Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/170/genes/?format=api
{ "data": [ { "type": "Gene", "id": "CA2", "attributes": { "go_molecular_function": [ "lyase activity", "metal ion binding", "carbonate dehydratase activity" ], "pathway_id": [ "kegg_path:hsa00910", "kegg_path:hsa04976", "R-HSA-1237044", "kegg_path:hsa04964", "kegg_path:hsa04972", "R-HSA-1247673", "R-HSA-382551", "R-HSA-1430728", "kegg_path:hsa04971", "R-HSA-1480926", "kegg_path:hsa01100", "R-HSA-1475029", "kegg_path:hsa04966" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P00918", "ensembl_id": "ENSG00000104267", "entrez_id": "760", "chromosome_number": "8", "lastmodified": "2021-10-18T11:00:44.232326" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "514" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CA2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CA2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "170" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CA2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CA2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CA2/?format=api" } }, { "type": "Gene", "id": "LARP7", "attributes": { "go_molecular_function": [ "7SK snRNA binding", "protein binding", "RNA binding", "nucleic acid binding", "U6 snRNA binding" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "Q4G0J3", "ensembl_id": "ENSG00000174720", "entrez_id": "51574", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:44.853793" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "516" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LARP7/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LARP7/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "170" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LARP7/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LARP7/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/LARP7/?format=api" } }, { "type": "Gene", "id": "MCCC2", "attributes": { "go_molecular_function": [ "protein binding", "ATP binding", "methylcrotonoyl-CoA carboxylase activity", "nucleotide binding", "ligase activity" ], "pathway_id": [ "R-HSA-196854", "kegg_path:hsa01100", "R-HSA-70895", "R-HSA-71291", "R-HSA-196780", "R-HSA-3371599", "R-HSA-1430728", "kegg_path:hsa00280", "R-HSA-5668914", "R-HSA-3371599", "R-HSA-196780", "R-HSA-71291", "R-HSA-70895", "R-HSA-3296482", "R-HSA-1643685", "R-HSA-196849", "kegg_path:hsa01100", "R-HSA-3323169", "R-HSA-196854", "R-HSA-3323169", "R-HSA-1643685", "R-HSA-196849", "R-HSA-3296482", "R-HSA-5668914", "kegg_path:hsa00280", "R-HSA-1430728" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q9HCC0", "ensembl_id": "ENSG00000131844", "entrez_id": "64087", "chromosome_number": "5", "lastmodified": "2021-10-18T11:00:44.284558" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "513" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MCCC2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MCCC2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "170" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MCCC2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MCCC2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MCCC2/?format=api" } }, { "type": "Gene", "id": "SPG11", "attributes": { "go_molecular_function": [ "['protein binding']" ], "pathway_id": [ "kegg_path:hsa05014", "kegg_path:hsa05022" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q96JI7", "ensembl_id": "None", "entrez_id": "ENSG00000104133", "chromosome_number": "15", "lastmodified": "2021-10-18T11:00:45.010383" }, "relationships": { "variant_set": { "meta": { "count": 10 }, "data": [ { "type": "SmallVariant", "id": "515" }, { "type": "SmallVariant", "id": "691" }, { "type": "SmallVariant", "id": "1377" }, { "type": "SmallVariant", "id": "2042" }, { "type": "SmallVariant", "id": "2043" }, { "type": "SmallVariant", "id": "2091" }, { "type": "SmallVariant", "id": "2097" }, { "type": "SmallVariant", "id": "2098" }, { "type": "SmallVariant", "id": "3062" }, { "type": "SmallVariant", "id": "3612" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SPG11/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SPG11/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 8 }, "data": [ { "type": "GeneCombination", "id": "170" }, { "type": "GeneCombination", "id": "222" }, { "type": "GeneCombination", "id": "433" }, { "type": "GeneCombination", "id": "703" }, { "type": "GeneCombination", "id": "726" }, { "type": "GeneCombination", "id": "724" }, { "type": "GeneCombination", "id": "1027" }, { "type": "GeneCombination", "id": "1214" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SPG11/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SPG11/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SPG11/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }