Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/346/genes/?format=api
{ "data": [ { "type": "Gene", "id": "DES", "attributes": { "go_molecular_function": [ "structural constituent of cytoskeleton", "protein binding", "identical protein binding" ], "pathway_id": [ "R-HSA-390522", "kegg_path:hsa05414", "kegg_path:hsa05412", "kegg_path:hsa05410", "R-HSA-397014" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P17661", "ensembl_id": "ENSG00000175084", "entrez_id": "1674", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.574288" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "370" }, { "type": "SmallVariant", "id": "891" }, { "type": "SmallVariant", "id": "1060" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/DES/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/DES/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "128" }, { "type": "GeneCombination", "id": "276" }, { "type": "GeneCombination", "id": "346" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/DES/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/DES/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/DES/?format=api" } }, { "type": "Gene", "id": "FBN1", "attributes": { "go_molecular_function": [ "protein binding", "identical protein binding" ], "pathway_id": [ "R-HSA-1474244", "R-HSA-216083", "R-HSA-1474228", "R-HSA-8957275", "kegg_path:hsa04350", "R-HSA-1566948", "R-HSA-2129379", "R-HSA-381426", "R-HSA-597592", "R-HSA-392499" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P35555", "ensembl_id": "ENSG00000166147", "entrez_id": "2200", "chromosome_number": "15", "lastmodified": "2021-10-18T11:00:44.504470" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "575" }, { "type": "SmallVariant", "id": "1058" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FBN1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FBN1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "198" }, { "type": "GeneCombination", "id": "346" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FBN1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FBN1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FBN1/?format=api" } }, { "type": "Gene", "id": "FREM1", "attributes": { "go_molecular_function": [ "None" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "None", "ensembl_id": "None", "entrez_id": "None", "chromosome_number": "9", "lastmodified": "2021-10-18T11:00:45.012677" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1059" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FREM1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FREM1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "346" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FREM1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FREM1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FREM1/?format=api" } }, { "type": "Gene", "id": "MET", "attributes": { "go_molecular_function": [ "protein tyrosine kinase activity", "protein binding" ], "pathway_id": [ "kegg_path:hsa05226", "R-HSA-8851805", "R-HSA-2219530", "kegg_path:hsa05202", "kegg_path:hsa01521", "kegg_path:hsa05206", "kegg_path:hsa05211", "kegg_path:hsa05100", "R-HSA-9006934", "kegg_path:hsa04015", "R-HSA-199418", "R-HSA-5663202", "kegg_path:hsa05200", "kegg_path:hsa04010", "kegg_path:hsa05223", "R-HSA-5684996", "R-HSA-8874081", "R-HSA-8875555", "R-HSA-162582", "kegg_path:hsa04020", "R-HSA-8865999", "kegg_path:hsa04014", "R-HSA-1266738", "kegg_path:hsa05205", "R-HSA-5663205", "R-HSA-8876384", "R-HSA-6807004", "kegg_path:hsa05202", "R-HSA-2219528", "R-HSA-400685", "R-HSA-8851907", "kegg_path:hsa01521", "kegg_path:hsa05206", "kegg_path:hsa05230", "kegg_path:hsa05211", "kegg_path:hsa05225", "kegg_path:hsa04151", "kegg_path:hsa04360", "kegg_path:hsa05226", "kegg_path:hsa05120", "kegg_path:hsa04510", "R-HSA-73857", "R-HSA-8986944", "R-HSA-9022699", "kegg_path:hsa04015", "R-HSA-8875513", "kegg_path:hsa04520", "kegg_path:hsa05100", "kegg_path:hsa05218", "kegg_path:hsa04010", "kegg_path:hsa05223", "R-HSA-5673001", "R-HSA-416550", "kegg_path:hsa04020", "R-HSA-8875878", "R-HSA-6806942", "kegg_path:hsa05144", "R-HSA-8875656", "R-HSA-9006925", "kegg_path:hsa05200", "R-HSA-1257604", "R-HSA-8875360", "kegg_path:hsa05205", "R-HSA-8875791", "R-HSA-212436", "R-HSA-6811558", "R-HSA-422475", "kegg_path:hsa04014", "R-HSA-5683057", "R-HSA-9675108", "kegg_path:hsa04151", "kegg_path:hsa04360", "R-HSA-1643685", "kegg_path:hsa04510", "kegg_path:hsa05120", "kegg_path:hsa05230", "kegg_path:hsa05225", "kegg_path:hsa04520", "kegg_path:hsa05218", "R-HSA-6806834", "R-HSA-373755", "R-HSA-74160", "kegg_path:hsa05144" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P08581", "ensembl_id": "ENSG00000105976", "entrez_id": "4233", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:44.557330" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1062" }, { "type": "SmallVariant", "id": "1873" }, { "type": "SmallVariant", "id": "1958" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MET/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MET/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "346" }, { "type": "GeneCombination", "id": "622" }, { "type": "GeneCombination", "id": "669" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MET/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MET/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MET/?format=api" } }, { "type": "Gene", "id": "PAX3", "attributes": { "go_molecular_function": [ "protein binding", "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "sequence-specific double-stranded DNA binding", "DNA-binding transcription factor activity, RNA polymerase II-specific", "sequence-specific DNA binding", "DNA-binding transcription factor activity", "DNA binding" ], "pathway_id": [ "R-HSA-4839726", "kegg_path:hsa05202", "R-HSA-3214847", "R-HSA-3247509" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P23760", "ensembl_id": "ENSG00000135903", "entrez_id": "5077", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.713807" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "284" }, { "type": "SmallVariant", "id": "1061" }, { "type": "SmallVariant", "id": "1580" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PAX3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PAX3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "102" }, { "type": "GeneCombination", "id": "346" }, { "type": "GeneCombination", "id": "508" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PAX3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PAX3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PAX3/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 5 } }