Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/951/genes/?format=api
{ "data": [ { "type": "Gene", "id": "BMP2", "attributes": { "go_molecular_function": [ "['growth factor activity', 'BMP receptor binding', 'SMAD binding', 'protein binding', 'co-receptor binding', 'protein serine/threonine kinase activator activity', 'phosphatase activator activity', 'signaling receptor binding', 'cytokine activity']" ], "pathway_id": [ "kegg_path:hsa04060", "kegg_path:hsa04350", "kegg_path:hsa04390", "kegg_path:hsa05200", "kegg_path:hsa05217", "kegg_path:hsa04060", "kegg_path:hsa04350", "kegg_path:hsa04390", "kegg_path:hsa05200", "kegg_path:hsa05217", "R-HSA-1474244", "R-HSA-1566948", "R-HSA-162582", "R-HSA-201451", "R-HSA-212436", "R-HSA-2129379", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878166", "R-HSA-8939902", "R-HSA-9006936" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P12643", "ensembl_id": "None", "entrez_id": "ENSG00000125845", "chromosome_number": "20", "lastmodified": "2022-08-04T14:14:59.908734" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "2185" }, { "type": "SmallVariant", "id": "2857" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/BMP2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/BMP2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "745" }, { "type": "GeneCombination", "id": "951" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/BMP2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/BMP2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/BMP2/?format=api" } }, { "type": "Gene", "id": "SMAD6", "attributes": { "go_molecular_function": [ "['chromatin binding', 'R-SMAD binding', 'co-SMAD binding', 'I-SMAD binding', 'transcription cis-regulatory region binding', 'type I activin receptor binding', 'type I transforming growth factor beta receptor binding', 'protein binding', 'metal ion binding', 'transcription regulator inhibitor activity', 'ubiquitin protein ligase binding', 'identical protein binding']" ], "pathway_id": [ "kegg_path:hsa04350", "R-HSA-162582", "R-HSA-201451", "R-HSA-212436", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878166", "R-HSA-8941326", "R-HSA-9006936" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "O43541", "ensembl_id": "None", "entrez_id": "ENSG00000137834", "chromosome_number": "15", "lastmodified": "2021-10-18T11:00:44.832989" }, "relationships": { "variant_set": { "meta": { "count": 12 }, "data": [ { "type": "SmallVariant", "id": "1210" }, { "type": "SmallVariant", "id": "2858" }, { "type": "SmallVariant", "id": "2859" }, { "type": "SmallVariant", "id": "2860" }, { "type": "SmallVariant", "id": "2861" }, { "type": "SmallVariant", "id": "2862" }, { "type": "SmallVariant", "id": "2863" }, { "type": "SmallVariant", "id": "2864" }, { "type": "SmallVariant", "id": "2865" }, { "type": "SmallVariant", "id": "2866" }, { "type": "SmallVariant", "id": "2867" }, { "type": "SmallVariant", "id": "2868" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SMAD6/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SMAD6/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "386" }, { "type": "GeneCombination", "id": "951" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SMAD6/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SMAD6/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SMAD6/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 2 } }