Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1106/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ATP7B", "attributes": { "go_molecular_function": [ "['P-type monovalent copper transporter activity', 'copper ion transmembrane transporter activity', 'P-type divalent copper transporter activity', 'ATP binding', 'copper ion binding', 'protein binding']" ], "pathway_id": [ "kegg_path:hsa01524", "kegg_path:hsa04978", "kegg_path:hsa01524", "kegg_path:hsa04978", "kegg_path:hsa01524", "kegg_path:hsa04978", "R-HSA-382551", "R-HSA-936837", "R-HSA-983712" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P35670", "ensembl_id": "None", "entrez_id": "ENSG00000123191", "chromosome_number": "13", "lastmodified": "2023-05-16T12:02:32.481279" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "2636" }, { "type": "SmallVariant", "id": "3119" }, { "type": "SmallVariant", "id": "3285" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ATP7B/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ATP7B/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "879" }, { "type": "GeneCombination", "id": "1044" }, { "type": "GeneCombination", "id": "1106" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ATP7B/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ATP7B/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ATP7B/?format=api" } }, { "type": "Gene", "id": "COL1A1", "attributes": { "go_molecular_function": [ "['extracellular matrix structural constituent conferring tensile strength', 'extracellular matrix structural constituent', 'protease binding', 'protein binding', 'metal ion binding', 'platelet-derived growth factor binding', 'identical protein binding']" ], "pathway_id": [ "kegg_path:hsa04151", "kegg_path:hsa04510", "kegg_path:hsa04512", "kegg_path:hsa04611", "kegg_path:hsa04926", "kegg_path:hsa04933", "kegg_path:hsa04974", "kegg_path:hsa05146", "kegg_path:hsa05165", "kegg_path:hsa05205", "R-HSA-109582", "R-HSA-114604", "R-HSA-1280218", "R-HSA-1442490", "R-HSA-1474228", "R-HSA-1474244", "R-HSA-1474290", "R-HSA-162582", "R-HSA-1650814", "R-HSA-168256", "R-HSA-198933", "R-HSA-2022090", "R-HSA-202733", "R-HSA-212436", "R-HSA-216083", "R-HSA-2173782", "R-HSA-2214320", "R-HSA-2243919", "R-HSA-3000170", "R-HSA-3000171", "R-HSA-3000178", "R-HSA-3000480", "R-HSA-430116", "R-HSA-5653656", "R-HSA-6806834", "R-HSA-73857", "R-HSA-74160", "R-HSA-75892", "R-HSA-76002", "R-HSA-76009", "R-HSA-8874081", "R-HSA-8875878", "R-HSA-8878166", "R-HSA-8940973", "R-HSA-8941326", "R-HSA-8948216", "R-HSA-9006934" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P02452", "ensembl_id": "None", "entrez_id": "ENSG00000108821", "chromosome_number": "17", "lastmodified": "2023-05-16T12:02:33.659035" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3284" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/COL1A1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/COL1A1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "1106" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/COL1A1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/COL1A1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/COL1A1/?format=api" } }, { "type": "Gene", "id": "GPC3", "attributes": { "go_molecular_function": [ "['peptidyl-dipeptidase inhibitor activity', 'protein binding']" ], "pathway_id": [ "kegg_path:hsa05205", "kegg_path:hsa05205", "R-HSA-1430728", "R-HSA-162582", "R-HSA-1630316", "R-HSA-1638091", "R-HSA-1643685", "R-HSA-1793185", "R-HSA-196854", "R-HSA-1971475", "R-HSA-2022928", "R-HSA-2024096", "R-HSA-2187338", "R-HSA-3560782", "R-HSA-3560783", "R-HSA-3560801", "R-HSA-3656237", "R-HSA-3656253", "R-HSA-372790", "R-HSA-3781865", "R-HSA-381426", "R-HSA-388396", "R-HSA-392499", "R-HSA-418594", "R-HSA-4420332", "R-HSA-5668914", "R-HSA-597592", "R-HSA-6806667", "R-HSA-71387", "R-HSA-8957275", "R-HSA-975634", "kegg_path:hsa05205" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P51654", "ensembl_id": "None", "entrez_id": "ENSG00000147257", "chromosome_number": "X", "lastmodified": "2023-05-16T12:02:33.662985" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "3286" }, { "type": "SmallVariant", "id": "3334" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GPC3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GPC3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "1106" }, { "type": "GeneCombination", "id": "1125" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GPC3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GPC3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GPC3/?format=api" } }, { "type": "Gene", "id": "HSD17B3", "attributes": { "go_molecular_function": [ "['17-beta-hydroxysteroid dehydrogenase (NADP+) activity', 'oxidoreductase activity', 'testosterone dehydrogenase [NAD(P)] activity', 'testosterone 17-beta-dehydrogenase (NADP+) activity']" ], "pathway_id": [ "kegg_path:hsa00140", "kegg_path:hsa01100", "R-HSA-1430728", "R-HSA-193048", "R-HSA-196071", "R-HSA-556833", "R-HSA-75105", "R-HSA-75876", "R-HSA-8957322", "R-HSA-8978868", "kegg_path:hsa00140", "kegg_path:hsa01100" ], "essential_gene": null, "status": "CU", "uniprot_acc": "P37058", "ensembl_id": "None", "entrez_id": "ENSG00000130948", "chromosome_number": "9", "lastmodified": "2023-05-16T12:02:33.563033" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "3185" }, { "type": "SmallVariant", "id": "3215" }, { "type": "SmallVariant", "id": "3237" }, { "type": "SmallVariant", "id": "3283" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HSD17B3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HSD17B3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "1064" }, { "type": "GeneCombination", "id": "1066" }, { "type": "GeneCombination", "id": "1075" }, { "type": "GeneCombination", "id": "1085" }, { "type": "GeneCombination", "id": "1106" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HSD17B3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HSD17B3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/HSD17B3/?format=api" } }, { "type": "Gene", "id": "RXFP2", "attributes": { "go_molecular_function": [ "['G protein-coupled peptide receptor activity', 'protein-hormone receptor activity']" ], "pathway_id": [ "kegg_path:hsa04080", "kegg_path:hsa04926", "R-HSA-162582", "R-HSA-1643685", "R-HSA-372790", "R-HSA-373076", "R-HSA-375276", "R-HSA-388396", "R-HSA-418555", "R-HSA-444821", "R-HSA-500792", "R-HSA-5663205", "R-HSA-9658195", "R-HSA-9660821", "R-HSA-9662851", "R-HSA-9664433" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q8WXD0", "ensembl_id": "None", "entrez_id": "ENSG00000133105", "chromosome_number": "13", "lastmodified": "2023-05-16T12:02:33.575225" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "3193" }, { "type": "SmallVariant", "id": "3251" }, { "type": "SmallVariant", "id": "3287" }, { "type": "SmallVariant", "id": "3319" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RXFP2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RXFP2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "1067" }, { "type": "GeneCombination", "id": "1091" }, { "type": "GeneCombination", "id": "1092" }, { "type": "GeneCombination", "id": "1106" }, { "type": "GeneCombination", "id": "1116" }, { "type": "GeneCombination", "id": "1122" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RXFP2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RXFP2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/RXFP2/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 5 } }