Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/504/genes/?format=api
{ "data": [ { "type": "Gene", "id": "INSR", "attributes": { "go_molecular_function": [ "['protein tyrosine kinase activity', 'insulin-like growth factor II binding', 'phosphatidylinositol 3-kinase binding', 'insulin binding', 'insulin-like growth factor receptor binding', 'PTB domain binding', 'protein serine/threonine/tyrosine kinase activity', 'transmembrane receptor protein tyrosine kinase activity', 'protein binding', 'protein domain specific binding', 'insulin receptor substrate binding', 'insulin-like growth factor I binding', 'protein-containing complex binding', 'GTP binding', 'amyloid-beta binding', 'insulin-activated receptor activity', 'cargo receptor activity', 'ATP binding']" ], "pathway_id": [ "kegg_path:hsa04010", "kegg_path:hsa04014", "kegg_path:hsa04015", "kegg_path:hsa04022", "kegg_path:hsa04066", "kegg_path:hsa04068", "kegg_path:hsa04072", "kegg_path:hsa04150", "kegg_path:hsa04151", "kegg_path:hsa04152", "kegg_path:hsa04211", "kegg_path:hsa04213", "kegg_path:hsa04520", "kegg_path:hsa04910", "kegg_path:hsa04913", "kegg_path:hsa04923", "kegg_path:hsa04930", "kegg_path:hsa04931", "kegg_path:hsa04932", "kegg_path:hsa04960", "kegg_path:hsa05010", "R-HSA-1257604", "R-HSA-162582", "R-HSA-199418", "R-HSA-6811558", "R-HSA-74713", "R-HSA-74749", "R-HSA-74751", "R-HSA-74752", "R-HSA-77387", "R-HSA-9006925", "R-HSA-9006934" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P06213", "ensembl_id": "None", "entrez_id": "ENSG00000171105", "chromosome_number": "19", "lastmodified": "2021-10-18T11:00:44.378754" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1568" }, { "type": "SmallVariant", "id": "3702" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/INSR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/INSR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "504" }, { "type": "GeneCombination", "id": "1252" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/INSR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/INSR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/INSR/?format=api" } }, { "type": "Gene", "id": "NOS3", "attributes": { "go_molecular_function": [ "protein binding", "FMN binding", "nitric-oxide synthase activity", "heme binding", "flavin adenine dinucleotide binding", "NADP binding", "calmodulin binding", "oxidoreductase activity" ], "pathway_id": [ "R-HSA-9006931", "kegg_path:hsa04371", "R-HSA-392154", "R-HSA-418346", "R-HSA-9009391", "kegg_path:hsa04921", "R-HSA-8978934", "kegg_path:hsa04915", "kegg_path:hsa04926", "R-HSA-4420097", "kegg_path:hsa05418", "kegg_path:hsa04020", "R-HSA-203754", "R-HSA-162582", "R-HSA-203641", "R-HSA-196854", "kegg_path:hsa04071", "R-HSA-203615", "R-HSA-5218920", "R-HSA-109582", "R-HSA-1222556", "kegg_path:hsa01100", "R-HSA-1430728", "kegg_path:hsa04933", "kegg_path:hsa04611", "R-HSA-9006934", "R-HSA-1474151", "R-HSA-168256", "kegg_path:hsa04931", "R-HSA-168249", "kegg_path:hsa00330", "R-HSA-8939211", "kegg_path:hsa04151", "kegg_path:hsa04022", "R-HSA-194138", "kegg_path:hsa00220", "kegg_path:hsa04066", "R-HSA-202131", "kegg_path:hsa04370" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P29474", "ensembl_id": "ENSG00000164867", "entrez_id": "4846", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:44.429024" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1569" }, { "type": "SmallVariant", "id": "1587" }, { "type": "SmallVariant", "id": "1663" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NOS3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NOS3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "504" }, { "type": "GeneCombination", "id": "511" }, { "type": "GeneCombination", "id": "541" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NOS3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NOS3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NOS3/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 2 } }