Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1038/genes/?format=api
{ "data": [ { "type": "Gene", "id": "APOE", "attributes": { "go_molecular_function": [ "['lipid binding', 'protein binding', 'tau protein binding', 'structural molecule activity', 'identical protein binding', 'amyloid-beta binding', 'metal chelating activity', 'low-density lipoprotein particle receptor binding', 'lipoprotein particle binding', 'very-low-density lipoprotein particle receptor binding', 'heparin binding', 'protein homodimerization activity', 'phospholipid binding', 'cholesterol transfer activity', 'phosphatidylcholine-sterol O-acyltransferase activator activity', 'protein-containing complex binding', 'signaling receptor binding', 'protein dimerization activity', 'lipid transporter activity', 'heparan sulfate proteoglycan binding', 'antioxidant activity']" ], "pathway_id": [ "kegg_path:hsa04979", "kegg_path:hsa05010", "kegg_path:hsa04979", "kegg_path:hsa05010", "R-HSA-1236394", "R-HSA-1251985", "R-HSA-1430728", "R-HSA-162582", "R-HSA-174824", "R-HSA-196854", "R-HSA-212436", "R-HSA-2173782", "R-HSA-2187338", "R-HSA-3000480", "R-HSA-372790", "R-HSA-381426", "R-HSA-382551", "R-HSA-388396", "R-HSA-392499", "R-HSA-418594", "R-HSA-5653656", "R-HSA-597592", "R-HSA-6806667", "R-HSA-73857", "R-HSA-74160", "R-HSA-8864260", "R-HSA-8957275", "R-HSA-8963888", "R-HSA-8963898", "R-HSA-8963899", "R-HSA-8963901", "R-HSA-8964026", "R-HSA-8964043", "R-HSA-8964058", "R-HSA-9006931", "R-HSA-9006934", "R-HSA-9024446", "R-HSA-9029569", "R-HSA-975634" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P02649", "ensembl_id": "None", "entrez_id": "ENSG00000130203", "chromosome_number": "19", "lastmodified": "2023-05-16T12:02:33.350420" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3100" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/APOE/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/APOE/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "1038" }, { "type": "GeneCombination", "id": "1039" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/APOE/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/APOE/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/APOE/?format=api" } }, { "type": "Gene", "id": "CHAT", "attributes": { "go_molecular_function": [ "['choline O-acetyltransferase activity']" ], "pathway_id": [ "kegg_path:hsa00564", "kegg_path:hsa04725", "R-HSA-112310", "R-HSA-112315", "R-HSA-112316", "R-HSA-1430728", "R-HSA-1483191", "R-HSA-1483206", "R-HSA-1483257", "R-HSA-264642", "R-HSA-556833" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P28329", "ensembl_id": "None", "entrez_id": "ENSG00000070748", "chromosome_number": "10", "lastmodified": "2021-10-18T11:00:44.600497" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "695" }, { "type": "SmallVariant", "id": "3099" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CHAT/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CHAT/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "223" }, { "type": "GeneCombination", "id": "1038" }, { "type": "GeneCombination", "id": "1039" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CHAT/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CHAT/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CHAT/?format=api" } }, { "type": "Gene", "id": "MAPT", "attributes": { "go_molecular_function": [ "['enzyme binding', 'single-stranded DNA binding', 'histone-dependent DNA binding', 'double-stranded DNA binding', 'sequence-specific DNA binding', 'minor groove of adenine-thymine-rich DNA binding', 'SH3 domain binding', 'Hsp90 protein binding', 'protein kinase binding', 'lipoprotein particle binding', 'RNA binding', 'dynactin binding', 'protein phosphatase 2A binding', 'identical protein binding', 'microtubule binding', 'phosphatidylinositol binding', 'chaperone binding', 'phosphatidylinositol bisphosphate binding', 'DNA binding', 'protein-macromolecule adaptor activity', 'apolipoprotein binding', 'protein binding', 'microtubule lateral binding', 'actin binding']" ], "pathway_id": [ "kegg_path:hsa04010", "kegg_path:hsa05010", "kegg_path:hsa05012", "kegg_path:hsa05022", "kegg_path:hsa04010", "kegg_path:hsa05010", "kegg_path:hsa05012", "kegg_path:hsa05022", "R-HSA-109581", "R-HSA-111465", "R-HSA-264870", "R-HSA-5357801", "R-HSA-75153" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P10636", "ensembl_id": "None", "entrez_id": "ENSG00000186868", "chromosome_number": "17", "lastmodified": "2021-10-18T11:00:44.827622" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "1435" }, { "type": "SmallVariant", "id": "1441" }, { "type": "SmallVariant", "id": "3098" }, { "type": "SmallVariant", "id": "3423" }, { "type": "SmallVariant", "id": "3438" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAPT/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAPT/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "454" }, { "type": "GeneCombination", "id": "457" }, { "type": "GeneCombination", "id": "1038" }, { "type": "GeneCombination", "id": "1039" }, { "type": "GeneCombination", "id": "1149" }, { "type": "GeneCombination", "id": "1153" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAPT/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAPT/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MAPT/?format=api" } }, { "type": "Gene", "id": "PSEN1", "attributes": { "go_molecular_function": [ "['ATPase binding', 'beta-catenin binding', 'calcium channel activity', 'PDZ domain binding', 'growth factor receptor binding', 'cadherin binding', 'endopeptidase activity', 'aspartic endopeptidase activity, intramembrane cleaving', 'aspartic-type endopeptidase activity', 'protein binding']" ], "pathway_id": [ "kegg_path:hsa04310", "kegg_path:hsa04330", "kegg_path:hsa04722", "kegg_path:hsa05010", "kegg_path:hsa05022", "kegg_path:hsa05165", "kegg_path:hsa04310", "kegg_path:hsa04330", "kegg_path:hsa04722", "kegg_path:hsa05010", "kegg_path:hsa05022", "kegg_path:hsa05165", "R-HSA-1236394", "R-HSA-1251985", "R-HSA-1266738", "R-HSA-1474228", "R-HSA-1474244", "R-HSA-157118", "R-HSA-162582", "R-HSA-1643685", "R-HSA-168249", "R-HSA-168256", "R-HSA-193692", "R-HSA-193704", "R-HSA-1980143", "R-HSA-1980145", "R-HSA-204998", "R-HSA-205043", "R-HSA-2122948", "R-HSA-2644602", "R-HSA-2644603", "R-HSA-2644606", "R-HSA-2682334", "R-HSA-2894858", "R-HSA-2894862", "R-HSA-2979096", "R-HSA-3928665", "R-HSA-422475", "R-HSA-5663202", "R-HSA-6798695", "R-HSA-73887", "R-HSA-9006934", "R-HSA-9012852", "R-HSA-9013507", "R-HSA-9013694", "R-HSA-9013700", "R-HSA-9017802", "R-HSA-9675108" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P49768", "ensembl_id": "None", "entrez_id": "ENSG00000080815", "chromosome_number": "14", "lastmodified": "2023-05-16T12:02:33.338970" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3096" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PSEN1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PSEN1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "1038" }, { "type": "GeneCombination", "id": "1039" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PSEN1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PSEN1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PSEN1/?format=api" } }, { "type": "Gene", "id": "SORL1", "attributes": { "go_molecular_function": [ "['amyloid-beta binding', 'small GTPase binding', 'neuropeptide binding', 'transmembrane signaling receptor activity', 'protein binding', 'low-density lipoprotein particle binding', 'low-density lipoprotein particle receptor activity']" ], "pathway_id": [ "R-HSA-392499", "R-HSA-977225" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q92673", "ensembl_id": "None", "entrez_id": "ENSG00000137642", "chromosome_number": "11", "lastmodified": "2023-05-16T12:02:32.497689" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "2638" }, { "type": "SmallVariant", "id": "3097" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SORL1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SORL1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "879" }, { "type": "GeneCombination", "id": "1038" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SORL1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SORL1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SORL1/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 5 } }