Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/919/genes/?format=api
{ "data": [ { "type": "Gene", "id": "LRRK2", "attributes": { "go_molecular_function": [ "['signaling receptor complex adaptor activity', 'protein serine/threonine kinase activity', 'MAP kinase kinase kinase activity', 'protein serine kinase activity', 'microtubule binding', 'actin binding', 'protein binding', 'identical protein binding', 'tubulin binding', 'syntaxin-1 binding', 'GTPase activator activity', 'small GTPase binding', 'kinase activity', 'magnesium ion binding', 'beta-catenin destruction complex binding', 'co-receptor binding', 'GTPase activity', 'protein kinase activity', 'SNARE binding', 'JUN kinase kinase kinase activity', 'ATP binding', 'clathrin binding', 'peroxidase inhibitor activity', 'protein homodimerization activity', 'protein serine/threonine phosphatase activity', 'transmembrane transporter binding', 'GTP binding', 'GTP-dependent protein kinase activity', 'protein kinase A binding', 'protein serine/threonine/tyrosine kinase activity']" ], "pathway_id": [ "kegg_path:hsa05012", "kegg_path:hsa05022", "kegg_path:hsa05012", "kegg_path:hsa05022", "R-HSA-162582", "R-HSA-8848021", "R-HSA-8857538", "R-HSA-9006927" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q5S007", "ensembl_id": "None", "entrez_id": "ENSG00000188906", "chromosome_number": "12", "lastmodified": "2023-05-16T12:02:32.741378" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2753" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LRRK2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LRRK2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "919" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LRRK2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LRRK2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/LRRK2/?format=api" } }, { "type": "Gene", "id": "PRKN", "attributes": { "go_molecular_function": [ "['zinc ion binding', 'kinase binding', 'actin binding', 'protein binding', 'transcription corepressor activity', 'identical protein binding', 'ubiquitin protein ligase activity', 'SH3 domain binding', 'tubulin binding', 'ubiquitin binding', 'chaperone binding', 'cullin family protein binding', 'ubiquitin conjugating enzyme binding', 'heat shock protein binding', 'Hsp70 protein binding', 'G protein-coupled receptor binding', 'F-box domain binding', 'beta-catenin binding', 'PDZ domain binding', 'phospholipase binding', 'ubiquitin protein ligase binding', 'ubiquitin-protein transferase activity', 'protein kinase binding', 'enzyme binding', 'protein-containing complex binding', 'ubiquitin-specific protease binding', 'histone deacetylase binding']" ], "pathway_id": [ "kegg_path:hsa04120", "kegg_path:hsa04137", "kegg_path:hsa04141", "kegg_path:hsa05012", "kegg_path:hsa05014", "kegg_path:hsa05022", "R-HSA-1280218", "R-HSA-1632852", "R-HSA-168256", "R-HSA-392499", "R-HSA-5205647", "R-HSA-5205685", "R-HSA-5688426", "R-HSA-5689877", "R-HSA-597592", "R-HSA-9612973", "R-HSA-9646399", "R-HSA-9663891", "R-HSA-977225", "R-HSA-983168", "R-HSA-983169" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "O60260", "ensembl_id": "None", "entrez_id": "ENSG00000185345", "chromosome_number": "6", "lastmodified": "2021-10-18T11:00:44.312064" }, "relationships": { "variant_set": { "meta": { "count": 9 }, "data": [ { "type": "SmallVariant", "id": "266" }, { "type": "CopyNumberVariant", "id": "445" }, { "type": "CopyNumberVariant", "id": "446" }, { "type": "SmallVariant", "id": "262" }, { "type": "SmallVariant", "id": "265" }, { "type": "SmallVariant", "id": "268" }, { "type": "SmallVariant", "id": "440" }, { "type": "SmallVariant", "id": "442" }, { "type": "SmallVariant", "id": "2752" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PRKN/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PRKN/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "96" }, { "type": "GeneCombination", "id": "917" }, { "type": "GeneCombination", "id": "918" }, { "type": "GeneCombination", "id": "919" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PRKN/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PRKN/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PRKN/?format=api" } }, { "type": "Gene", "id": "TARDBP", "attributes": { "go_molecular_function": [ "['RNA polymerase II cis-regulatory region sequence-specific DNA binding', \"mRNA 3'-UTR binding\", 'pre-mRNA intronic binding', 'double-stranded DNA binding', 'protein binding', 'RNA binding', 'identical protein binding']" ], "pathway_id": [ "kegg_path:hsa03013", "kegg_path:hsa03015", "kegg_path:hsa05014", "kegg_path:hsa05022", "kegg_path:hsa03013", "kegg_path:hsa03015", "kegg_path:hsa05014", "kegg_path:hsa05022", "kegg_path:hsa03013", "kegg_path:hsa03015", "kegg_path:hsa05014", "kegg_path:hsa05022" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q13148", "ensembl_id": "None", "entrez_id": "ENSG00000120948", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.778821" }, "relationships": { "variant_set": { "meta": { "count": 12 }, "data": [ { "type": "SmallVariant", "id": "540" }, { "type": "SmallVariant", "id": "871" }, { "type": "SmallVariant", "id": "932" }, { "type": "SmallVariant", "id": "1430" }, { "type": "SmallVariant", "id": "1695" }, { "type": "SmallVariant", "id": "1704" }, { "type": "SmallVariant", "id": "2750" }, { "type": "SmallVariant", "id": "3060" }, { "type": "SmallVariant", "id": "3416" }, { "type": "SmallVariant", "id": "3440" }, { "type": "SmallVariant", "id": "3444" }, { "type": "SmallVariant", "id": "3607" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TARDBP/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TARDBP/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 13 }, "data": [ { "type": "GeneCombination", "id": "183" }, { "type": "GeneCombination", "id": "271" }, { "type": "GeneCombination", "id": "295" }, { "type": "GeneCombination", "id": "452" }, { "type": "GeneCombination", "id": "916" }, { "type": "GeneCombination", "id": "917" }, { "type": "GeneCombination", "id": "919" }, { "type": "GeneCombination", "id": "553" }, { "type": "GeneCombination", "id": "1027" }, { "type": "GeneCombination", "id": "1128" }, { "type": "GeneCombination", "id": "1146" }, { "type": "GeneCombination", "id": "1155" }, { "type": "GeneCombination", "id": "1157" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TARDBP/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TARDBP/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/TARDBP/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }