Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/616/genes/?format=api
{ "data": [ { "type": "Gene", "id": "PNPLA6", "attributes": { "go_molecular_function": [ "['lysophospholipase activity', 'phosphatidyl phospholipase B activity']" ], "pathway_id": [ "kegg_path:hsa00564", "R-HSA-1430728", "R-HSA-1483255", "R-HSA-1483257", "R-HSA-556833", "R-HSA-6814848" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q8IY17", "ensembl_id": "None", "entrez_id": "ENSG00000032444", "chromosome_number": "19", "lastmodified": "2021-10-18T11:00:44.696531" }, "relationships": { "variant_set": { "meta": { "count": 8 }, "data": [ { "type": "SmallVariant", "id": "1794" }, { "type": "SmallVariant", "id": "1855" }, { "type": "SmallVariant", "id": "2773" }, { "type": "SmallVariant", "id": "2918" }, { "type": "SmallVariant", "id": "2939" }, { "type": "SmallVariant", "id": "2968" }, { "type": "SmallVariant", "id": "2972" }, { "type": "SmallVariant", "id": "2979" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PNPLA6/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PNPLA6/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 9 }, "data": [ { "type": "GeneCombination", "id": "594" }, { "type": "GeneCombination", "id": "616" }, { "type": "GeneCombination", "id": "927" }, { "type": "GeneCombination", "id": "968" }, { "type": "GeneCombination", "id": "977" }, { "type": "GeneCombination", "id": "988" }, { "type": "GeneCombination", "id": "990" }, { "type": "GeneCombination", "id": "994" }, { "type": "GeneCombination", "id": "997" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PNPLA6/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PNPLA6/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PNPLA6/?format=api" } }, { "type": "Gene", "id": "POLR3A", "attributes": { "go_molecular_function": [ "['DNA binding', 'chromatin binding', 'metal ion binding', \"DNA-directed 5'-3' RNA polymerase activity\"]" ], "pathway_id": [ "kegg_path:hsa03020", "kegg_path:hsa04623", "R-HSA-168249", "R-HSA-168256", "R-HSA-1834949", "R-HSA-73780", "R-HSA-73980", "R-HSA-74158", "R-HSA-74160", "R-HSA-749476", "R-HSA-76046", "R-HSA-76061", "R-HSA-76066", "R-HSA-76071" ], "essential_gene": null, "status": "CU", "uniprot_acc": "O14802", "ensembl_id": "None", "entrez_id": "ENSG00000148606", "chromosome_number": "10", "lastmodified": "2021-10-18T11:00:44.815827" }, "relationships": { "variant_set": { "meta": { "count": 6 }, "data": [ { "type": "SmallVariant", "id": "38" }, { "type": "SmallVariant", "id": "1422" }, { "type": "SmallVariant", "id": "1792" }, { "type": "SmallVariant", "id": "1854" }, { "type": "SmallVariant", "id": "2781" }, { "type": "SmallVariant", "id": "2888" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/POLR3A/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/POLR3A/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "15" }, { "type": "GeneCombination", "id": "447" }, { "type": "GeneCombination", "id": "593" }, { "type": "GeneCombination", "id": "616" }, { "type": "GeneCombination", "id": "930" }, { "type": "GeneCombination", "id": "956" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/POLR3A/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/POLR3A/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/POLR3A/?format=api" } }, { "type": "Gene", "id": "PROKR2", "attributes": { "go_molecular_function": [ "['neuropeptide Y receptor activity', 'protein binding', 'G protein-coupled receptor activity']" ], "pathway_id": [ "R-HSA-162582", "R-HSA-372790", "R-HSA-373076", "R-HSA-375276", "R-HSA-388396", "R-HSA-416476", "R-HSA-500792" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "None", "ensembl_id": "None", "entrez_id": "ENSG00000101292", "chromosome_number": "20", "lastmodified": "2021-10-18T11:00:44.395103" }, "relationships": { "variant_set": { "meta": { "count": 38 }, "data": [ { "type": "SmallVariant", "id": "26" }, { "type": "SmallVariant", "id": "78" }, { "type": "SmallVariant", "id": "331" }, { "type": "SmallVariant", "id": "383" }, { "type": "SmallVariant", "id": "397" }, { "type": "SmallVariant", "id": "400" }, { "type": "SmallVariant", "id": "402" }, { "type": "SmallVariant", "id": "857" }, { "type": "SmallVariant", "id": "1057" }, { "type": "SmallVariant", "id": "1798" }, { "type": "SmallVariant", "id": "1825" }, { "type": "SmallVariant", "id": "1826" }, { "type": "SmallVariant", "id": "1857" }, { "type": "SmallVariant", "id": "1864" }, { "type": "SmallVariant", "id": "1888" }, { "type": "SmallVariant", "id": "1892" }, { "type": "SmallVariant", "id": "1898" }, { "type": "SmallVariant", "id": "1901" }, { "type": "SmallVariant", "id": "1931" }, { "type": "SmallVariant", "id": "2398" }, { "type": "SmallVariant", "id": "2399" }, { "type": "SmallVariant", "id": "2502" }, { "type": "SmallVariant", "id": "2513" }, { "type": "SmallVariant", "id": "2517" }, { "type": "SmallVariant", "id": "2577" }, { "type": "SmallVariant", "id": "2579" }, { "type": "SmallVariant", "id": "2662" }, { "type": "SmallVariant", "id": "2678" }, { "type": "SmallVariant", "id": "2691" }, { "type": "SmallVariant", "id": "2696" }, { "type": "SmallVariant", "id": "2699" }, { "type": "SmallVariant", "id": "2719" }, { "type": "SmallVariant", "id": "2721" }, { "type": "SmallVariant", "id": "2725" }, { "type": "SmallVariant", "id": "2768" }, { "type": "SmallVariant", "id": "2829" }, { "type": "SmallVariant", "id": "2831" }, { "type": "SmallVariant", "id": "3175" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PROKR2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PROKR2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 52 }, "data": [ { "type": "GeneCombination", "id": "10" }, { "type": "GeneCombination", "id": "31" }, { "type": "GeneCombination", "id": "116" }, { "type": "GeneCombination", "id": "265" }, { "type": "GeneCombination", "id": "257" }, { "type": "GeneCombination", "id": "442" }, { "type": "GeneCombination", "id": "478" }, { "type": "GeneCombination", "id": "596" }, { "type": "GeneCombination", "id": "616" }, { "type": "GeneCombination", "id": "617" }, { "type": "GeneCombination", "id": "619" }, { "type": "GeneCombination", "id": "622" }, { "type": "GeneCombination", "id": "626" }, { "type": "GeneCombination", "id": "629" }, { "type": "GeneCombination", "id": "630" }, { "type": "GeneCombination", "id": "631" }, { "type": "GeneCombination", "id": "632" }, { "type": "GeneCombination", "id": "637" }, { "type": "GeneCombination", "id": "653" }, { "type": "GeneCombination", "id": "656" }, { "type": "GeneCombination", "id": "662" }, { "type": "GeneCombination", "id": "663" }, { "type": "GeneCombination", "id": "817" }, { "type": "GeneCombination", "id": "852" }, { "type": "GeneCombination", "id": "854" }, { "type": "GeneCombination", "id": "859" }, { "type": "GeneCombination", "id": "606" }, { "type": "GeneCombination", "id": "189" }, { "type": "GeneCombination", "id": "858" }, { "type": "GeneCombination", "id": "892" }, { "type": "GeneCombination", "id": "896" }, { "type": "GeneCombination", "id": "898" }, { "type": "GeneCombination", "id": "136" }, { "type": "GeneCombination", "id": "902" }, { "type": "GeneCombination", "id": "903" }, { "type": "GeneCombination", "id": "904" }, { "type": "GeneCombination", "id": "906" }, { "type": "GeneCombination", "id": "910" }, { "type": "GeneCombination", "id": "90" }, { "type": "GeneCombination", "id": "941" }, { "type": "GeneCombination", "id": "635" }, { "type": "GeneCombination", "id": "947" }, { "type": "GeneCombination", "id": "971" }, { "type": "GeneCombination", "id": "1061" }, { "type": "GeneCombination", "id": "1069" }, { "type": "GeneCombination", "id": "1080" }, { "type": "GeneCombination", "id": "1084" }, { "type": "GeneCombination", "id": "1088" }, { "type": "GeneCombination", "id": "1091" }, { "type": "GeneCombination", "id": "1092" }, { "type": "GeneCombination", "id": "1102" }, { "type": "GeneCombination", "id": "1111" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PROKR2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PROKR2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PROKR2/?format=api" } }, { "type": "Gene", "id": "TRAPPC9", "attributes": { "go_molecular_function": [ "protein binding" ], "pathway_id": [ "R-HSA-199977", "R-HSA-597592", "R-HSA-9007101", "R-HSA-392499", "R-HSA-8876198", "R-HSA-5653656", "R-HSA-204005", "R-HSA-199991", "R-HSA-948021", "R-HSA-446203" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q96Q05", "ensembl_id": "ENSG00000167632", "entrez_id": "83696", "chromosome_number": "8", "lastmodified": "2021-10-18T11:00:44.469386" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "909" }, { "type": "SmallVariant", "id": "1856" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TRAPPC9/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TRAPPC9/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "284" }, { "type": "GeneCombination", "id": "616" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TRAPPC9/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TRAPPC9/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/TRAPPC9/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }