Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/550/genes/?format=api
{ "data": [ { "type": "Gene", "id": "AHCY", "attributes": { "go_molecular_function": [ "protein binding", "hydrolase activity", "adenosylhomocysteinase activity" ], "pathway_id": [ "R-HSA-156581", "kegg_path:hsa01100", "R-HSA-211859", "R-HSA-71291", "R-HSA-1614635", "R-HSA-156580", "R-HSA-1430728", "R-HSA-2408508", "R-HSA-5668914", "kegg_path:hsa00270", "R-HSA-1643685", "R-HSA-5579029", "R-HSA-2408522", "R-HSA-5578997" ], "essential_gene": null, "status": "CU", "uniprot_acc": "P23526", "ensembl_id": "ENSG00000101444", "entrez_id": "191", "chromosome_number": "20", "lastmodified": "2021-10-18T11:00:44.451871" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1615" }, { "type": "SmallVariant", "id": "1687" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AHCY/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AHCY/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "519" }, { "type": "GeneCombination", "id": "550" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AHCY/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AHCY/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/AHCY/?format=api" } }, { "type": "Gene", "id": "AMBRA1", "attributes": { "go_molecular_function": [ "ubiquitin protein ligase binding", "protein binding" ], "pathway_id": [ "kegg_path:hsa05022", "kegg_path:hsa05017", "kegg_path:hsa04137", "kegg_path:hsa05014", "kegg_path:hsa04140", "kegg_path:hsa05016", "kegg_path:hsa05010", "R-HSA-9612973", "R-HSA-1632852" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9C0C7", "ensembl_id": "ENSG00000110497", "entrez_id": "55626", "chromosome_number": "11", "lastmodified": "2021-10-18T11:00:44.345337" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1686" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AMBRA1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AMBRA1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "550" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AMBRA1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AMBRA1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/AMBRA1/?format=api" } }, { "type": "Gene", "id": "CXCL6", "attributes": { "go_molecular_function": [ "cytokine activity", "chemokine activity", "heparin binding", "CXCR chemokine receptor binding" ], "pathway_id": [ "kegg_path:hsa04061", "kegg_path:hsa04668", "R-HSA-373076", "R-HSA-418594", "kegg_path:hsa04062", "kegg_path:hsa05323", "R-HSA-162582", "R-HSA-372790", "R-HSA-380108", "kegg_path:hsa04060", "kegg_path:hsa04657", "R-HSA-500792", "kegg_path:hsa05133", "R-HSA-388396", "R-HSA-375276" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P80162", "ensembl_id": "ENSG00000124875", "entrez_id": "6372", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:44.627345" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1503" }, { "type": "SmallVariant", "id": "1571" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CXCL6/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CXCL6/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "482" }, { "type": "GeneCombination", "id": "505" }, { "type": "GeneCombination", "id": "550" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CXCL6/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CXCL6/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CXCL6/?format=api" } }, { "type": "Gene", "id": "INVS", "attributes": { "go_molecular_function": [ "protein binding", "calmodulin binding" ], "pathway_id": [ "kegg_path:hsa04310", "kegg_path:hsa04310" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9Y283", "ensembl_id": "ENSG00000119509", "entrez_id": "27130", "chromosome_number": "9", "lastmodified": "2021-10-18T11:00:44.619381" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "416" }, { "type": "SmallVariant", "id": "1499" }, { "type": "SmallVariant", "id": "1593" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/INVS/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/INVS/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "140" }, { "type": "GeneCombination", "id": "480" }, { "type": "GeneCombination", "id": "512" }, { "type": "GeneCombination", "id": "525" }, { "type": "GeneCombination", "id": "550" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/INVS/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/INVS/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/INVS/?format=api" } }, { "type": "Gene", "id": "PRICKLE2", "attributes": { "go_molecular_function": [ "zinc ion binding", "metal ion binding" ], "pathway_id": [ "kegg_path:hsa04310", "kegg_path:hsa04310" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "A0A1X7SBR1", "ensembl_id": "ENSG00000163637", "entrez_id": "166336", "chromosome_number": "3", "lastmodified": "2021-10-18T11:00:44.726386" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1688" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PRICKLE2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PRICKLE2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "550" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PRICKLE2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PRICKLE2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PRICKLE2/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 5 } }