Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/242/genes/?format=api
{ "data": [ { "type": "Gene", "id": "CHD7", "attributes": { "go_molecular_function": [ "['chromatin binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'protein binding', 'ATP hydrolysis activity', 'DNA helicase activity', 'promoter-specific chromatin binding', 'ATP binding']" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9P2D1", "ensembl_id": "None", "entrez_id": "ENSG00000171316", "chromosome_number": "8", "lastmodified": "2021-10-18T11:00:44.704701" }, "relationships": { "variant_set": { "meta": { "count": 70 }, "data": [ { "type": "SmallVariant", "id": "39" }, { "type": "SmallVariant", "id": "275" }, { "type": "SmallVariant", "id": "708" }, { "type": "SmallVariant", "id": "771" }, { "type": "SmallVariant", "id": "772" }, { "type": "SmallVariant", "id": "974" }, { "type": "SmallVariant", "id": "1158" }, { "type": "SmallVariant", "id": "1215" }, { "type": "SmallVariant", "id": "1495" }, { "type": "SmallVariant", "id": "1830" }, { "type": "SmallVariant", "id": "1853" }, { "type": "SmallVariant", "id": "1860" }, { "type": "SmallVariant", "id": "1882" }, { "type": "SmallVariant", "id": "1899" }, { "type": "SmallVariant", "id": "1905" }, { "type": "SmallVariant", "id": "1911" }, { "type": "SmallVariant", "id": "1912" }, { "type": "SmallVariant", "id": "1954" }, { "type": "SmallVariant", "id": "1968" }, { "type": "SmallVariant", "id": "2078" }, { "type": "SmallVariant", "id": "2401" }, { "type": "SmallVariant", "id": "2403" }, { "type": "SmallVariant", "id": "2494" }, { "type": "SmallVariant", "id": "2496" }, { "type": "SmallVariant", "id": "2500" }, { "type": "SmallVariant", "id": "2509" }, { "type": "SmallVariant", "id": "2518" }, { "type": "SmallVariant", "id": "2659" }, { "type": "SmallVariant", "id": "2661" }, { "type": "SmallVariant", "id": "2668" }, { "type": "SmallVariant", "id": "2674" }, { "type": "SmallVariant", "id": "2679" }, { "type": "SmallVariant", "id": "2702" }, { "type": "SmallVariant", "id": "2704" }, { "type": "SmallVariant", "id": "2706" }, { "type": "SmallVariant", "id": "2716" }, { "type": "SmallVariant", "id": "2720" }, { "type": "SmallVariant", "id": "2772" }, { "type": "SmallVariant", "id": "2818" }, { "type": "SmallVariant", "id": "2822" }, { "type": "SmallVariant", "id": "2823" }, { "type": "SmallVariant", "id": "2828" }, { "type": "SmallVariant", "id": "2837" }, { "type": "SmallVariant", "id": "2838" }, { "type": "SmallVariant", "id": "2841" }, { "type": "SmallVariant", "id": "2887" }, { "type": "SmallVariant", "id": "2932" }, { "type": "SmallVariant", "id": "2941" }, { "type": "SmallVariant", "id": "2945" }, { "type": "SmallVariant", "id": "2951" }, { "type": "SmallVariant", "id": "2952" }, { "type": "SmallVariant", "id": "2973" }, { "type": "SmallVariant", "id": "2986" }, { "type": "SmallVariant", "id": "3001" }, { "type": "SmallVariant", "id": "3005" }, { "type": "SmallVariant", "id": "3197" }, { "type": "SmallVariant", "id": "3223" }, { "type": "SmallVariant", "id": "3264" }, { "type": "SmallVariant", "id": "3321" }, { "type": "SmallVariant", "id": "3358" }, { "type": "SmallVariant", "id": "3359" }, { "type": "SmallVariant", "id": "3363" }, { "type": "SmallVariant", "id": "3376" }, { "type": "SmallVariant", "id": "3381" }, { "type": "SmallVariant", "id": "3384" }, { "type": "SmallVariant", "id": "3386" }, { "type": "SmallVariant", "id": "3472" }, { "type": "SmallVariant", "id": "3473" }, { "type": "SmallVariant", "id": "3475" }, { "type": "SmallVariant", "id": "3703" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CHD7/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CHD7/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 52 }, "data": [ { "type": "GeneCombination", "id": "16" }, { "type": "GeneCombination", "id": "98" }, { "type": "GeneCombination", "id": "227" }, { "type": "GeneCombination", "id": "242" }, { "type": "GeneCombination", "id": "371" }, { "type": "GeneCombination", "id": "387" }, { "type": "GeneCombination", "id": "478" }, { "type": "GeneCombination", "id": "618" }, { "type": "GeneCombination", "id": "627" }, { "type": "GeneCombination", "id": "634" }, { "type": "GeneCombination", "id": "636" }, { "type": "GeneCombination", "id": "639" }, { "type": "GeneCombination", "id": "643" }, { "type": "GeneCombination", "id": "661" }, { "type": "GeneCombination", "id": "666" }, { "type": "GeneCombination", "id": "675" }, { "type": "GeneCombination", "id": "891" }, { "type": "GeneCombination", "id": "718" }, { "type": "GeneCombination", "id": "819" }, { "type": "GeneCombination", "id": "845" }, { "type": "GeneCombination", "id": "847" }, { "type": "GeneCombination", "id": "818" }, { "type": "GeneCombination", "id": "885" }, { "type": "GeneCombination", "id": "606" }, { "type": "GeneCombination", "id": "888" }, { "type": "GeneCombination", "id": "892" }, { "type": "GeneCombination", "id": "899" }, { "type": "GeneCombination", "id": "312" }, { "type": "GeneCombination", "id": "846" }, { "type": "GeneCombination", "id": "939" }, { "type": "GeneCombination", "id": "941" }, { "type": "GeneCombination", "id": "944" }, { "type": "GeneCombination", "id": "945" }, { "type": "GeneCombination", "id": "949" }, { "type": "GeneCombination", "id": "956" }, { "type": "GeneCombination", "id": "974" }, { "type": "GeneCombination", "id": "978" }, { "type": "GeneCombination", "id": "980" }, { "type": "GeneCombination", "id": "982" }, { "type": "GeneCombination", "id": "990" }, { "type": "GeneCombination", "id": "1002" }, { "type": "GeneCombination", "id": "1003" }, { "type": "GeneCombination", "id": "1078" }, { "type": "GeneCombination", "id": "1080" }, { "type": "GeneCombination", "id": "1088" }, { "type": "GeneCombination", "id": "1097" }, { "type": "GeneCombination", "id": "1117" }, { "type": "GeneCombination", "id": "850" }, { "type": "GeneCombination", "id": "1165" }, { "type": "GeneCombination", "id": "1166" }, { "type": "GeneCombination", "id": "1167" }, { "type": "GeneCombination", "id": "1253" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CHD7/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CHD7/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CHD7/?format=api" } }, { "type": "Gene", "id": "GNRH1", "attributes": { "go_molecular_function": [ "['hormone activity', 'gonadotropin-releasing hormone receptor binding', 'gonadotropin hormone-releasing hormone activity']" ], "pathway_id": [ "kegg_path:hsa04080", "kegg_path:hsa04912", "kegg_path:hsa04929", "R-HSA-162582", "R-HSA-372790", "R-HSA-373076", "R-HSA-375281", "R-HSA-388396", "R-HSA-416476", "R-HSA-500792" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P01148", "ensembl_id": "None", "entrez_id": "ENSG00000147437", "chromosome_number": "8", "lastmodified": "2021-10-18T11:00:44.344397" }, "relationships": { "variant_set": { "meta": { "count": 8 }, "data": [ { "type": "SmallVariant", "id": "774" }, { "type": "SmallVariant", "id": "816" }, { "type": "SmallVariant", "id": "1974" }, { "type": "SmallVariant", "id": "2510" }, { "type": "SmallVariant", "id": "2776" }, { "type": "SmallVariant", "id": "2948" }, { "type": "SmallVariant", "id": "3377" }, { "type": "SmallVariant", "id": "3767" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GNRH1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GNRH1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 8 }, "data": [ { "type": "GeneCombination", "id": "242" }, { "type": "GeneCombination", "id": "257" }, { "type": "GeneCombination", "id": "289" }, { "type": "GeneCombination", "id": "851" }, { "type": "GeneCombination", "id": "928" }, { "type": "GeneCombination", "id": "981" }, { "type": "GeneCombination", "id": "678" }, { "type": "GeneCombination", "id": "1276" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GNRH1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GNRH1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GNRH1/?format=api" } }, { "type": "Gene", "id": "IL17RD", "attributes": { "go_molecular_function": [ "['interleukin-17 receptor activity']" ], "pathway_id": [ "R-HSA-162582", "R-HSA-5673001", "R-HSA-5674135", "R-HSA-5683057", "R-HSA-5684996" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q8NFM7", "ensembl_id": "None", "entrez_id": "ENSG00000144730", "chromosome_number": "3", "lastmodified": "2021-10-18T11:00:44.954610" }, "relationships": { "variant_set": { "meta": { "count": 18 }, "data": [ { "type": "SmallVariant", "id": "770" }, { "type": "SmallVariant", "id": "776" }, { "type": "SmallVariant", "id": "778" }, { "type": "SmallVariant", "id": "780" }, { "type": "SmallVariant", "id": "800" }, { "type": "SmallVariant", "id": "802" }, { "type": "SmallVariant", "id": "1831" }, { "type": "SmallVariant", "id": "1879" }, { "type": "SmallVariant", "id": "1897" }, { "type": "SmallVariant", "id": "2676" }, { "type": "SmallVariant", "id": "2780" }, { "type": "SmallVariant", "id": "2830" }, { "type": "SmallVariant", "id": "2833" }, { "type": "SmallVariant", "id": "2901" }, { "type": "SmallVariant", "id": "2977" }, { "type": "SmallVariant", "id": "3360" }, { "type": "SmallVariant", "id": "3382" }, { "type": "SmallVariant", "id": "3469" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/IL17RD/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/IL17RD/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 15 }, "data": [ { "type": "GeneCombination", "id": "242" }, { "type": "GeneCombination", "id": "245" }, { "type": "GeneCombination", "id": "251" }, { "type": "GeneCombination", "id": "625" }, { "type": "GeneCombination", "id": "671" }, { "type": "GeneCombination", "id": "891" }, { "type": "GeneCombination", "id": "929" }, { "type": "GeneCombination", "id": "635" }, { "type": "GeneCombination", "id": "942" }, { "type": "GeneCombination", "id": "243" }, { "type": "GeneCombination", "id": "962" }, { "type": "GeneCombination", "id": "993" }, { "type": "GeneCombination", "id": "244" }, { "type": "GeneCombination", "id": "1134" }, { "type": "GeneCombination", "id": "1164" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/IL17RD/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/IL17RD/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/IL17RD/?format=api" } }, { "type": "Gene", "id": "RNF216", "attributes": { "go_molecular_function": [ "['ubiquitin protein ligase activity', 'protein binding', 'metal ion binding']" ], "pathway_id": [ "R-HSA-168249", "R-HSA-168256", "R-HSA-168928", "R-HSA-936440" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q9NWF9", "ensembl_id": "None", "entrez_id": "ENSG00000011275", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:44.917313" }, "relationships": { "variant_set": { "meta": { "count": 9 }, "data": [ { "type": "SmallVariant", "id": "36" }, { "type": "SmallVariant", "id": "586" }, { "type": "SmallVariant", "id": "773" }, { "type": "SmallVariant", "id": "1799" }, { "type": "SmallVariant", "id": "2933" }, { "type": "SmallVariant", "id": "2978" }, { "type": "SmallVariant", "id": "3198" }, { "type": "SmallVariant", "id": "3238" }, { "type": "SmallVariant", "id": "3246" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RNF216/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RNF216/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 9 }, "data": [ { "type": "GeneCombination", "id": "14" }, { "type": "GeneCombination", "id": "203" }, { "type": "GeneCombination", "id": "242" }, { "type": "GeneCombination", "id": "596" }, { "type": "GeneCombination", "id": "974" }, { "type": "GeneCombination", "id": "993" }, { "type": "GeneCombination", "id": "1068" }, { "type": "GeneCombination", "id": "1085" }, { "type": "GeneCombination", "id": "1087" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RNF216/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RNF216/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/RNF216/?format=api" } }, { "type": "Gene", "id": "SEMA7A", "attributes": { "go_molecular_function": [ "['integrin binding', 'semaphorin receptor binding', 'protein binding', 'chemorepellent activity']" ], "pathway_id": [ "kegg_path:hsa04360", "R-HSA-1266738", "R-HSA-373755", "R-HSA-416700", "R-HSA-422475", "R-HSA-9675108" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "O75326", "ensembl_id": "None", "entrez_id": "ENSG00000138623", "chromosome_number": "15", "lastmodified": "2021-10-18T11:00:44.948272" }, "relationships": { "variant_set": { "meta": { "count": 10 }, "data": [ { "type": "SmallVariant", "id": "775" }, { "type": "SmallVariant", "id": "1895" }, { "type": "SmallVariant", "id": "1940" }, { "type": "SmallVariant", "id": "1965" }, { "type": "SmallVariant", "id": "1972" }, { "type": "SmallVariant", "id": "2580" }, { "type": "SmallVariant", "id": "2673" }, { "type": "SmallVariant", "id": "2711" }, { "type": "SmallVariant", "id": "2733" }, { "type": "SmallVariant", "id": "2961" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SEMA7A/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SEMA7A/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 9 }, "data": [ { "type": "GeneCombination", "id": "242" }, { "type": "GeneCombination", "id": "633" }, { "type": "GeneCombination", "id": "657" }, { "type": "GeneCombination", "id": "673" }, { "type": "GeneCombination", "id": "677" }, { "type": "GeneCombination", "id": "859" }, { "type": "GeneCombination", "id": "890" }, { "type": "GeneCombination", "id": "901" }, { "type": "GeneCombination", "id": "985" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SEMA7A/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SEMA7A/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SEMA7A/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 5 } }