Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/412/genes/?format=api
{ "data": [ { "type": "Gene", "id": "CUL4B", "attributes": { "go_molecular_function": [ "ubiquitin protein ligase binding", "protein binding", "ubiquitin-protein transferase activity" ], "pathway_id": [ "R-HSA-6781827", "kegg_path:hsa04120", "R-HSA-392499", "R-HSA-5696394", "R-HSA-5696395", "R-HSA-73894", "R-HSA-110314", "R-HSA-5696398", "R-HSA-6782135", "R-HSA-73893", "kegg_path:hsa05170", "kegg_path:hsa03420", "R-HSA-5696399", "R-HSA-5696400", "R-HSA-6781823", "R-HSA-6782210", "R-HSA-8951664", "R-HSA-597592" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q13620", "ensembl_id": "ENSG00000158290", "entrez_id": "8450", "chromosome_number": "X", "lastmodified": "2021-10-18T11:00:44.369695" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1317" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CUL4B/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CUL4B/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "412" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CUL4B/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CUL4B/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CUL4B/?format=api" } }, { "type": "Gene", "id": "DAPK1", "attributes": { "go_molecular_function": [ "protein binding", "transferase activity", "kinase activity", "ATP binding", "protein serine/threonine kinase activity", "nucleotide binding", "protein kinase activity", "GTP binding", "protein serine kinase activity", "calmodulin binding" ], "pathway_id": [ "R-HSA-5357769", "kegg_path:hsa05200", "kegg_path:hsa05219", "kegg_path:hsa04140", "R-HSA-109581", "R-HSA-418889", "R-HSA-5357801" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P53355", "ensembl_id": "ENSG00000196730", "entrez_id": "1612", "chromosome_number": "9", "lastmodified": "2021-10-18T11:00:45.007174" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1318" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/DAPK1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/DAPK1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "412" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/DAPK1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/DAPK1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/DAPK1/?format=api" } }, { "type": "Gene", "id": "EMX2", "attributes": { "go_molecular_function": [ "protein binding", "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "sequence-specific double-stranded DNA binding", "DNA-binding transcription factor activity, RNA polymerase II-specific", "DNA binding" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q04743", "ensembl_id": "ENSG00000170370", "entrez_id": "2018", "chromosome_number": "10", "lastmodified": "2021-10-18T11:00:44.502125" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1319" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/EMX2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/EMX2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "412" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/EMX2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/EMX2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/EMX2/?format=api" } }, { "type": "Gene", "id": "FREM2", "attributes": { "go_molecular_function": [ "metal ion binding", "protein binding" ], "pathway_id": [ "kegg_path:hsa04512" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q5SZK8", "ensembl_id": "ENSG00000150893", "entrez_id": "341640", "chromosome_number": "13", "lastmodified": "2021-10-18T11:00:44.512222" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "715" }, { "type": "SmallVariant", "id": "749" }, { "type": "SmallVariant", "id": "1320" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FREM2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FREM2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "230" }, { "type": "GeneCombination", "id": "238" }, { "type": "GeneCombination", "id": "412" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FREM2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FREM2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FREM2/?format=api" } }, { "type": "Gene", "id": "IGFBP2", "attributes": { "go_molecular_function": [ "growth factor binding", "insulin-like growth factor binding", "protein binding", "insulin-like growth factor I binding", "insulin-like growth factor II binding" ], "pathway_id": [ "R-HSA-381426", "R-HSA-392499" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P18065", "ensembl_id": "ENSG00000115457", "entrez_id": "3485", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.496282" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1321" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/IGFBP2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/IGFBP2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "412" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/IGFBP2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/IGFBP2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/IGFBP2/?format=api" } }, { "type": "Gene", "id": "MAML2", "attributes": { "go_molecular_function": [ "transcription coactivator activity" ], "pathway_id": [ "kegg_path:hsa04658", "R-HSA-2197563", "kegg_path:hsa05165", "R-HSA-1266738", "R-HSA-212436", "R-HSA-9013694", "R-HSA-2122947", "R-HSA-9013695", "R-HSA-1980145", "R-HSA-350054", "R-HSA-5663202", "R-HSA-74160", "R-HSA-9013508", "kegg_path:hsa04330", "R-HSA-8878159", "R-HSA-162582", "R-HSA-1980143", "R-HSA-1912408", "R-HSA-210744", "R-HSA-2644603", "R-HSA-2894858", "R-HSA-186712", "R-HSA-73857", "R-HSA-157118", "R-HSA-1912422", "R-HSA-2894862", "R-HSA-9012852", "R-HSA-8941856", "R-HSA-1643685", "R-HSA-2644602", "R-HSA-2644606" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q8IZL2", "ensembl_id": "ENSG00000184384", "entrez_id": "84441", "chromosome_number": "11", "lastmodified": "2021-10-18T11:00:44.549023" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "760" }, { "type": "SmallVariant", "id": "1292" }, { "type": "SmallVariant", "id": "1322" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAML2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAML2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "240" }, { "type": "GeneCombination", "id": "409" }, { "type": "GeneCombination", "id": "412" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAML2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAML2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MAML2/?format=api" } }, { "type": "Gene", "id": "MAML3", "attributes": { "go_molecular_function": [ "transcription coactivator activity" ], "pathway_id": [ "R-HSA-157118", "R-HSA-186712", "R-HSA-73857", "R-HSA-2644603", "R-HSA-2894858", "R-HSA-1912422", "R-HSA-2894862", "R-HSA-9012852", "R-HSA-2644602", "R-HSA-1643685", "R-HSA-8941856", "R-HSA-210744", "R-HSA-2644606", "R-HSA-1266738", "kegg_path:hsa05165", "kegg_path:hsa04658", "R-HSA-2197563", "R-HSA-1980145", "R-HSA-2122947", "R-HSA-9013695", "R-HSA-212436", "R-HSA-9013694", "R-HSA-9013508", "R-HSA-350054", "R-HSA-5663202", "R-HSA-74160", "R-HSA-1912408", "R-HSA-162582", "R-HSA-1980143", "kegg_path:hsa04330", "R-HSA-8878159" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q96JK9", "ensembl_id": "ENSG00000196782", "entrez_id": "55534", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:44.620397" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "730" }, { "type": "SmallVariant", "id": "755" }, { "type": "SmallVariant", "id": "1305" }, { "type": "SmallVariant", "id": "1312" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAML3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAML3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "234" }, { "type": "GeneCombination", "id": "239" }, { "type": "GeneCombination", "id": "410" }, { "type": "GeneCombination", "id": "411" }, { "type": "GeneCombination", "id": "412" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAML3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAML3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MAML3/?format=api" } }, { "type": "Gene", "id": "MAMLD1", "attributes": { "go_molecular_function": [ "['molecular_function']" ], "pathway_id": [ "R-HSA-1266738", "R-HSA-157118", "R-HSA-162582", "R-HSA-1643685", "R-HSA-186712", "R-HSA-1912408", "R-HSA-1912422", "R-HSA-1980143", "R-HSA-1980145", "R-HSA-210744", "R-HSA-2122947", "R-HSA-212436", "R-HSA-2197563", "R-HSA-2644602", "R-HSA-2644603", "R-HSA-2644606", "R-HSA-2894858", "R-HSA-2894862", "R-HSA-350054", "R-HSA-5663202", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878159", "R-HSA-8941856", "R-HSA-9012852", "R-HSA-9013508", "R-HSA-9013694", "R-HSA-9013695", "R-HSA-1266738", "R-HSA-157118", "R-HSA-162582", "R-HSA-1643685", "R-HSA-186712", "R-HSA-1912408", "R-HSA-1912422", "R-HSA-1980143", "R-HSA-1980145", "R-HSA-210744", "R-HSA-2122947", "R-HSA-212436", "R-HSA-2197563", "R-HSA-2644602", "R-HSA-2644603", "R-HSA-2644606", "R-HSA-2894858", "R-HSA-2894862", "R-HSA-350054", "R-HSA-5663202", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878159", "R-HSA-8941856", "R-HSA-9012852", "R-HSA-9013508", "R-HSA-9013694", "R-HSA-9013695" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q13495", "ensembl_id": "None", "entrez_id": "ENSG00000013619", "chromosome_number": "X", "lastmodified": "2021-10-18T11:00:44.997839" }, "relationships": { "variant_set": { "meta": { "count": 22 }, "data": [ { "type": "SmallVariant", "id": "581" }, { "type": "SmallVariant", "id": "717" }, { "type": "SmallVariant", "id": "722" }, { "type": "SmallVariant", "id": "729" }, { "type": "SmallVariant", "id": "733" }, { "type": "SmallVariant", "id": "736" }, { "type": "SmallVariant", "id": "742" }, { "type": "SmallVariant", "id": "745" }, { "type": "SmallVariant", "id": "752" }, { "type": "SmallVariant", "id": "757" }, { "type": "SmallVariant", "id": "1268" }, { "type": "SmallVariant", "id": "1278" }, { "type": "SmallVariant", "id": "1280" }, { "type": "SmallVariant", "id": "1283" }, { "type": "SmallVariant", "id": "1294" }, { "type": "SmallVariant", "id": "1310" }, { "type": "SmallVariant", "id": "1316" }, { "type": "SmallVariant", "id": "3192" }, { "type": "SmallVariant", "id": "3200" }, { "type": "SmallVariant", "id": "3252" }, { "type": "SmallVariant", "id": "3259" }, { "type": "SmallVariant", "id": "3325" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAMLD1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAMLD1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 26 }, "data": [ { "type": "GeneCombination", "id": "236" }, { "type": "GeneCombination", "id": "240" }, { "type": "GeneCombination", "id": "200" }, { "type": "GeneCombination", "id": "237" }, { "type": "GeneCombination", "id": "238" }, { "type": "GeneCombination", "id": "231" }, { "type": "GeneCombination", "id": "232" }, { "type": "GeneCombination", "id": "233" }, { "type": "GeneCombination", "id": "234" }, { "type": "GeneCombination", "id": "235" }, { "type": "GeneCombination", "id": "239" }, { "type": "GeneCombination", "id": "406" }, { "type": "GeneCombination", "id": "407" }, { "type": "GeneCombination", "id": "408" }, { "type": "GeneCombination", "id": "405" }, { "type": "GeneCombination", "id": "409" }, { "type": "GeneCombination", "id": "410" }, { "type": "GeneCombination", "id": "411" }, { "type": "GeneCombination", "id": "412" }, { "type": "GeneCombination", "id": "1067" }, { "type": "GeneCombination", "id": "1068" }, { "type": "GeneCombination", "id": "1091" }, { "type": "GeneCombination", "id": "1092" }, { "type": "GeneCombination", "id": "1095" }, { "type": "GeneCombination", "id": "1120" }, { "type": "GeneCombination", "id": "1122" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAMLD1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAMLD1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MAMLD1/?format=api" } }, { "type": "Gene", "id": "MYO7A", "attributes": { "go_molecular_function": [ "['calmodulin binding', 'spectrin binding', 'protein binding', 'protein domain specific binding', 'microfilament motor activity', 'actin filament binding', 'ATP binding']" ], "pathway_id": [ "R-HSA-162582", "R-HSA-2187338", "R-HSA-2453902", "R-HSA-372790", "R-HSA-388396", "R-HSA-418594", "R-HSA-162582", "R-HSA-2187338", "R-HSA-2453902", "R-HSA-372790", "R-HSA-388396", "R-HSA-418594" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q13402", "ensembl_id": "None", "entrez_id": "ENSG00000137474", "chromosome_number": "11", "lastmodified": "2021-10-18T11:00:44.573189" }, "relationships": { "variant_set": { "meta": { "count": 28 }, "data": [ { "type": "SmallVariant", "id": "509" }, { "type": "SmallVariant", "id": "206" }, { "type": "SmallVariant", "id": "207" }, { "type": "SmallVariant", "id": "211" }, { "type": "SmallVariant", "id": "213" }, { "type": "SmallVariant", "id": "218" }, { "type": "SmallVariant", "id": "221" }, { "type": "SmallVariant", "id": "503" }, { "type": "SmallVariant", "id": "507" }, { "type": "SmallVariant", "id": "720" }, { "type": "SmallVariant", "id": "727" }, { "type": "SmallVariant", "id": "728" }, { "type": "SmallVariant", "id": "737" }, { "type": "SmallVariant", "id": "747" }, { "type": "SmallVariant", "id": "748" }, { "type": "SmallVariant", "id": "759" }, { "type": "SmallVariant", "id": "1323" }, { "type": "SmallVariant", "id": "1324" }, { "type": "SmallVariant", "id": "1975" }, { "type": "SmallVariant", "id": "2233" }, { "type": "SmallVariant", "id": "2235" }, { "type": "SmallVariant", "id": "2237" }, { "type": "SmallVariant", "id": "2239" }, { "type": "SmallVariant", "id": "2241" }, { "type": "SmallVariant", "id": "2243" }, { "type": "SmallVariant", "id": "2245" }, { "type": "SmallVariant", "id": "3704" }, { "type": "SmallVariant", "id": "3712" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MYO7A/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MYO7A/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 16 }, "data": [ { "type": "GeneCombination", "id": "75" }, { "type": "GeneCombination", "id": "76" }, { "type": "GeneCombination", "id": "77" }, { "type": "GeneCombination", "id": "78" }, { "type": "GeneCombination", "id": "80" }, { "type": "GeneCombination", "id": "236" }, { "type": "GeneCombination", "id": "240" }, { "type": "GeneCombination", "id": "168" }, { "type": "GeneCombination", "id": "238" }, { "type": "GeneCombination", "id": "231" }, { "type": "GeneCombination", "id": "233" }, { "type": "GeneCombination", "id": "412" }, { "type": "GeneCombination", "id": "758" }, { "type": "GeneCombination", "id": "757" }, { "type": "GeneCombination", "id": "1256" }, { "type": "GeneCombination", "id": "1253" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MYO7A/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MYO7A/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MYO7A/?format=api" } }, { "type": "Gene", "id": "NOTCH1", "attributes": { "go_molecular_function": [ "enzyme inhibitor activity", "calcium ion binding", "Notch binding", "chromatin DNA binding", "protein binding", "transcription coactivator activity", "transmembrane signaling receptor activity", "enzyme binding", "identical protein binding" ], "pathway_id": [ "R-HSA-2644603", "R-HSA-2894858", "R-HSA-157118", "R-HSA-1912420", "R-HSA-2660825", "R-HSA-5083630", "R-HSA-2660826", "R-HSA-1912422", "R-HSA-1643685", "kegg_path:hsa04919", "R-HSA-5668914", "kegg_path:hsa04658", "R-HSA-1266738", "R-HSA-2644607", "kegg_path:hsa05165", "R-HSA-3906995", "kegg_path:hsa01522", "R-HSA-2122947", "R-HSA-9013695", 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