Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1201/genes/?format=api
{ "data": [ { "type": "Gene", "id": "COL6A5", "attributes": { "go_molecular_function": [ "['extracellular matrix structural constituent conferring tensile strength', 'protein binding']" ], "pathway_id": [ "kegg_path:hsa04151", "kegg_path:hsa04510", "kegg_path:hsa04512", "kegg_path:hsa04974", "kegg_path:hsa05165", "R-HSA-1266738", "R-HSA-1442490", "R-HSA-1474228", "R-HSA-1474244", "R-HSA-1474290", "R-HSA-162582", "R-HSA-1650814", "R-HSA-186797", "R-HSA-2022090", "R-HSA-216083", "R-HSA-3000178", "R-HSA-375165", "R-HSA-419037", "R-HSA-422475", "R-HSA-8948216", "R-HSA-9006934", "R-HSA-9675108" ], "essential_gene": null, "status": "CU", "uniprot_acc": "E9PAL5", "ensembl_id": "None", "entrez_id": "ENSG00000172752", "chromosome_number": "3", "lastmodified": "2024-02-29T15:02:20.595451" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3565" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/COL6A5/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/COL6A5/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "1201" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/COL6A5/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/COL6A5/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/COL6A5/?format=api" } }, { "type": "Gene", "id": "GRHL1", "attributes": { "go_molecular_function": [ "['protein homodimerization activity', 'chromatin DNA binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'sequence-specific double-stranded DNA binding', 'sequence-specific DNA binding', 'protein binding', 'transcription cis-regulatory region binding', 'DNA-binding transcription activator activity, RNA polymerase II-specific', 'DNA-binding transcription factor activity, RNA polymerase II-specific']" ], "pathway_id": [ "R-HSA-1430728", "R-HSA-1989781", "R-HSA-400206", "R-HSA-556833" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q9NZI5", "ensembl_id": "None", "entrez_id": "ENSG00000134317", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.542708" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1574" }, { "type": "SmallVariant", "id": "3566" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GRHL1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GRHL1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "506" }, { "type": "GeneCombination", "id": "1201" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GRHL1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GRHL1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GRHL1/?format=api" } }, { "type": "Gene", "id": "SLC4A4", "attributes": { "go_molecular_function": [ "['protein binding', 'transmembrane transporter activity', 'symporter activity', 'inorganic anion exchanger activity', 'sodium:bicarbonate symporter activity', 'identical protein binding']" ], "pathway_id": [ "kegg_path:hsa04964", "kegg_path:hsa04972", "kegg_path:hsa04976", "R-HSA-1643685", "R-HSA-382551", "R-HSA-425381", "R-HSA-425393", "R-HSA-425407", "R-HSA-5619054", "R-HSA-5619102", "R-HSA-5619115" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9Y6R1", "ensembl_id": "None", "entrez_id": "ENSG00000080493", "chromosome_number": "4", "lastmodified": "2024-02-29T15:02:20.540146" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "3541" }, { "type": "SmallVariant", "id": "3567" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SLC4A4/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SLC4A4/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "1193" }, { "type": "GeneCombination", "id": "1201" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SLC4A4/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SLC4A4/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SLC4A4/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }