Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1089/genes/?format=api
{ "data": [ { "type": "Gene", "id": "AR", "attributes": { "go_molecular_function": [ "['zinc ion binding', 'transcription cis-regulatory region binding', 'nuclear receptor activity', 'steroid binding', 'DNA-binding transcription factor activity, RNA polymerase II-specific', 'RNA polymerase II-specific DNA-binding transcription factor binding', 'protein binding', 'DNA-binding transcription factor activity', 'POU domain binding', 'androgen binding', 'transcription coactivator binding', 'chromatin binding', 'ATPase binding', 'beta-catenin binding', 'RNA polymerase II general transcription initiation factor binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'enzyme binding', 'DNA-binding transcription activator activity, RNA polymerase II-specific', 'signaling receptor binding']" ], "pathway_id": [ "kegg_path:hsa04114", "kegg_path:hsa05200", "kegg_path:hsa05215", "R-HSA-162582", "R-HSA-194315", "R-HSA-195258", "R-HSA-212436", "R-HSA-2262752", "R-HSA-2990846", "R-HSA-3108232", "R-HSA-3371497", "R-HSA-383280", "R-HSA-392499", "R-HSA-4090294", "R-HSA-5625740", "R-HSA-5625886", "R-HSA-5688426", "R-HSA-5689880", "R-HSA-597592", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878166", "R-HSA-8940973", "R-HSA-8941326", "R-HSA-8953897" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P10275", "ensembl_id": "None", "entrez_id": "ENSG00000169083", "chromosome_number": "X", "lastmodified": "2021-10-18T11:00:44.665425" }, "relationships": { "variant_set": { "meta": { "count": 15 }, "data": [ { "type": "SmallVariant", "id": "580" }, { "type": "CopyNumberVariant", "id": "2184" }, { "type": "SmallVariant", "id": "646" }, { "type": "SmallVariant", "id": "2159" }, { "type": "SmallVariant", "id": "2164" }, { "type": "SmallVariant", "id": "2168" }, { "type": "SmallVariant", "id": "2171" }, { "type": "SmallVariant", "id": "2173" }, { "type": "SmallVariant", "id": "2175" }, { "type": "SmallVariant", "id": "2177" }, { "type": "SmallVariant", "id": "2180" }, { "type": "SmallVariant", "id": "2182" }, { "type": "SmallVariant", "id": "3248" }, { "type": "SmallVariant", "id": "3292" }, { "type": "SmallVariant", "id": "3311" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 15 }, "data": [ { "type": "GeneCombination", "id": "200" }, { "type": "GeneCombination", "id": "217" }, { "type": "GeneCombination", "id": "736" }, { "type": "GeneCombination", "id": "737" }, { "type": "GeneCombination", "id": "738" }, { "type": "GeneCombination", "id": "739" }, { "type": "GeneCombination", "id": "740" }, { "type": "GeneCombination", "id": "741" }, { "type": "GeneCombination", "id": "742" }, { "type": "GeneCombination", "id": "743" }, { "type": "GeneCombination", "id": "744" }, { "type": "GeneCombination", "id": "745" }, { "type": "GeneCombination", "id": "1089" }, { "type": "GeneCombination", "id": "1108" }, { "type": "GeneCombination", "id": "1114" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/AR/?format=api" } }, { "type": "Gene", "id": "GHR", "attributes": { "go_molecular_function": [ "['peptide hormone binding', 'proline-rich region binding', 'SH2 domain binding', 'growth hormone receptor activity', 'protein kinase binding', 'cytokine binding', 'protein phosphatase binding', 'protein binding', 'growth factor binding', 'protein homodimerization activity', 'cytokine receptor activity', 'identical protein binding']" ], "pathway_id": [ "kegg_path:hsa04060", "kegg_path:hsa04080", "kegg_path:hsa04151", "kegg_path:hsa04630", "kegg_path:hsa04935", "R-HSA-1170546", "R-HSA-1280215", "R-HSA-168256", "R-HSA-982772" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P10912", "ensembl_id": "None", "entrez_id": "ENSG00000112964", "chromosome_number": "5", "lastmodified": "2021-10-18T11:00:44.556257" }, "relationships": { "variant_set": { "meta": { "count": 9 }, "data": [ { "type": "SmallVariant", "id": "1957" }, { "type": "SmallVariant", "id": "1967" }, { "type": "SmallVariant", "id": "3219" }, { "type": "SmallVariant", "id": "3222" }, { "type": "SmallVariant", "id": "3232" }, { "type": "SmallVariant", "id": "3249" }, { "type": "SmallVariant", "id": "3269" }, { "type": "SmallVariant", "id": "3279" }, { "type": "SmallVariant", "id": "3330" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GHR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GHR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 10 }, "data": [ { "type": "GeneCombination", "id": "669" }, { "type": "GeneCombination", "id": "674" }, { "type": "GeneCombination", "id": "1076" }, { "type": "GeneCombination", "id": "1077" }, { "type": "GeneCombination", "id": "1082" }, { "type": "GeneCombination", "id": "1085" }, { "type": "GeneCombination", "id": "1089" }, { "type": "GeneCombination", "id": "1099" }, { "type": "GeneCombination", "id": "1103" }, { "type": "GeneCombination", "id": "1123" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GHR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GHR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GHR/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 2 } }