Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1114/genes/?format=api
{ "data": [ { "type": "Gene", "id": "AR", "attributes": { "go_molecular_function": [ "['zinc ion binding', 'transcription cis-regulatory region binding', 'nuclear receptor activity', 'steroid binding', 'DNA-binding transcription factor activity, RNA polymerase II-specific', 'RNA polymerase II-specific DNA-binding transcription factor binding', 'protein binding', 'DNA-binding transcription factor activity', 'POU domain binding', 'androgen binding', 'transcription coactivator binding', 'chromatin binding', 'ATPase binding', 'beta-catenin binding', 'RNA polymerase II general transcription initiation factor binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'enzyme binding', 'DNA-binding transcription activator activity, RNA polymerase II-specific', 'signaling receptor binding']" ], "pathway_id": [ "kegg_path:hsa04114", "kegg_path:hsa05200", "kegg_path:hsa05215", "R-HSA-162582", "R-HSA-194315", "R-HSA-195258", "R-HSA-212436", "R-HSA-2262752", "R-HSA-2990846", "R-HSA-3108232", "R-HSA-3371497", "R-HSA-383280", "R-HSA-392499", "R-HSA-4090294", "R-HSA-5625740", "R-HSA-5625886", "R-HSA-5688426", "R-HSA-5689880", "R-HSA-597592", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878166", "R-HSA-8940973", "R-HSA-8941326", "R-HSA-8953897" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P10275", "ensembl_id": "None", "entrez_id": "ENSG00000169083", "chromosome_number": "X", "lastmodified": "2021-10-18T11:00:44.665425" }, "relationships": { "variant_set": { "meta": { "count": 15 }, "data": [ { "type": "SmallVariant", "id": "580" }, { "type": "CopyNumberVariant", "id": "2184" }, { "type": "SmallVariant", "id": "646" }, { "type": "SmallVariant", "id": "2159" }, { "type": "SmallVariant", "id": "2164" }, { "type": "SmallVariant", "id": "2168" }, { "type": "SmallVariant", "id": "2171" }, { "type": "SmallVariant", "id": "2173" }, { "type": "SmallVariant", "id": "2175" }, { "type": "SmallVariant", "id": "2177" }, { "type": "SmallVariant", "id": "2180" }, { "type": "SmallVariant", "id": "2182" }, { "type": "SmallVariant", "id": "3248" }, { "type": "SmallVariant", "id": "3292" }, { "type": "SmallVariant", "id": "3311" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 15 }, "data": [ { "type": "GeneCombination", "id": "200" }, { "type": "GeneCombination", "id": "217" }, { "type": "GeneCombination", "id": "736" }, { "type": "GeneCombination", "id": "737" }, { "type": "GeneCombination", "id": "738" }, { "type": "GeneCombination", "id": "739" }, { "type": "GeneCombination", "id": "740" }, { "type": "GeneCombination", "id": "741" }, { "type": "GeneCombination", "id": "742" }, { "type": "GeneCombination", "id": "743" }, { "type": "GeneCombination", "id": "744" }, { "type": "GeneCombination", "id": "745" }, { "type": "GeneCombination", "id": "1089" }, { "type": "GeneCombination", "id": "1108" }, { "type": "GeneCombination", "id": "1114" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/AR/?format=api" } }, { "type": "Gene", "id": "FLNA", "attributes": { "go_molecular_function": [ "['RNA binding', 'Fc-gamma receptor I complex binding', 'small GTPase binding', 'actin filament binding', 'protein kinase C binding', 'transmembrane transporter binding', 'cadherin binding', 'potassium channel regulator activity', 'kinase binding', 'G protein-coupled receptor binding', 'protein binding', 'GTPase binding', 'protein homodimerization activity', 'DNA-binding transcription factor binding']" ], "pathway_id": [ "kegg_path:hsa04010", "kegg_path:hsa04510", "kegg_path:hsa05132", "kegg_path:hsa05205", "R-HSA-109582", "R-HSA-114608", "R-HSA-1169410", "R-HSA-1280215", "R-HSA-1500931", "R-HSA-162582", "R-HSA-168256", "R-HSA-194315", "R-HSA-195258", "R-HSA-430116", "R-HSA-446353", "R-HSA-446728", "R-HSA-5627123", "R-HSA-76002", "R-HSA-76005", "R-HSA-8983711", "R-HSA-913531", "kegg_path:hsa04010", "kegg_path:hsa04510", "kegg_path:hsa05132", "kegg_path:hsa05205", "kegg_path:hsa04010", "kegg_path:hsa04510", "kegg_path:hsa05132", "kegg_path:hsa05205", "kegg_path:hsa04010", "kegg_path:hsa04510", "kegg_path:hsa05132", "kegg_path:hsa05205", "R-HSA-109582", "R-HSA-114608", "R-HSA-1169410", "R-HSA-1280215", "R-HSA-1500931", "R-HSA-162582", "R-HSA-168256", "R-HSA-194315", "R-HSA-195258", "R-HSA-430116", "R-HSA-446353", "R-HSA-446728", "R-HSA-5627123", "R-HSA-76002", "R-HSA-76005", "R-HSA-8983711", "R-HSA-913531", "kegg_path:hsa04010", "kegg_path:hsa04510", "kegg_path:hsa05132", "kegg_path:hsa05205", "kegg_path:hsa04010", "kegg_path:hsa04510", "kegg_path:hsa05132", "kegg_path:hsa05205" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P21333", "ensembl_id": "None", "entrez_id": "ENSG00000196924", "chromosome_number": "X", "lastmodified": "2021-10-18T11:00:44.390873" }, "relationships": { "variant_set": { "meta": { "count": 6 }, "data": [ { "type": "SmallVariant", "id": "767" }, { "type": "SmallVariant", "id": "1298" }, { "type": "SmallVariant", "id": "3177" }, { "type": "SmallVariant", "id": "3241" }, { "type": "SmallVariant", "id": "3277" }, { "type": "SmallVariant", "id": "3314" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FLNA/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FLNA/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "240" }, { "type": "GeneCombination", "id": "410" }, { "type": "GeneCombination", "id": "1061" }, { "type": "GeneCombination", "id": "1086" }, { "type": "GeneCombination", "id": "1102" }, { "type": "GeneCombination", "id": "1114" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FLNA/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FLNA/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FLNA/?format=api" } }, { "type": "Gene", "id": "GPRC6A", "attributes": { "go_molecular_function": [ "['G protein-coupled receptor activity']" ], "pathway_id": [ "kegg_path:hsa04621", "R-HSA-162582", "R-HSA-372790", "R-HSA-388396", "R-HSA-416476", "R-HSA-420499", "R-HSA-500792" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q5T6X5", "ensembl_id": "None", "entrez_id": "ENSG00000173612", "chromosome_number": "6", "lastmodified": "2023-05-16T12:02:33.486621" }, "relationships": { "variant_set": { "meta": { "count": 7 }, "data": [ { "type": "SmallVariant", "id": "3157" }, { "type": "SmallVariant", "id": "3183" }, { "type": "SmallVariant", "id": "3186" }, { "type": "SmallVariant", "id": "3202" }, { "type": "SmallVariant", "id": "3204" }, { "type": "SmallVariant", "id": "3239" }, { "type": "SmallVariant", "id": "3312" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GPRC6A/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GPRC6A/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 11 }, "data": [ { "type": "GeneCombination", "id": "1053" }, { "type": "GeneCombination", "id": "1063" }, { "type": "GeneCombination", "id": "1064" }, { "type": "GeneCombination", "id": "1069" }, { "type": "GeneCombination", "id": "1070" }, { "type": "GeneCombination", "id": "1085" }, { "type": "GeneCombination", "id": "1102" }, { "type": "GeneCombination", "id": "1105" }, { "type": "GeneCombination", "id": "1107" }, { "type": "GeneCombination", "id": "1111" }, { "type": "GeneCombination", "id": "1114" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GPRC6A/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GPRC6A/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GPRC6A/?format=api" } }, { "type": "Gene", "id": "ROR2", "attributes": { "go_molecular_function": [ "['Wnt-protein binding', 'mitogen-activated protein kinase kinase kinase binding', 'ATP binding', 'frizzled binding', 'protein binding', 'metal ion binding', 'coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway', 'protein serine/threonine/tyrosine kinase activity', 'transmembrane receptor protein tyrosine kinase activity']" ], "pathway_id": [ "kegg_path:hsa04310", "R-HSA-162582", "R-HSA-195721", "R-HSA-3858494", "R-HSA-4086400", "R-HSA-5140745" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q01974", "ensembl_id": "None", "entrez_id": "ENSG00000169071", "chromosome_number": "9", "lastmodified": "2021-10-18T11:00:44.743625" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "1531" }, { "type": "SmallVariant", "id": "1664" }, { "type": "SmallVariant", "id": "1669" }, { "type": "SmallVariant", "id": "3288" }, { "type": "SmallVariant", "id": "3313" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ROR2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ROR2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "491" }, { "type": "GeneCombination", "id": "541" }, { "type": "GeneCombination", "id": "543" }, { "type": "GeneCombination", "id": "1107" }, { "type": "GeneCombination", "id": "1114" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ROR2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ROR2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ROR2/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }