Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1101/genes/?format=api
{ "data": [ { "type": "Gene", "id": "HSD17B6", "attributes": { "go_molecular_function": [ "['17-beta-hydroxysteroid dehydrogenase (NADP+) activity', 'androstan-3-alpha,17-beta-diol dehydrogenase activity', '5alpha-androstane-3beta,17beta-diol dehydrogenase activity', 'testosterone 17-beta-dehydrogenase (NADP+) activity', 'testosterone dehydrogenase (NAD+) activity', '17-beta-hydroxysteroid dehydrogenase (NAD+) activity', 'NAD-retinol dehydrogenase activity', 'electron transfer activity', 'oxidoreductase activity', 'catalytic activity', 'androsterone dehydrogenase activity']" ], "pathway_id": [ "kegg_path:hsa00140", "kegg_path:hsa00830", "kegg_path:hsa01100", "kegg_path:hsa01240", "kegg_path:hsa00140", "kegg_path:hsa00830", "kegg_path:hsa01100", "kegg_path:hsa01240", "R-HSA-162582", "R-HSA-2187338", "R-HSA-2453902", "R-HSA-372790", "R-HSA-388396", "R-HSA-418594" ], "essential_gene": null, "status": "CU", "uniprot_acc": "O14756", "ensembl_id": "None", "entrez_id": "ENSG00000025423", "chromosome_number": "12", "lastmodified": "2023-05-16T12:02:33.587797" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "3207" }, { "type": "SmallVariant", "id": "3227" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HSD17B6/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HSD17B6/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "1072" }, { "type": "GeneCombination", "id": "1079" }, { "type": "GeneCombination", "id": "1098" }, { "type": "GeneCombination", "id": "1101" }, { "type": "GeneCombination", "id": "1116" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HSD17B6/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HSD17B6/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/HSD17B6/?format=api" } }, { "type": "Gene", "id": "NR5A1", "attributes": { "go_molecular_function": [ "['DNA binding', 'chromatin binding', 'zinc ion binding', 'enzyme binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'sequence-specific double-stranded DNA binding', 'nuclear receptor activity', 'protein binding', 'RNA polymerase II transcription regulatory region sequence-specific DNA binding', 'sequence-specific DNA binding', 'phospholipid binding', 'transcription coregulator binding', 'DNA-binding transcription factor activity, RNA polymerase II-specific']" ], "pathway_id": [ "kegg_path:hsa04927", "kegg_path:hsa04934", "kegg_path:hsa04927", "kegg_path:hsa04934", "R-HSA-1266738", "R-HSA-212436", "R-HSA-2990846", "R-HSA-3108232", "R-HSA-383280", "R-HSA-392499", "R-HSA-4090294", "R-HSA-452723", "R-HSA-597592", "R-HSA-73857", "R-HSA-74160", "R-HSA-9690406" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q13285", "ensembl_id": "None", "entrez_id": "ENSG00000136931", "chromosome_number": "9", "lastmodified": "2021-10-18T11:00:44.221369" }, "relationships": { "variant_set": { "meta": { "count": 19 }, "data": [ { "type": "SmallVariant", "id": "861" }, { "type": "SmallVariant", "id": "863" }, { "type": "SmallVariant", "id": "1197" }, { "type": "SmallVariant", "id": "1199" }, { "type": "SmallVariant", "id": "1206" }, { "type": "SmallVariant", "id": "1214" }, { "type": "SmallVariant", "id": "1442" }, { "type": "SmallVariant", "id": "1445" }, { "type": "SmallVariant", "id": "1697" }, { "type": "SmallVariant", "id": "2169" }, { "type": "SmallVariant", "id": "2269" }, { "type": "SmallVariant", "id": "2278" }, { "type": "SmallVariant", "id": "3160" }, { "type": "SmallVariant", "id": "3257" }, { "type": "SmallVariant", "id": "3272" }, { "type": "SmallVariant", "id": "3275" }, { "type": "SmallVariant", "id": "3411" }, { "type": "SmallVariant", "id": "3413" }, { "type": "SmallVariant", "id": "3667" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NR5A1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NR5A1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 18 }, "data": [ { "type": "GeneCombination", "id": "268" }, { "type": "GeneCombination", "id": "267" }, { "type": "GeneCombination", "id": "384" }, { "type": "GeneCombination", "id": "385" }, { "type": "GeneCombination", "id": "386" }, { "type": "GeneCombination", "id": "387" }, { "type": "GeneCombination", "id": "459" }, { "type": "GeneCombination", "id": "460" }, { "type": "GeneCombination", "id": "554" }, { "type": "GeneCombination", "id": "738" }, { "type": "GeneCombination", "id": "766" }, { "type": "GeneCombination", "id": "763" }, { "type": "GeneCombination", "id": "1055" }, { "type": "GeneCombination", "id": "1094" }, { "type": "GeneCombination", "id": "1101" }, { "type": "GeneCombination", "id": "1102" }, { "type": "GeneCombination", "id": "1144" }, { "type": "GeneCombination", "id": "1235" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NR5A1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NR5A1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NR5A1/?format=api" } }, { "type": "Gene", "id": "PROK2", "attributes": { "go_molecular_function": [ "['G protein-coupled receptor binding', 'protein binding']" ], "pathway_id": [ "R-HSA-162582", "R-HSA-372790", "R-HSA-373076", "R-HSA-375276", "R-HSA-388396", "R-HSA-416476", "R-HSA-500792" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q9HC23", "ensembl_id": "None", "entrez_id": "ENSG00000163421", "chromosome_number": "3", "lastmodified": "2021-10-18T11:00:44.418504" }, "relationships": { "variant_set": { "meta": { "count": 8 }, "data": [ { "type": "SmallVariant", "id": "392" }, { "type": "SmallVariant", "id": "556" }, { "type": "SmallVariant", "id": "856" }, { "type": "SmallVariant", "id": "1827" }, { "type": "SmallVariant", "id": "2726" }, { "type": "SmallVariant", "id": "2974" }, { "type": "SmallVariant", "id": "3273" }, { "type": "SmallVariant", "id": "3471" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PROK2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PROK2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 7 }, "data": [ { "type": "GeneCombination", "id": "133" }, { "type": "GeneCombination", "id": "190" }, { "type": "GeneCombination", "id": "265" }, { "type": "GeneCombination", "id": "906" }, { "type": "GeneCombination", "id": "991" }, { "type": "GeneCombination", "id": "1101" }, { "type": "GeneCombination", "id": "1165" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PROK2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PROK2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PROK2/?format=api" } }, { "type": "Gene", "id": "SEMA3F", "attributes": { "go_molecular_function": [ "['semaphorin receptor binding', 'chemorepellent activity']" ], "pathway_id": [ "kegg_path:hsa04360" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q13275", "ensembl_id": "None", "entrez_id": "ENSG00000001617", "chromosome_number": "3", "lastmodified": "2023-05-16T12:02:33.650943" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3274" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SEMA3F/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SEMA3F/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "1101" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SEMA3F/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SEMA3F/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SEMA3F/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }