Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/396/genes/?format=api
{ "data": [ { "type": "Gene", "id": "GLIS3", "attributes": { "go_molecular_function": [ "['RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'DNA-binding transcription activator activity, RNA polymerase II-specific', 'DNA-binding transcription factor activity, RNA polymerase II-specific', 'protein binding', 'metal ion binding', 'DNA-binding transcription repressor activity, RNA polymerase II-specific']" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q8NEA6", "ensembl_id": "None", "entrez_id": "ENSG00000107249", "chromosome_number": "9", "lastmodified": "2021-10-18T11:00:44.803335" }, "relationships": { "variant_set": { "meta": { "count": 10 }, "data": [ { "type": "SmallVariant", "id": "1016" }, { "type": "SmallVariant", "id": "1233" }, { "type": "SmallVariant", "id": "1235" }, { "type": "SmallVariant", "id": "1236" }, { "type": "SmallVariant", "id": "1242" }, { "type": "SmallVariant", "id": "1259" }, { "type": "SmallVariant", "id": "1265" }, { "type": "SmallVariant", "id": "2352" }, { "type": "SmallVariant", "id": "3129" }, { "type": "SmallVariant", "id": "3146" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GLIS3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GLIS3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 8 }, "data": [ { "type": "GeneCombination", "id": "325" }, { "type": "GeneCombination", "id": "393" }, { "type": "GeneCombination", "id": "394" }, { "type": "GeneCombination", "id": "396" }, { "type": "GeneCombination", "id": "401" }, { "type": "GeneCombination", "id": "403" }, { "type": "GeneCombination", "id": "794" }, { "type": "GeneCombination", "id": "1046" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GLIS3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GLIS3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GLIS3/?format=api" } }, { "type": "Gene", "id": "SLC26A4", "attributes": { "go_molecular_function": [ "['oxalate transmembrane transporter activity', 'chloride transmembrane transporter activity', 'bicarbonate transmembrane transporter activity', 'anion:anion antiporter activity', 'iodide transmembrane transporter activity', 'sulfate transmembrane transporter activity', 'secondary active sulfate transmembrane transporter activity']" ], "pathway_id": [ "kegg_path:hsa04918", "R-HSA-1643685", "R-HSA-382551", "R-HSA-425393", "R-HSA-425407", "R-HSA-427601", "R-HSA-5619046", "R-HSA-5619102", "R-HSA-5619115" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "None", "ensembl_id": "None", "entrez_id": "ENSG00000091137", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:44.816775" }, "relationships": { "variant_set": { "meta": { "count": 16 }, "data": [ { "type": "SmallVariant", "id": "1257" }, { "type": "SmallVariant", "id": "471" }, { "type": "SmallVariant", "id": "473" }, { "type": "SmallVariant", "id": "612" }, { "type": "SmallVariant", "id": "614" }, { "type": "SmallVariant", "id": "997" }, { "type": "SmallVariant", "id": "1017" }, { "type": "SmallVariant", "id": "1066" }, { "type": "SmallVariant", "id": "1182" }, { "type": "SmallVariant", "id": "1243" }, { "type": "SmallVariant", "id": "1244" }, { "type": "SmallVariant", "id": "1254" }, { "type": "SmallVariant", "id": "1266" }, { "type": "SmallVariant", "id": "2034" }, { "type": "SmallVariant", "id": "2350" }, { "type": "SmallVariant", "id": "2389" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SLC26A4/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SLC26A4/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 18 }, "data": [ { "type": "GeneCombination", "id": "157" }, { "type": "GeneCombination", "id": "209" }, { "type": "GeneCombination", "id": "318" }, { "type": "GeneCombination", "id": "319" }, { "type": "GeneCombination", "id": "348" }, { "type": "GeneCombination", "id": "379" }, { "type": "GeneCombination", "id": "396" }, { "type": "GeneCombination", "id": "397" }, { "type": "GeneCombination", "id": "400" }, { "type": "GeneCombination", "id": "403" }, { "type": "GeneCombination", "id": "404" }, { "type": "GeneCombination", "id": "813" }, { "type": "GeneCombination", "id": "812" }, { "type": "GeneCombination", "id": "810" }, { "type": "GeneCombination", "id": "855" }, { "type": "GeneCombination", "id": "1048" }, { "type": "GeneCombination", "id": "793" }, { "type": "GeneCombination", "id": "801" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SLC26A4/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SLC26A4/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SLC26A4/?format=api" } }, { "type": "Gene", "id": "TSHR", "attributes": { "go_molecular_function": [ "['signaling receptor activity', 'thyroid-stimulating hormone receptor activity', 'protein binding', 'G protein-coupled peptide receptor activity', 'protein-containing complex binding']" ], "pathway_id": [ "kegg_path:hsa04024", "kegg_path:hsa04080", "kegg_path:hsa04918", "kegg_path:hsa04923", "kegg_path:hsa05320", "kegg_path:hsa04024", "kegg_path:hsa04080", "kegg_path:hsa04918", "kegg_path:hsa04923", "kegg_path:hsa05320", "R-HSA-162582", "R-HSA-1643685", "R-HSA-372790", "R-HSA-373076", "R-HSA-375281", "R-HSA-388396", "R-HSA-418555", "R-HSA-500792", "R-HSA-5663205", "R-HSA-9658195", "R-HSA-9660821", "R-HSA-9662851", "R-HSA-9664433" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "A0A0A0MTJ0", "ensembl_id": "None", "entrez_id": "ENSG00000165409", "chromosome_number": "14", "lastmodified": "2021-10-18T11:00:44.615399" }, "relationships": { "variant_set": { "meta": { "count": 23 }, "data": [ { "type": "SmallVariant", "id": "2144" }, { "type": "SmallVariant", "id": "1013" }, { "type": "SmallVariant", "id": "1014" }, { "type": "SmallVariant", "id": "1099" }, { "type": "SmallVariant", "id": "1103" }, { "type": "SmallVariant", "id": "1230" }, { "type": "SmallVariant", "id": "1240" }, { "type": "SmallVariant", "id": "1241" }, { "type": "SmallVariant", "id": "1245" }, { "type": "SmallVariant", "id": "1250" }, { "type": "SmallVariant", "id": "2142" }, { "type": "SmallVariant", "id": "2146" }, { "type": "SmallVariant", "id": "2346" }, { "type": "SmallVariant", "id": "2348" }, { "type": "SmallVariant", "id": "2351" }, { "type": "SmallVariant", "id": "2360" }, { "type": "SmallVariant", "id": "3121" }, { "type": "SmallVariant", "id": "3122" }, { "type": "SmallVariant", "id": "3124" }, { "type": "SmallVariant", "id": "3127" }, { "type": "SmallVariant", "id": "3141" }, { "type": "SmallVariant", "id": "3143" }, { "type": "SmallVariant", "id": "3145" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TSHR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TSHR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 10 }, "data": [ { "type": "GeneCombination", "id": "324" }, { "type": "GeneCombination", "id": "360" }, { "type": "GeneCombination", "id": "392" }, { "type": "GeneCombination", "id": "396" }, { "type": "GeneCombination", "id": "397" }, { "type": "GeneCombination", "id": "399" }, { "type": "GeneCombination", "id": "856" }, { "type": "GeneCombination", "id": "359" }, { "type": "GeneCombination", "id": "793" }, { "type": "GeneCombination", "id": "798" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TSHR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TSHR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/TSHR/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }