Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1036/genes/?format=api
{ "data": [ { "type": "Gene", "id": "CACNA1H", "attributes": { "go_molecular_function": [ "['low voltage-gated calcium channel activity', 'voltage-gated ion channel activity', 'voltage-gated sodium channel activity', 'protein binding', 'metal ion binding', 'scaffold protein binding']" ], "pathway_id": [ "kegg_path:hsa04010", "kegg_path:hsa04020", "kegg_path:hsa04713", "kegg_path:hsa04925", "kegg_path:hsa04927", "kegg_path:hsa04929", "kegg_path:hsa04934", "R-HSA-1266738", "R-HSA-375165", "R-HSA-419037", "R-HSA-422475", "R-HSA-9675108" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "O95180", "ensembl_id": "None", "entrez_id": "ENSG00000196557", "chromosome_number": "16", "lastmodified": "2021-10-18T11:00:44.379820" }, "relationships": { "variant_set": { "meta": { "count": 8 }, "data": [ { "type": "SmallVariant", "id": "653" }, { "type": "SmallVariant", "id": "674" }, { "type": "SmallVariant", "id": "690" }, { "type": "SmallVariant", "id": "1163" }, { "type": "SmallVariant", "id": "2061" }, { "type": "SmallVariant", "id": "2070" }, { "type": "SmallVariant", "id": "3065" }, { "type": "SmallVariant", "id": "3091" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CACNA1H/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CACNA1H/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 8 }, "data": [ { "type": "GeneCombination", "id": "218" }, { "type": "GeneCombination", "id": "220" }, { "type": "GeneCombination", "id": "222" }, { "type": "GeneCombination", "id": "373" }, { "type": "GeneCombination", "id": "711" }, { "type": "GeneCombination", "id": "715" }, { "type": "GeneCombination", "id": "1036" }, { "type": "GeneCombination", "id": "1028" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CACNA1H/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CACNA1H/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CACNA1H/?format=api" } }, { "type": "Gene", "id": "CACNA2D4", "attributes": { "go_molecular_function": [ "['voltage-gated calcium channel activity', 'metal ion binding']" ], "pathway_id": [ "kegg_path:hsa04010", "kegg_path:hsa04260", "kegg_path:hsa04261", "kegg_path:hsa04921", "kegg_path:hsa05410", "kegg_path:hsa05412", "kegg_path:hsa05414" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q7Z3S7", "ensembl_id": "None", "entrez_id": "ENSG00000151062", "chromosome_number": "12", "lastmodified": "2023-05-16T12:02:33.298460" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "3068" }, { "type": "SmallVariant", "id": "3090" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CACNA2D4/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CACNA2D4/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "1029" }, { "type": "GeneCombination", "id": "1036" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CACNA2D4/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CACNA2D4/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CACNA2D4/?format=api" } }, { "type": "Gene", "id": "RELN", "attributes": { "go_molecular_function": [ "['lipoprotein particle receptor binding', 'serine-type peptidase activity', 'very-low-density lipoprotein particle receptor binding', 'metal ion binding']" ], "pathway_id": [ "kegg_path:hsa04151", "kegg_path:hsa04510", "kegg_path:hsa04512", "kegg_path:hsa05017", "kegg_path:hsa05165", "R-HSA-1266738", "R-HSA-422475", "R-HSA-8866376", "R-HSA-9675108" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P78509", "ensembl_id": "None", "entrez_id": "ENSG00000189056", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:44.519444" }, "relationships": { "variant_set": { "meta": { "count": 24 }, "data": [ { "type": "SmallVariant", "id": "1852" }, { "type": "SmallVariant", "id": "1871" }, { "type": "SmallVariant", "id": "1891" }, { "type": "SmallVariant", "id": "1906" }, { "type": "SmallVariant", "id": "1930" }, { "type": "SmallVariant", "id": "1934" }, { "type": "SmallVariant", "id": "1936" }, { "type": "SmallVariant", "id": "1970" }, { "type": "SmallVariant", "id": "2332" }, { "type": "SmallVariant", "id": "2343" }, { "type": "SmallVariant", "id": "3063" }, { "type": "SmallVariant", "id": "3064" }, { "type": "SmallVariant", "id": "3069" }, { "type": "SmallVariant", "id": "3070" }, { "type": "SmallVariant", "id": "3072" }, { "type": "SmallVariant", "id": "3073" }, { "type": "SmallVariant", "id": "3075" }, { "type": "SmallVariant", "id": "3076" }, { "type": "SmallVariant", "id": "3079" }, { "type": "SmallVariant", "id": "3085" }, { "type": "SmallVariant", "id": "3088" }, { "type": "SmallVariant", "id": "3089" }, { "type": "SmallVariant", "id": "3092" }, { "type": "SmallVariant", "id": "3093" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RELN/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RELN/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 25 }, "data": [ { "type": "GeneCombination", "id": "644" }, { "type": "GeneCombination", "id": "615" }, { "type": "GeneCombination", "id": "621" }, { "type": "GeneCombination", "id": "630" }, { "type": "GeneCombination", "id": "639" }, { "type": "GeneCombination", "id": "642" }, { "type": "GeneCombination", "id": "643" }, { "type": "GeneCombination", "id": "652" }, { "type": "GeneCombination", "id": "653" }, { "type": "GeneCombination", "id": "654" }, { "type": "GeneCombination", "id": "663" }, { "type": "GeneCombination", "id": "664" }, { "type": "GeneCombination", "id": "668" }, { "type": "GeneCombination", "id": "670" }, { "type": "GeneCombination", "id": "676" }, { "type": "GeneCombination", "id": "785" }, { "type": "GeneCombination", "id": "791" }, { "type": "GeneCombination", "id": "1030" }, { "type": "GeneCombination", "id": "1031" }, { "type": "GeneCombination", "id": "1032" }, { "type": "GeneCombination", "id": "1033" }, { "type": "GeneCombination", "id": "1035" }, { "type": "GeneCombination", "id": "1036" }, { "type": "GeneCombination", "id": "1037" }, { "type": "GeneCombination", "id": "1028" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RELN/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RELN/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/RELN/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2024 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }