Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/200/genes/?format=api
{ "data": [ { "type": "Gene", "id": "AR", "attributes": { "go_molecular_function": [ "['zinc ion binding', 'transcription cis-regulatory region binding', 'nuclear receptor activity', 'steroid binding', 'DNA-binding transcription factor activity, RNA polymerase II-specific', 'RNA polymerase II-specific DNA-binding transcription factor binding', 'protein binding', 'DNA-binding transcription factor activity', 'POU domain binding', 'androgen binding', 'transcription coactivator binding', 'chromatin binding', 'ATPase binding', 'beta-catenin binding', 'RNA polymerase II general transcription initiation factor binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'enzyme binding', 'DNA-binding transcription activator activity, RNA polymerase II-specific', 'signaling receptor binding']" ], "pathway_id": [ "kegg_path:hsa04114", "kegg_path:hsa05200", "kegg_path:hsa05215", "R-HSA-162582", "R-HSA-194315", "R-HSA-195258", "R-HSA-212436", "R-HSA-2262752", "R-HSA-2990846", "R-HSA-3108232", "R-HSA-3371497", "R-HSA-383280", "R-HSA-392499", "R-HSA-4090294", "R-HSA-5625740", "R-HSA-5625886", "R-HSA-5688426", "R-HSA-5689880", "R-HSA-597592", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878166", "R-HSA-8940973", "R-HSA-8941326", "R-HSA-8953897" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P10275", "ensembl_id": "None", "entrez_id": "ENSG00000169083", "chromosome_number": "X", "lastmodified": "2021-10-18T11:00:44.665425" }, "relationships": { "variant_set": { "meta": { "count": 15 }, "data": [ { "type": "SmallVariant", "id": "580" }, { "type": "CopyNumberVariant", "id": "2184" }, { "type": "SmallVariant", "id": "646" }, { "type": "SmallVariant", "id": "2159" }, { "type": "SmallVariant", "id": "2164" }, { "type": "SmallVariant", "id": "2168" }, { "type": "SmallVariant", "id": "2171" }, { "type": "SmallVariant", "id": "2173" }, { "type": "SmallVariant", "id": "2175" }, { "type": "SmallVariant", "id": "2177" }, { "type": "SmallVariant", "id": "2180" }, { "type": "SmallVariant", "id": "2182" }, { "type": "SmallVariant", "id": "3248" }, { "type": "SmallVariant", "id": "3292" }, { "type": "SmallVariant", "id": "3311" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 15 }, "data": [ { "type": "GeneCombination", "id": "200" }, { "type": "GeneCombination", "id": "217" }, { "type": "GeneCombination", "id": "736" }, { "type": "GeneCombination", "id": "737" }, { "type": "GeneCombination", "id": "738" }, { "type": "GeneCombination", "id": "739" }, { "type": "GeneCombination", "id": "740" }, { "type": "GeneCombination", "id": "741" }, { "type": "GeneCombination", "id": "742" }, { "type": "GeneCombination", "id": "743" }, { "type": "GeneCombination", "id": "744" }, { "type": "GeneCombination", "id": "745" }, { "type": "GeneCombination", "id": "1089" }, { "type": "GeneCombination", "id": "1108" }, { "type": "GeneCombination", "id": "1114" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/AR/?format=api" } }, { "type": "Gene", "id": "HOXB6", "attributes": { "go_molecular_function": [ "protein binding", "RNA binding", "sequence-specific double-stranded DNA binding", "DNA-binding transcription factor activity, RNA polymerase II-specific", "DNA-binding transcription factor activity", "DNA binding" ], "pathway_id": [], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P17509", "ensembl_id": "ENSG00000108511", "entrez_id": "3216", "chromosome_number": "17", "lastmodified": "2021-10-18T11:00:44.683681" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "579" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HOXB6/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HOXB6/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "200" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HOXB6/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HOXB6/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/HOXB6/?format=api" } }, { "type": "Gene", "id": "MAMLD1", "attributes": { "go_molecular_function": [ "['molecular_function']" ], "pathway_id": [ "R-HSA-1266738", "R-HSA-157118", "R-HSA-162582", "R-HSA-1643685", "R-HSA-186712", "R-HSA-1912408", "R-HSA-1912422", "R-HSA-1980143", "R-HSA-1980145", "R-HSA-210744", "R-HSA-2122947", "R-HSA-212436", "R-HSA-2197563", "R-HSA-2644602", "R-HSA-2644603", "R-HSA-2644606", "R-HSA-2894858", "R-HSA-2894862", "R-HSA-350054", "R-HSA-5663202", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878159", "R-HSA-8941856", "R-HSA-9012852", "R-HSA-9013508", "R-HSA-9013694", "R-HSA-9013695", "R-HSA-1266738", "R-HSA-157118", "R-HSA-162582", "R-HSA-1643685", "R-HSA-186712", "R-HSA-1912408", "R-HSA-1912422", "R-HSA-1980143", "R-HSA-1980145", "R-HSA-210744", "R-HSA-2122947", "R-HSA-212436", "R-HSA-2197563", "R-HSA-2644602", "R-HSA-2644603", "R-HSA-2644606", "R-HSA-2894858", "R-HSA-2894862", "R-HSA-350054", "R-HSA-5663202", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878159", "R-HSA-8941856", "R-HSA-9012852", "R-HSA-9013508", "R-HSA-9013694", "R-HSA-9013695" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q13495", "ensembl_id": "None", "entrez_id": "ENSG00000013619", "chromosome_number": "X", "lastmodified": "2021-10-18T11:00:44.997839" }, "relationships": { "variant_set": { "meta": { "count": 22 }, "data": [ { "type": "SmallVariant", "id": "581" }, { "type": "SmallVariant", "id": "717" }, { "type": "SmallVariant", "id": "722" }, { "type": "SmallVariant", "id": "729" }, { "type": "SmallVariant", "id": "733" }, { "type": "SmallVariant", "id": "736" }, { "type": "SmallVariant", "id": "742" }, { "type": "SmallVariant", "id": "745" }, { "type": "SmallVariant", "id": "752" }, { "type": "SmallVariant", "id": "757" }, { "type": "SmallVariant", "id": "1268" }, { "type": "SmallVariant", "id": "1278" }, { "type": "SmallVariant", "id": "1280" }, { "type": "SmallVariant", "id": "1283" }, { "type": "SmallVariant", "id": "1294" }, { "type": "SmallVariant", "id": "1310" }, { "type": "SmallVariant", "id": "1316" }, { "type": "SmallVariant", "id": "3192" }, { "type": "SmallVariant", "id": "3200" }, { "type": "SmallVariant", "id": "3252" }, { "type": "SmallVariant", "id": "3259" }, { "type": "SmallVariant", "id": "3325" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAMLD1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAMLD1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 26 }, "data": [ { "type": "GeneCombination", "id": "236" }, { "type": "GeneCombination", "id": "240" }, { "type": "GeneCombination", "id": "200" }, { "type": "GeneCombination", "id": "237" }, { "type": "GeneCombination", "id": "238" }, { "type": "GeneCombination", "id": "231" }, { "type": "GeneCombination", "id": "232" }, { "type": "GeneCombination", "id": "233" }, { "type": "GeneCombination", "id": "234" }, { "type": "GeneCombination", "id": "235" }, { "type": "GeneCombination", "id": "239" }, { "type": "GeneCombination", "id": "406" }, { "type": "GeneCombination", "id": "407" }, { "type": "GeneCombination", "id": "408" }, { "type": "GeneCombination", "id": "405" }, { "type": "GeneCombination", "id": "409" }, { "type": "GeneCombination", "id": "410" }, { "type": "GeneCombination", "id": "411" }, { "type": "GeneCombination", "id": "412" }, { "type": "GeneCombination", "id": "1067" }, { "type": "GeneCombination", "id": "1068" }, { "type": "GeneCombination", "id": "1091" }, { "type": "GeneCombination", "id": "1092" }, { "type": "GeneCombination", "id": "1095" }, { "type": "GeneCombination", "id": "1120" }, { "type": "GeneCombination", "id": "1122" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAMLD1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAMLD1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MAMLD1/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }