Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/432/genes/?format=api
{ "data": [ { "type": "Gene", "id": "C9orf72", "attributes": { "go_molecular_function": [ "guanyl-nucleotide exchange factor activity", "small GTPase binding", "protein binding" ], "pathway_id": [ "kegg_path:hsa04140", "kegg_path:hsa05014", "kegg_path:hsa05022" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q96LT7", "ensembl_id": "None", "entrez_id": "ENSG00000147894", "chromosome_number": "9", "lastmodified": "2021-10-18T11:00:44.423366" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "CopyNumberVariant", "id": "530" }, { "type": "CopyNumberVariant", "id": "1225" }, { "type": "CopyNumberVariant", "id": "1694" }, { "type": "CopyNumberVariant", "id": "1808" }, { "type": "CopyNumberVariant", "id": "3061" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/C9orf72/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/C9orf72/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 25 }, "data": [ { "type": "GeneCombination", "id": "175" }, { "type": "GeneCombination", "id": "176" }, { "type": "GeneCombination", "id": "177" }, { "type": "GeneCombination", "id": "377" }, { "type": "GeneCombination", "id": "390" }, { "type": "GeneCombination", "id": "413" }, { "type": "GeneCombination", "id": "428" }, { "type": "GeneCombination", "id": "429" }, { "type": "GeneCombination", "id": "430" }, { "type": "GeneCombination", "id": "431" }, { "type": "GeneCombination", "id": "432" }, { "type": "GeneCombination", "id": "433" }, { "type": "GeneCombination", "id": "435" }, { "type": "GeneCombination", "id": "449" }, { "type": "GeneCombination", "id": "450" }, { "type": "GeneCombination", "id": "552" }, { "type": "GeneCombination", "id": "556" }, { "type": "GeneCombination", "id": "557" }, { "type": "GeneCombination", "id": "558" }, { "type": "GeneCombination", "id": "600" }, { "type": "GeneCombination", "id": "603" }, { "type": "GeneCombination", "id": "553" }, { "type": "GeneCombination", "id": "1147" }, { "type": "GeneCombination", "id": "1148" }, { "type": "GeneCombination", "id": "1149" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/C9orf72/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/C9orf72/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/C9orf72/?format=api" } }, { "type": "Gene", "id": "FUS", "attributes": { "go_molecular_function": [ "['DNA binding', 'chromatin binding', \"mRNA 3'-UTR binding\", 'transcription coregulator activity', 'protein binding', 'RNA binding', 'transcription coactivator activity', 'metal ion binding', 'identical protein binding']" ], "pathway_id": [ "kegg_path:hsa03013", "kegg_path:hsa03015", "kegg_path:hsa03040", "kegg_path:hsa05014", "kegg_path:hsa05022", "kegg_path:hsa05202", "R-HSA-72163", "R-HSA-72172", "R-HSA-72203", "R-HSA-8953854", "kegg_path:hsa03013", "kegg_path:hsa03015", "kegg_path:hsa03040", "kegg_path:hsa05014", "kegg_path:hsa05022", "kegg_path:hsa05202" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P35637", "ensembl_id": "None", "entrez_id": "ENSG00000089280", "chromosome_number": "16", "lastmodified": "2021-10-18T11:00:44.299468" }, "relationships": { "variant_set": { "meta": { "count": 13 }, "data": [ { "type": "SmallVariant", "id": "536" }, { "type": "SmallVariant", "id": "539" }, { "type": "SmallVariant", "id": "1373" }, { "type": "SmallVariant", "id": "1374" }, { "type": "SmallVariant", "id": "1389" }, { "type": "SmallVariant", "id": "1391" }, { "type": "SmallVariant", "id": "1432" }, { "type": "SmallVariant", "id": "1708" }, { "type": "SmallVariant", "id": "1711" }, { "type": "SmallVariant", "id": "1806" }, { "type": "SmallVariant", "id": "2101" }, { "type": "SmallVariant", "id": "3436" }, { "type": "SmallVariant", "id": "3606" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FUS/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FUS/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 11 }, "data": [ { "type": "GeneCombination", "id": "180" }, { "type": "GeneCombination", "id": "182" }, { "type": "GeneCombination", "id": "431" }, { "type": "GeneCombination", "id": "432" }, { "type": "GeneCombination", "id": "438" }, { "type": "GeneCombination", "id": "453" }, { "type": "GeneCombination", "id": "559" }, { "type": "GeneCombination", "id": "560" }, { "type": "GeneCombination", "id": "727" }, { "type": "GeneCombination", "id": "913" }, { "type": "GeneCombination", "id": "914" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FUS/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FUS/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FUS/?format=api" } }, { "type": "Gene", "id": "OPTN", "attributes": { "go_molecular_function": [ "['small GTPase binding', 'protein-macromolecule adaptor activity', 'protein C-terminus binding', 'protein binding', 'polyubiquitin modification-dependent protein binding', 'K63-linked polyubiquitin modification-dependent protein binding', 'metal ion binding', 'identical protein binding']" ], "pathway_id": [ "kegg_path:hsa04137", "kegg_path:hsa05014", "kegg_path:hsa05022", "R-HSA-1640170", "R-HSA-199991", "R-HSA-2565942", "R-HSA-453274", "R-HSA-5653656", "R-HSA-69275", "R-HSA-69278", "R-HSA-8854214", "R-HSA-9007101" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q96CV9", "ensembl_id": "None", "entrez_id": "ENSG00000123240", "chromosome_number": "10", "lastmodified": "2021-10-18T11:00:44.918424" }, "relationships": { "variant_set": { "meta": { "count": 14 }, "data": [ { "type": "SmallVariant", "id": "791" }, { "type": "SmallVariant", "id": "922" }, { "type": "SmallVariant", "id": "930" }, { "type": "SmallVariant", "id": "1171" }, { "type": "SmallVariant", "id": "1224" }, { "type": "SmallVariant", "id": "1375" }, { "type": "SmallVariant", "id": "1376" }, { "type": "SmallVariant", "id": "1387" }, { "type": "SmallVariant", "id": "1393" }, { "type": "SmallVariant", "id": "1436" }, { "type": "SmallVariant", "id": "1707" }, { "type": "SmallVariant", "id": "1710" }, { "type": "SmallVariant", "id": "2201" }, { "type": "SmallVariant", "id": "3601" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/OPTN/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/OPTN/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 13 }, "data": [ { "type": "GeneCombination", "id": "248" }, { "type": "GeneCombination", "id": "290" }, { "type": "GeneCombination", "id": "294" }, { "type": "GeneCombination", "id": "295" }, { "type": "GeneCombination", "id": "297" }, { "type": "GeneCombination", "id": "300" }, { "type": "GeneCombination", "id": "377" }, { "type": "GeneCombination", "id": "390" }, { "type": "GeneCombination", "id": "432" }, { "type": "GeneCombination", "id": "455" }, { "type": "GeneCombination", "id": "560" }, { "type": "GeneCombination", "id": "1212" }, { "type": "GeneCombination", "id": "750" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/OPTN/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/OPTN/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/OPTN/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2024 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }