Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1102/genes/?format=api
{ "data": [ { "type": "Gene", "id": "FGFR3", "attributes": { "go_molecular_function": [ "['protein tyrosine kinase activity', 'protein serine/threonine/tyrosine kinase activity', 'transmembrane receptor protein tyrosine kinase activity', 'protein binding', 'fibroblast growth factor-activated receptor activity', 'fibroblast growth factor binding', 'identical protein binding', 'ATP binding']" ], "pathway_id": [ "kegg_path:hsa01521", "kegg_path:hsa04010", "kegg_path:hsa04014", "kegg_path:hsa04015", "kegg_path:hsa04020", "kegg_path:hsa04144", "kegg_path:hsa04151", "kegg_path:hsa04550", "kegg_path:hsa04810", "kegg_path:hsa05200", "kegg_path:hsa05206", "kegg_path:hsa05219", "kegg_path:hsa05230", "R-HSA-1226099", "R-HSA-1643685", "R-HSA-1839130", "R-HSA-2033514", "R-HSA-2033515", "R-HSA-5655332", "R-HSA-5663202", "R-HSA-8853334", "R-HSA-8853338", "kegg_path:hsa01521", "kegg_path:hsa04010", "kegg_path:hsa04014", "kegg_path:hsa04015", "kegg_path:hsa04020", "kegg_path:hsa04144", "kegg_path:hsa04151", "kegg_path:hsa04550", "kegg_path:hsa04810", "kegg_path:hsa05200", "kegg_path:hsa05206", "kegg_path:hsa05219", "kegg_path:hsa05230" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P22607", "ensembl_id": "None", "entrez_id": "ENSG00000068078", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:44.500473" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "1152" }, { "type": "SmallVariant", "id": "3209" }, { "type": "SmallVariant", "id": "3276" }, { "type": "SmallVariant", "id": "3333" }, { "type": "SmallVariant", "id": "3700" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FGFR3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FGFR3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "369" }, { "type": "GeneCombination", "id": "1072" }, { "type": "GeneCombination", "id": "1082" }, { "type": "GeneCombination", "id": "1102" }, { "type": "GeneCombination", "id": "1124" }, { "type": "GeneCombination", "id": "1252" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FGFR3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FGFR3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FGFR3/?format=api" } }, { "type": "Gene", "id": "FLNA", "attributes": { "go_molecular_function": [ "['RNA binding', 'Fc-gamma receptor I complex binding', 'small GTPase binding', 'actin filament binding', 'protein kinase C binding', 'transmembrane transporter binding', 'cadherin binding', 'potassium channel regulator activity', 'kinase binding', 'G protein-coupled receptor binding', 'protein binding', 'GTPase binding', 'protein homodimerization activity', 'DNA-binding transcription factor binding']" ], "pathway_id": [ "kegg_path:hsa04010", "kegg_path:hsa04510", "kegg_path:hsa05132", "kegg_path:hsa05205", "R-HSA-109582", "R-HSA-114608", "R-HSA-1169410", "R-HSA-1280215", "R-HSA-1500931", "R-HSA-162582", "R-HSA-168256", "R-HSA-194315", "R-HSA-195258", "R-HSA-430116", "R-HSA-446353", "R-HSA-446728", "R-HSA-5627123", "R-HSA-76002", "R-HSA-76005", "R-HSA-8983711", "R-HSA-913531", "kegg_path:hsa04010", "kegg_path:hsa04510", "kegg_path:hsa05132", "kegg_path:hsa05205", "kegg_path:hsa04010", "kegg_path:hsa04510", "kegg_path:hsa05132", "kegg_path:hsa05205", "kegg_path:hsa04010", "kegg_path:hsa04510", "kegg_path:hsa05132", "kegg_path:hsa05205", "R-HSA-109582", "R-HSA-114608", "R-HSA-1169410", "R-HSA-1280215", "R-HSA-1500931", "R-HSA-162582", "R-HSA-168256", "R-HSA-194315", "R-HSA-195258", "R-HSA-430116", "R-HSA-446353", "R-HSA-446728", "R-HSA-5627123", "R-HSA-76002", "R-HSA-76005", "R-HSA-8983711", "R-HSA-913531", "kegg_path:hsa04010", "kegg_path:hsa04510", "kegg_path:hsa05132", "kegg_path:hsa05205", "kegg_path:hsa04010", "kegg_path:hsa04510", "kegg_path:hsa05132", "kegg_path:hsa05205" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P21333", "ensembl_id": "None", "entrez_id": "ENSG00000196924", "chromosome_number": "X", "lastmodified": "2021-10-18T11:00:44.390873" }, "relationships": { "variant_set": { "meta": { "count": 6 }, "data": [ { "type": "SmallVariant", "id": "767" }, { "type": "SmallVariant", "id": "1298" }, { "type": "SmallVariant", "id": "3177" }, { "type": "SmallVariant", "id": "3241" }, { "type": "SmallVariant", "id": "3277" }, { "type": "SmallVariant", "id": "3314" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FLNA/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FLNA/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "240" }, { "type": "GeneCombination", "id": "410" }, { "type": "GeneCombination", "id": "1061" }, { "type": "GeneCombination", "id": "1086" }, { "type": "GeneCombination", "id": "1102" }, { "type": "GeneCombination", "id": "1114" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FLNA/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FLNA/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FLNA/?format=api" } }, { "type": "Gene", "id": "GLI2", "attributes": { "go_molecular_function": [ "['zinc ion binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'sequence-specific double-stranded DNA binding', 'sequence-specific DNA binding', 'protein binding', 'DNA-binding transcription factor activity', 'promoter-specific chromatin binding', 'DNA-binding transcription factor activity, RNA polymerase II-specific']" ], "pathway_id": [ "kegg_path:hsa04340", "kegg_path:hsa04390", "kegg_path:hsa05200", "kegg_path:hsa05217", "R-HSA-162582", "R-HSA-212436", "R-HSA-5358351", "R-HSA-5610783", "R-HSA-5610787", "R-HSA-5632684", "R-HSA-5635851", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878166", "R-HSA-8941284", "R-HSA-8941326", "kegg_path:hsa04340", "kegg_path:hsa04390", "kegg_path:hsa05200", "kegg_path:hsa05217" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P10070", "ensembl_id": "None", "entrez_id": "ENSG00000074047", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.515380" }, "relationships": { "variant_set": { "meta": { "count": 14 }, "data": [ { "type": "SmallVariant", "id": "725" }, { "type": "SmallVariant", "id": "735" }, { "type": "SmallVariant", "id": "1217" }, { "type": "SmallVariant", "id": "1281" }, { "type": "SmallVariant", "id": "2493" }, { "type": "SmallVariant", "id": "2512" }, { "type": "SmallVariant", "id": "2514" }, { "type": "SmallVariant", "id": "3164" }, { "type": "SmallVariant", "id": "3199" }, { "type": "SmallVariant", "id": "3201" }, { "type": "SmallVariant", "id": "3213" }, { "type": "SmallVariant", "id": "3229" }, { "type": "SmallVariant", "id": "3265" }, { "type": "SmallVariant", "id": "3487" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GLI2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GLI2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 16 }, "data": [ { "type": "GeneCombination", "id": "232" }, { "type": "GeneCombination", "id": "235" }, { "type": "GeneCombination", "id": "407" }, { "type": "GeneCombination", "id": "387" }, { "type": "GeneCombination", "id": "844" }, { "type": "GeneCombination", "id": "852" }, { "type": "GeneCombination", "id": "853" }, { "type": "GeneCombination", "id": "1056" }, { "type": "GeneCombination", "id": "1068" }, { "type": "GeneCombination", "id": "1069" }, { "type": "GeneCombination", "id": "1081" }, { "type": "GeneCombination", "id": "1098" }, { "type": "GeneCombination", "id": "1102" }, { "type": "GeneCombination", "id": "1173" }, { "type": "GeneCombination", "id": "1074" }, { "type": "GeneCombination", "id": "1253" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GLI2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GLI2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GLI2/?format=api" } }, { "type": "Gene", "id": "GPRC6A", "attributes": { "go_molecular_function": [ "['G protein-coupled receptor activity']" ], "pathway_id": [ "kegg_path:hsa04621", "R-HSA-162582", "R-HSA-372790", "R-HSA-388396", "R-HSA-416476", "R-HSA-420499", "R-HSA-500792" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q5T6X5", "ensembl_id": "None", "entrez_id": "ENSG00000173612", "chromosome_number": "6", "lastmodified": "2023-05-16T12:02:33.486621" }, "relationships": { "variant_set": { "meta": { "count": 7 }, "data": [ { "type": "SmallVariant", "id": "3157" }, { "type": "SmallVariant", "id": "3183" }, { "type": "SmallVariant", "id": "3186" }, { "type": "SmallVariant", "id": "3202" }, { "type": "SmallVariant", "id": "3204" }, { "type": "SmallVariant", "id": "3239" }, { "type": "SmallVariant", "id": "3312" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GPRC6A/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GPRC6A/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 11 }, "data": [ { "type": "GeneCombination", "id": "1053" }, { "type": "GeneCombination", "id": "1063" }, { "type": "GeneCombination", "id": "1064" }, { "type": "GeneCombination", "id": "1069" }, { "type": "GeneCombination", "id": "1070" }, { "type": "GeneCombination", "id": "1085" }, { "type": "GeneCombination", "id": "1102" }, { "type": "GeneCombination", "id": "1105" }, { "type": "GeneCombination", "id": "1107" }, { "type": "GeneCombination", "id": "1111" }, { "type": "GeneCombination", "id": "1114" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GPRC6A/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GPRC6A/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GPRC6A/?format=api" } }, { "type": "Gene", "id": "NR5A1", "attributes": { "go_molecular_function": [ "['DNA binding', 'chromatin binding', 'zinc ion binding', 'enzyme binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'sequence-specific double-stranded DNA binding', 'nuclear receptor activity', 'protein binding', 'RNA polymerase II transcription regulatory region sequence-specific DNA binding', 'sequence-specific DNA binding', 'phospholipid binding', 'transcription coregulator binding', 'DNA-binding transcription factor activity, RNA polymerase II-specific']" ], "pathway_id": [ "kegg_path:hsa04927", "kegg_path:hsa04934", "kegg_path:hsa04927", "kegg_path:hsa04934", "R-HSA-1266738", "R-HSA-212436", "R-HSA-2990846", "R-HSA-3108232", "R-HSA-383280", "R-HSA-392499", "R-HSA-4090294", "R-HSA-452723", "R-HSA-597592", "R-HSA-73857", "R-HSA-74160", "R-HSA-9690406" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q13285", "ensembl_id": "None", "entrez_id": "ENSG00000136931", "chromosome_number": "9", "lastmodified": "2021-10-18T11:00:44.221369" }, "relationships": { "variant_set": { "meta": { "count": 19 }, "data": [ { "type": "SmallVariant", "id": "861" }, { "type": "SmallVariant", "id": "863" }, { "type": "SmallVariant", "id": "1197" }, { "type": "SmallVariant", "id": "1199" }, { "type": "SmallVariant", "id": "1206" }, { "type": "SmallVariant", "id": "1214" }, { "type": "SmallVariant", "id": "1442" }, { "type": "SmallVariant", "id": "1445" }, { "type": "SmallVariant", "id": "1697" }, { "type": "SmallVariant", "id": "2169" }, { "type": "SmallVariant", "id": "2269" }, { "type": "SmallVariant", "id": "2278" }, { "type": "SmallVariant", "id": "3160" }, { "type": "SmallVariant", "id": "3257" }, { "type": "SmallVariant", "id": "3272" }, { "type": "SmallVariant", "id": "3275" }, { "type": "SmallVariant", "id": "3411" }, { "type": "SmallVariant", "id": "3413" }, { "type": "SmallVariant", "id": "3667" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NR5A1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NR5A1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 18 }, "data": [ { "type": "GeneCombination", "id": "268" }, { "type": "GeneCombination", "id": "267" }, { "type": "GeneCombination", "id": "384" }, { "type": "GeneCombination", "id": "385" }, { "type": "GeneCombination", "id": "386" }, { "type": "GeneCombination", "id": "387" }, { "type": "GeneCombination", "id": "459" }, { "type": "GeneCombination", "id": "460" }, { "type": "GeneCombination", "id": "554" }, { "type": "GeneCombination", "id": "738" }, { "type": "GeneCombination", "id": "766" }, { "type": "GeneCombination", "id": "763" }, { "type": "GeneCombination", "id": "1055" }, { "type": "GeneCombination", "id": "1094" }, { "type": "GeneCombination", "id": "1101" }, { "type": "GeneCombination", "id": "1102" }, { "type": "GeneCombination", "id": "1144" }, { "type": "GeneCombination", "id": "1235" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NR5A1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NR5A1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NR5A1/?format=api" } }, { "type": "Gene", "id": "PROKR2", "attributes": { "go_molecular_function": [ "['neuropeptide Y receptor activity', 'protein binding', 'G protein-coupled receptor activity']" ], "pathway_id": [ "R-HSA-162582", "R-HSA-372790", "R-HSA-373076", "R-HSA-375276", "R-HSA-388396", "R-HSA-416476", "R-HSA-500792" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "None", "ensembl_id": "None", "entrez_id": "ENSG00000101292", "chromosome_number": "20", "lastmodified": "2021-10-18T11:00:44.395103" }, "relationships": { "variant_set": { "meta": { "count": 38 }, "data": [ { "type": "SmallVariant", "id": "26" }, { "type": "SmallVariant", "id": "78" }, { "type": "SmallVariant", "id": "331" }, { "type": "SmallVariant", "id": "383" }, { "type": "SmallVariant", "id": "397" }, { "type": "SmallVariant", "id": "400" }, { "type": "SmallVariant", "id": "402" }, { "type": "SmallVariant", "id": "857" }, { "type": "SmallVariant", "id": "1057" }, { "type": "SmallVariant", "id": "1798" }, { "type": "SmallVariant", "id": "1825" }, { "type": "SmallVariant", "id": "1826" }, { "type": "SmallVariant", "id": "1857" }, { "type": "SmallVariant", "id": "1864" }, { "type": "SmallVariant", "id": "1888" }, { "type": "SmallVariant", "id": "1892" }, { "type": "SmallVariant", "id": "1898" }, { "type": "SmallVariant", "id": "1901" }, { "type": "SmallVariant", "id": "1931" }, { "type": "SmallVariant", "id": "2398" }, { "type": "SmallVariant", "id": "2399" }, { "type": "SmallVariant", "id": "2502" }, { "type": "SmallVariant", "id": "2513" }, { "type": "SmallVariant", "id": "2517" }, { "type": "SmallVariant", "id": "2577" }, { "type": "SmallVariant", "id": "2579" }, { "type": "SmallVariant", "id": "2662" }, { "type": "SmallVariant", "id": "2678" }, { "type": "SmallVariant", "id": "2691" }, { "type": "SmallVariant", "id": "2696" }, { "type": "SmallVariant", "id": "2699" }, { "type": "SmallVariant", "id": "2719" }, { "type": "SmallVariant", "id": "2721" }, { "type": "SmallVariant", "id": "2725" }, { "type": "SmallVariant", "id": "2768" }, { "type": "SmallVariant", "id": "2829" }, { "type": "SmallVariant", "id": "2831" }, { "type": "SmallVariant", "id": "3175" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PROKR2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PROKR2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 52 }, "data": [ { "type": "GeneCombination", "id": "10" }, { "type": "GeneCombination", "id": "31" }, { "type": "GeneCombination", "id": "116" }, { "type": "GeneCombination", "id": "265" }, { "type": "GeneCombination", "id": "257" }, { "type": "GeneCombination", "id": "442" }, { "type": "GeneCombination", "id": "478" }, { "type": "GeneCombination", "id": "596" }, { "type": "GeneCombination", "id": "616" }, { "type": "GeneCombination", "id": "617" }, { "type": "GeneCombination", "id": "619" }, { "type": "GeneCombination", "id": "622" }, { "type": "GeneCombination", "id": "626" }, { "type": "GeneCombination", "id": "629" }, { "type": "GeneCombination", "id": "630" }, { "type": "GeneCombination", "id": "631" }, { "type": "GeneCombination", "id": "632" }, { "type": "GeneCombination", "id": "637" }, { "type": "GeneCombination", "id": "653" }, { "type": "GeneCombination", "id": "656" }, { "type": "GeneCombination", "id": "662" }, { "type": "GeneCombination", "id": "663" }, { "type": "GeneCombination", "id": "817" }, { "type": "GeneCombination", "id": "852" }, { "type": "GeneCombination", "id": "854" }, { "type": "GeneCombination", "id": 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Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 6 } }