Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/871/genes/?format=api
{ "data": [ { "type": "Gene", "id": "MTOR", "attributes": { "go_molecular_function": [ "['protein kinase activity', 'RNA polymerase III type 1 promoter sequence-specific DNA binding', 'identical protein binding', 'protein serine/threonine kinase activity', 'TFIIIC-class transcription factor complex binding', 'ATP binding', 'protein serine kinase activity', 'phosphoprotein binding', 'kinase activity', 'RNA polymerase III type 2 promoter sequence-specific DNA binding', 'protein binding', 'ribosome binding', 'RNA polymerase III type 3 promoter sequence-specific DNA binding', 'protein serine/threonine/tyrosine kinase activity']" ], "pathway_id": [ "kegg_path:hsa01521", "kegg_path:hsa01522", "kegg_path:hsa04012", "kegg_path:hsa04066", "kegg_path:hsa04072", "kegg_path:hsa04136", "kegg_path:hsa04140", "kegg_path:hsa04150", "kegg_path:hsa04151", "kegg_path:hsa04152", "kegg_path:hsa04211", "kegg_path:hsa04213", "kegg_path:hsa04218", "kegg_path:hsa04371", "kegg_path:hsa04613", "kegg_path:hsa04630", "kegg_path:hsa04659", "kegg_path:hsa04714", "kegg_path:hsa04910", "kegg_path:hsa04919", "kegg_path:hsa04920", "kegg_path:hsa04930", "kegg_path:hsa04931", "kegg_path:hsa04935", "kegg_path:hsa05010", "kegg_path:hsa05014", "kegg_path:hsa05016", "kegg_path:hsa05017", "kegg_path:hsa05022", "kegg_path:hsa05131", "kegg_path:hsa05163", "kegg_path:hsa05165", "kegg_path:hsa05167", "kegg_path:hsa05168", "kegg_path:hsa05170", "kegg_path:hsa05200", "kegg_path:hsa05205", "kegg_path:hsa05206", "kegg_path:hsa05210", "kegg_path:hsa05212", "kegg_path:hsa05214", "kegg_path:hsa05215", "kegg_path:hsa05221", "kegg_path:hsa05224", "kegg_path:hsa05225", "kegg_path:hsa05226", "kegg_path:hsa05230", "kegg_path:hsa05231", "kegg_path:hsa05235", "R-HSA-1257604", "R-HSA-1280218", "R-HSA-162582", "R-HSA-1632852", "R-HSA-1643685", "R-HSA-165159", "R-HSA-166208", "R-HSA-168256", "R-HSA-194138", "R-HSA-212436", "R-HSA-2219528", "R-HSA-2262752", "R-HSA-3371556", "R-HSA-3371571", "R-HSA-3700989", "R-HSA-380972", "R-HSA-388841", "R-HSA-389356", "R-HSA-389357", "R-HSA-4420097", "R-HSA-5218920", "R-HSA-5628897", "R-HSA-5633007", "R-HSA-5663202", "R-HSA-5674400", "R-HSA-6804757", "R-HSA-6806003", "R-HSA-6807070", "R-HSA-73857", "R-HSA-74160", "R-HSA-8943724", "R-HSA-8953897", "R-HSA-9006925", "R-HSA-9006934", "R-HSA-9612973", "R-HSA-9639288" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P42345", "ensembl_id": "None", "entrez_id": "ENSG00000198793", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.474959" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "1881" }, { "type": "SmallVariant", "id": "1913" }, { "type": "SmallVariant", "id": "1959" }, { "type": "SmallVariant", "id": "2621" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MTOR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MTOR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "626" }, { "type": "GeneCombination", "id": "643" }, { "type": "GeneCombination", "id": "669" }, { "type": "GeneCombination", "id": "871" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MTOR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MTOR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MTOR/?format=api" } }, { "type": "Gene", "id": "NOBOX", "attributes": { "go_molecular_function": [ "['DNA-binding transcription factor activity, RNA polymerase II-specific', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'sequence-specific DNA binding']" ], "pathway_id": [], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "O60393", "ensembl_id": "None", "entrez_id": "ENSG00000106410", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:44.865997" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "2622" }, { "type": "SmallVariant", "id": "192" }, { "type": "SmallVariant", "id": "193" }, { "type": "SmallVariant", "id": "2268" }, { "type": "SmallVariant", "id": "2323" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NOBOX/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NOBOX/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "68" }, { "type": "GeneCombination", "id": "70" }, { "type": "GeneCombination", "id": "763" }, { "type": "GeneCombination", "id": "781" }, { "type": "GeneCombination", "id": "871" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NOBOX/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NOBOX/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NOBOX/?format=api" } }, { "type": "Gene", "id": "VEGFA", "attributes": { "go_molecular_function": [ "['vascular endothelial growth factor receptor 2 binding', 'extracellular matrix binding', 'fibronectin binding', 'protein homodimerization activity', 'growth factor activity', 'vascular endothelial growth factor receptor 1 binding', 'vascular endothelial growth factor receptor binding', 'protein binding', 'platelet-derived growth factor receptor binding', 'heparin binding', 'receptor ligand activity', 'chemoattractant activity', 'identical protein binding', 'cytokine activity']" ], "pathway_id": [ "kegg_path:hsa01521", "kegg_path:hsa04010", "kegg_path:hsa04014", "kegg_path:hsa04015", "kegg_path:hsa04020", "kegg_path:hsa04066", "kegg_path:hsa04151", "kegg_path:hsa04370", "kegg_path:hsa04510", "kegg_path:hsa04926", "kegg_path:hsa04933", "kegg_path:hsa05163", "kegg_path:hsa05165", "kegg_path:hsa05167", "kegg_path:hsa05200", "kegg_path:hsa05205", "kegg_path:hsa05206", "kegg_path:hsa05211", "kegg_path:hsa05212", "kegg_path:hsa05219", "kegg_path:hsa05323", "kegg_path:hsa05418", "R-HSA-109582", "R-HSA-114608", "R-HSA-1234158", "R-HSA-1234174", "R-HSA-1280215", "R-HSA-162582", "R-HSA-168256", "R-HSA-194138", "R-HSA-194313", "R-HSA-195399", "R-HSA-212436", "R-HSA-2262752", "R-HSA-449147", "R-HSA-6785807", "R-HSA-73857", "R-HSA-74160", "R-HSA-76002", "R-HSA-76005", "R-HSA-8864260", "R-HSA-8866910", "R-HSA-8953897", "R-HSA-9006934" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "J3KPA4", "ensembl_id": "None", "entrez_id": "ENSG00000112715", "chromosome_number": "6", "lastmodified": "2023-05-16T12:02:32.427835" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "2623" }, { "type": "SmallVariant", "id": "3354" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/VEGFA/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/VEGFA/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "871" }, { "type": "GeneCombination", "id": "1128" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/VEGFA/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/VEGFA/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/VEGFA/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2026 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }