Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/512/genes/?format=api
{ "data": [ { "type": "Gene", "id": "INVS", "attributes": { "go_molecular_function": [ "protein binding", "calmodulin binding" ], "pathway_id": [ "kegg_path:hsa04310", "kegg_path:hsa04310" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9Y283", "ensembl_id": "ENSG00000119509", "entrez_id": "27130", "chromosome_number": "9", "lastmodified": "2021-10-18T11:00:44.619381" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "416" }, { "type": "SmallVariant", "id": "1499" }, { "type": "SmallVariant", "id": "1593" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/INVS/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/INVS/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "140" }, { "type": "GeneCombination", "id": "480" }, { "type": "GeneCombination", "id": "512" }, { "type": "GeneCombination", "id": "525" }, { "type": "GeneCombination", "id": "550" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/INVS/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/INVS/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/INVS/?format=api" } }, { "type": "Gene", "id": "NID1", "attributes": { "go_molecular_function": [ "laminin binding", "extracellular matrix binding", "laminin-1 binding", "extracellular matrix structural constituent", "collagen binding" ], "pathway_id": [ "R-HSA-1474228", "R-HSA-1474244", "R-HSA-3000157" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P14543", "ensembl_id": "ENSG00000116962", "entrez_id": "4811", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.306679" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1589" }, { "type": "SmallVariant", "id": "1637" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NID1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NID1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "512" }, { "type": "GeneCombination", "id": "530" }, { "type": "GeneCombination", "id": "540" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NID1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NID1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NID1/?format=api" } }, { "type": "Gene", "id": "NOS2", "attributes": { "go_molecular_function": [ "protein binding", "FMN binding", "nitric-oxide synthase activity", "heme binding", "tetrahydrobiopterin binding", "arginine binding", "flavin adenine dinucleotide binding", "NADP binding", "metal ion binding", "calmodulin binding", "oxidoreductase activity" ], "pathway_id": [ "R-HSA-9635486", "kegg_path:hsa05010", "kegg_path:hsa05145", "R-HSA-9636249", "R-HSA-9637687", "kegg_path:hsa01100", "kegg_path:hsa05146", "R-HSA-1222556", "R-HSA-109582", "R-HSA-1643685", "R-HSA-9637690", "kegg_path:hsa00330", "kegg_path:hsa05152", "R-HSA-168249", "R-HSA-9033241", "R-HSA-168256", "R-HSA-9609507", "kegg_path:hsa05222", "kegg_path:hsa00220", "kegg_path:hsa04066", "R-HSA-418346", "kegg_path:hsa04371", "R-HSA-392154", "kegg_path:hsa05142", "R-HSA-5663205", "kegg_path:hsa05133", "kegg_path:hsa05140", "kegg_path:hsa05200", "R-HSA-449147", "kegg_path:hsa05022", "kegg_path:hsa04020", "R-HSA-6785807", "kegg_path:hsa04146", "kegg_path:hsa04926", "kegg_path:hsa05014", "R-HSA-1280215" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P35228", "ensembl_id": "ENSG00000007171", "entrez_id": "4843", "chromosome_number": "17", "lastmodified": "2021-10-18T11:00:44.533688" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1591" }, { "type": "SmallVariant", "id": "1639" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NOS2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NOS2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "512" }, { "type": "GeneCombination", "id": "531" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NOS2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NOS2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NOS2/?format=api" } }, { "type": "Gene", "id": "SALL2", "attributes": { "go_molecular_function": [ "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "protein binding", "DNA-binding transcription activator activity, RNA polymerase II-specific", "DNA binding", "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "DNA-binding transcription factor activity, RNA polymerase II-specific", "metal ion binding" ], "pathway_id": [], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q9Y467", "ensembl_id": "ENSG00000165821", "entrez_id": "6297", "chromosome_number": "14", "lastmodified": "2021-10-18T11:00:44.473370" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1532" }, { "type": "SmallVariant", "id": "1590" }, { "type": "SmallVariant", "id": "1653" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SALL2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SALL2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "492" }, { "type": "GeneCombination", "id": "512" }, { "type": "GeneCombination", "id": "521" }, { "type": "GeneCombination", "id": "537" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SALL2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SALL2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SALL2/?format=api" } }, { "type": "Gene", "id": "SCRIB", "attributes": { "go_molecular_function": [], "pathway_id": [ "kegg_path:hsa05203", "R-HSA-4086400", "kegg_path:hsa04390", "kegg_path:hsa05165", "R-HSA-3858494", "kegg_path:hsa04530", "R-HSA-4608870", "kegg_path:hsa05165", "kegg_path:hsa04390", "kegg_path:hsa04390", "kegg_path:hsa05165", "kegg_path:hsa05203", "kegg_path:hsa04530", "R-HSA-195721", "R-HSA-162582", "kegg_path:hsa04530", "R-HSA-195721", "R-HSA-162582", "kegg_path:hsa05165", "kegg_path:hsa04390", "kegg_path:hsa05203", "R-HSA-4086400", "kegg_path:hsa04530", "R-HSA-4608870", "R-HSA-3858494", "kegg_path:hsa05203" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q14160", "ensembl_id": "ENSG00000180900", "entrez_id": "23513", "chromosome_number": "8", "lastmodified": "2021-10-18T11:00:44.361258" }, "relationships": { "variant_set": { "meta": { "count": 9 }, "data": [ { "type": "SmallVariant", "id": "1074" }, { "type": "SmallVariant", "id": "1076" }, { "type": "SmallVariant", "id": "1078" }, { "type": "SmallVariant", "id": "1082" }, { "type": "SmallVariant", "id": "1535" }, { "type": "SmallVariant", "id": "1588" }, { "type": "SmallVariant", "id": "1592" }, { "type": "SmallVariant", "id": "1616" }, { "type": "SmallVariant", "id": "1682" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SCRIB/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SCRIB/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 7 }, "data": [ { "type": "GeneCombination", "id": "351" }, { "type": "GeneCombination", "id": "353" }, { "type": "GeneCombination", "id": "492" }, { "type": "GeneCombination", "id": "511" }, { "type": "GeneCombination", "id": "512" }, { "type": "GeneCombination", "id": "519" }, { "type": "GeneCombination", "id": "547" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SCRIB/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SCRIB/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SCRIB/?format=api" } }, { "type": "Gene", "id": "SHROOM2", "attributes": { "go_molecular_function": [ "protein binding", "actin filament binding", "beta-catenin binding", "ligand-gated sodium channel activity", "actin binding" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "Q13796", "ensembl_id": "ENSG00000146950", "entrez_id": "357", "chromosome_number": "X", "lastmodified": "2021-10-18T11:00:44.447214" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "1594" }, { "type": "SmallVariant", "id": "1636" }, { "type": "SmallVariant", "id": "1667" }, { "type": "SmallVariant", "id": "2232" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SHROOM2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SHROOM2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "512" }, { "type": "GeneCombination", "id": "529" }, { "type": "GeneCombination", "id": "542" }, { "type": "GeneCombination", "id": "757" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SHROOM2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SHROOM2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SHROOM2/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 6 } }