Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/506/genes/?format=api
{ "data": [ { "type": "Gene", "id": "GRHL1", "attributes": { "go_molecular_function": [ "['protein homodimerization activity', 'chromatin DNA binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'sequence-specific double-stranded DNA binding', 'sequence-specific DNA binding', 'protein binding', 'transcription cis-regulatory region binding', 'DNA-binding transcription activator activity, RNA polymerase II-specific', 'DNA-binding transcription factor activity, RNA polymerase II-specific']" ], "pathway_id": [ "R-HSA-1430728", "R-HSA-1989781", "R-HSA-400206", "R-HSA-556833" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q9NZI5", "ensembl_id": "None", "entrez_id": "ENSG00000134317", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.542708" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1574" }, { "type": "SmallVariant", "id": "3566" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GRHL1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GRHL1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "506" }, { "type": "GeneCombination", "id": "1201" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GRHL1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GRHL1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GRHL1/?format=api" } }, { "type": "Gene", "id": "MTHFS", "attributes": { "go_molecular_function": [ "5-formyltetrahydrofolate cyclo-ligase activity", "ATP binding", "nucleotide binding", "ligase activity", "folic acid binding", "metal ion binding" ], "pathway_id": [ "kegg_path:hsa01100", "R-HSA-1430728", "R-HSA-196757", "kegg_path:hsa00670", "R-HSA-196849", "R-HSA-196854" ], "essential_gene": null, "status": "CU", "uniprot_acc": "P49914", "ensembl_id": "ENSG00000136371", "entrez_id": "10588", "chromosome_number": "15", "lastmodified": "2021-10-18T11:00:44.708325" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1573" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MTHFS/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MTHFS/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "506" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MTHFS/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MTHFS/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MTHFS/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 2 } }