecular_function": [ "['RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'DNA-binding transcription activator activity, RNA polymerase II-specific', 'transcription cis-regulatory region binding', 'E-box binding', 'cAMP response element binding', 'DNA-binding transcription factor activity, RNA polymerase II-specific', 'sequence-specific double-stranded DNA binding', 'SMAD binding', 'protein heterodimerization activity', 'protein binding', 'HMG box domain binding', 'DNA-binding transcription factor binding', 'cis-regulatory region sequence-specific DNA binding', 'bHLH transcription factor binding', 'DNA-binding transcription factor activity']" ], "pathway_id": [ "R-HSA-1266738", "R-HSA-162582", "R-HSA-166520", "R-HSA-187037", "R-HSA-198725", "R-HSA-212436", "R-HSA-525793", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878171", "R-HSA-8939236", "R-HSA-9006934", "R-HSA-9031628" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q99081", "ensembl_id": "None", "entrez_id": "ENSG00000140262", "chromosome_number": "15", "lastmodified": "2023-05-16T12:02:33.110635" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "2903" }, { "type": "SmallVariant", "id": "2914" }, { "type": "SmallVariant", "id": "2920" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TCF12/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TCF12/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "962" }, { "type": "GeneCombination", "id": "967" }, { "type": "GeneCombination", "id": "969" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TCF12/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TCF12/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/TCF12/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }